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Institution

State University of New York System

EducationAlbany, New York, United States
About: State University of New York System is a education organization based out in Albany, New York, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 54077 authors who have published 78070 publications receiving 2985160 citations.
Topics: Population, Poison control, RNA, Gene, Receptor


Papers
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Journal ArticleDOI
TL;DR: A method that combines region growing and edge detection for image segmentation is presented and is thought that the success in the tool images is because the objects shown occupy areas of many pixels, making it is easy to select parameters to separate signal information from noise.
Abstract: A method that combines region growing and edge detection for image segmentation is presented. The authors start with a split-and merge algorithm wherein the parameters have been set up so that an over-segmented image results. Region boundaries are then eliminated or modified on the basis of criteria that integrate contrast with boundary smoothness, variation of the image gradient along the boundary, and a criterion that penalizes for the presence of artifacts reflecting the data structure used during segmentation (quadtree in this case). The algorithms were implemented in the C language on a Sun 3/160 workstation running under the Unix operating system. Simple tool images and aerial photographs were used to test the algorithms. The impression of human observers is that the method is very successful on the tool images and less so on the aerial photograph images. It is thought that the success in the tool images is because the objects shown occupy areas of many pixels, making it is easy to select parameters to separate signal information from noise. >

567 citations

Journal ArticleDOI
TL;DR: Fundamental differences in the mechanisms of receptor anchoring at postsynaptic sites are indicated, both regarding the anchoring of a single receptor in pyramidal cells versus GABAergic interneurons and regarding the Anchoring of different receptors (AMPA vs NMDA receptors) at a single class of post Synaptic sites on Pyramidal cell dendritic spines.
Abstract: We used actin-perturbing agents and detergent extraction of primary hippocampal cultures to test directly the role of the actin cytoskeleton in localizing GABAA receptors, AMPA- and NMDA-type glutamate receptors, and potential anchoring proteins at postsynaptic sites. Excitatory postsynaptic sites on dendritic spines contained a high concentration of F-actin that was resistant to cytochalasin D but could be depolymerized using the novel compound latrunculin A. Depolymerization of F-actin led to a 40% decrease in both the number of synaptic NMDA receptor (NMDAR1) clusters and the number of AMPA receptor (GluR1)-labeled spines. The nonsynaptic NMDA receptors appeared to remain clustered and to coalesce in cell bodies. α-Actinin-2, which binds both actin and NMDA receptors, dissociated from the receptor clusters, but PSD-95 remained associated with both the synaptic and nonsynaptic receptor clusters, consistent with a proposed cross-linking function. AMPA receptors behaved differently; on GABAergic neurons, the clusters redistributed to nonsynaptic sites, whereas on pyramidal neurons, many of the clusters appeared to disperse. Furthermore, in control neurons, AMPA receptors were detergent extractable from pyramidal cell spines, whereas AMPA receptors on GABAergic neurons and NMDA receptors were unextractable. GABAA receptors were not dependent on F-actin for the maintenance or synaptic localization of clusters. These results indicate fundamental differences in the mechanisms of receptor anchoring at postsynaptic sites, both regarding the anchoring of a single receptor (the AMPA receptor) in pyramidal cells versus GABAergic interneurons and regarding the anchoring of different receptors (AMPA vs NMDA receptors) at a single class of postsynaptic sites on pyramidal cell dendritic spines.

566 citations

Journal ArticleDOI
TL;DR: In this article, an analysis of wetland mosaics was performed for two regions of the northeastern United States to assess the degree to which historical wetland loss alters the metrics of wet land mosaics and to assess potential future effects mediated by differently structured wetland regulations.
Abstract: Most species of wetland-dependent organisms live in multiple local populations sustained through occasional migration. Retention of minimum wetland densities in human-dominated landscapes is fundamental to conserving these organisms. An analysis of wetland mosaics was performed for two regions of the northeastern United States to assess the degree to which historical wetland loss alters the metrics of wetland mosaics and to assess potential future effects mediated by differently structured wetland regulations. These analyses indicated that profound reductions in wetland density and proximity are associated with increased human populations and that protections for all wetlands >1 acre (0.4 ha) are likely required to retain wetland densities minimally sufficient to sustain the wetland biota.

565 citations

Journal ArticleDOI
TL;DR: The current status is summarized of investigations of the Martian atmosphere, in which use was made of the mass spectrometers that function as the analytical component of the molecular analysis experiments on the two Viking landers.
Abstract: The current status is summarized of investigations of the composition of the Martian atmosphere, in which use was made of the mass spectrometers that function as the analytical component of the molecular analysis experiments on the two Viking landers. The following points seem well established: N2, Ar-40, Ne, Kr, Xe, and the primordial isotope of Ar are present. The present atmosphere of Mars represents only a small fraction of the total amount of volatiles outgassed by the planet, so that high surface pressure and abundant water may have been present. The noble gases in the Martian atmosphere exhibit a relative abundance pattern similar to that in the earth's atmosphere and (except for Xe) to that in the primordial component of meteorites. The existence of a 'planetary component' is thus proven, supporting the arguments of those who favor a fractionation of noble gases prior to the formation of the planets. In spite of these similarities, the isotopic ratios of nitrogen, argon, and xenon indicate that the histories of the Martian and the earth's atmospheres have been very different.

565 citations

Journal ArticleDOI
TL;DR: The absorption strength of the stretching modes does not depend on the details of sample preparation, contrary to hypotheses previously invoked to explain experimental data, and previously published data for both the wagging and stretching modes are consistent with the proportionality factors determined.
Abstract: We have used infrared transmission and nuclear-reaction analysis to determine the ir absorption strength of the Si-H wagging and stretching modes in hydrogenated amorphous silicon (a-Si:H). The films were deposited by plasma-assisted chemical vapor deposition and reactive magnetron sputtering. We show that the widely used ir-data-analysis method of Brodsky, Cardona, and Cuomo can lead to significant errors in determining the absorption coefficients, particularly for films less than \ensuremath{\sim}1 \ensuremath{\mu}m thick. To eliminate these errors we explicitly take into account the effects of optical interference to analyze our data. We show that the hydrogen content can be determined from the stretching modes at \ensuremath{\omega}=2000 and 2100 ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$ as well as the wagging mode at \ensuremath{\omega}=640 ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$. By assigning different oscillator strengths to the 2000- and 2100-${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$ modes, we show that the absorption strength of the stretching modes does not depend on the details of sample preparation, contrary to hypotheses previously invoked to explain experimental data. We obtain ${\mathit{A}}_{640}$=(2.1\ifmmode\pm\else\textpm\fi{}0.2)\ifmmode\times\else\texttimes\fi{}${10}^{19}$ ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}2}$, ${\mathit{A}}_{2000}$=(9.0\ifmmode\pm\else\textpm\fi{}1.0)\ifmmode\times\else\texttimes\fi{}${10}^{19}$ ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}2}$, and ${\mathit{A}}_{2100}$=(2.2\ifmmode\pm\else\textpm\fi{}0.2)\ifmmode\times\else\texttimes\fi{}${10}^{20}$ ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}2}$ for the proportionality constants between the hydrogen concentration and the integrated absorbance of the wagging and stretching modes. The value of ${\mathit{A}}_{640}$ is \ensuremath{\sim}30% larger than the generally used value. We show that previously published data for both the wagging and stretching modes are consistent with the proportionality factors determined in the present study.

564 citations


Authors

Showing all 54162 results

NameH-indexPapersCitations
Meir J. Stampfer2771414283776
Bert Vogelstein247757332094
Zhong Lin Wang2452529259003
Peter Libby211932182724
Robert M. Califf1961561167961
Stephen V. Faraone1881427140298
David L. Kaplan1771944146082
David Baker1731226109377
Nora D. Volkow165958107463
David R. Holmes1611624114187
Richard J. Davidson15660291414
Ronald G. Crystal15599086680
Jovan Milosevic1521433106802
James J. Collins15166989476
Mark A. Rubin14569995640
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202325
2022168
20212,825
20202,891
20192,528
20182,456