State University of New York System

About: State University of New York System is a education organization based out in Albany, New York, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 54077 authors who have published 78070 publications receiving 2985160 citations.

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG.

Abstract: Oxidative damage to DNA, reflected in the formation of 8-oxo-7-hydrodeoxyguanosine (8-oxodG), may be important in mutagenesis, carcinogenesis and the ageing process. Kuchino et al. studied DNA synthesis on oligodeoxynucleotide templates containing 8-oxodG, concluding that the modified base lacked base pairing specificity and directed misreading of pyrimidine residues neighbouring the lesion. Here we report different results, using an approach in which the several products of a DNA polymerase reaction can be measured. In contrast to the earlier report, we find that dCMP and dAMP are incorporated selectively opposite 8-oxodG with transient inhibition of chain extension occurring 3' to the modified base. The potentially mutagenic insertion of dAMP is targeted exclusively to the site of the lesion. The ratio of dCMP to dAMP incorporated varies, depending on the DNA polymerase involved. Chain extension from the dA.8-oxodG pair was efficiently catalysed by all polymerases tested.

Some Exact Results for the Many-Body Problem in one Dimension with Repulsive Delta-Function Interaction

Abstract: The repulsive $\ensuremath{\delta}$ interaction problem in one dimension for $N$ particles is reduced, through the use of Bethe's hypothesis, to an eigenvalue problem of matrices of the same sizes as the irreducible representations $R$ of the permutation group ${S}_{N}$. For some $R'\mathrm{s}$ this eigenvalue problem itself is solved by a second use of Bethe's hypothesis, in a generalized form. In particular, the ground-state problem of spin-\textonehalf{} fermions is reduced to a generalized Fredholm equation.

Biogeochemical Hot Spots and Hot Moments at the Interface of Terrestrial and Aquatic Ecosystems

Abstract: Rates and reactions of biogeochemical processes vary in space and time to produce both hot spots and hot moments of elemental cycling. We define biogeochemical hot spots as patches that show disproportionately high reaction rates relative to the surrounding matrix, whereas hot moments are defined as short periods of time that exhibit disproportionately high reaction rates relative to longer intervening time periods. As has been appreciated by ecologists for decades, hot spot and hot moment activity is often enhanced at terrestrial-aquatic interfaces. Using examples from the carbon (C) and nitrogen (N) cycles, we show that hot spots occur where hydrological flowpaths converge with substrates or other flowpaths containing complementary or missing reactants. Hot moments occur when episodic hydrological flowpaths reactivate and/or mobilize accumulated reactants. By focusing on the delivery of specific missing reactants via hydrologic flowpaths, we can forge a better mechanistic understanding of the factors that create hot spots and hot moments. Such a mechanistic understanding is necessary so that biogeochemical hot spots can be identified at broader spatiotemporal scales and factored into quantitative models. We specifically recommend that resource managers incorporate both natural and artificially created biogeochemical hot spots into their plans for water quality management. Finally, we emphasize the needs for further research to assess the potential importance of hot spot and hot moment phenomena in the cycling of different bioactive elements, improve our ability to predict their occurrence, assess their importance in landscape biogeochemistry, and evaluate their utility as tools for resource management.

A database for handwritten text recognition research

Abstract: An image database for handwritten text recognition research is described. Digital images of approximately 5000 city names, 5000 state names, 10000 ZIP Codes, and 50000 alphanumeric characters are included. Each image was scanned from mail in a working post office at 300 pixels/in in 8-bit gray scale on a high-quality flat bed digitizer. The data were unconstrained for the writer, style, and method of preparation. These characteristics help overcome the limitations of earlier databases that contained only isolated characters or were prepared in a laboratory setting under prescribed circumstances. Also, the database is divided into explicit training and testing sets to facilitate the sharing of results among researchers as well as performance comparisons. >