Stevens Institute of Technology

About: Stevens Institute of Technology is a education organization based out in Hoboken, New Jersey, United States. It is known for research contribution in the topics: Cognitive radio & Wireless network. The organization has 5440 authors who have published 12684 publications receiving 296875 citations. The organization is also known as: Stevens & Stevens Tech.

Executive Job Demands: New Insights for Explaining Strategic Decisions and Leader Behaviors

Abstract: Executive jobs vary widely in the difficulty they pose for their incumbents, yet research on top executives and strategic decision making has largely ignored this reality. We build on work in industrial/organizational psychology to develop the construct of executive job demands; discuss its major determinants; propose some of its key implications for strategic choices and leadership behaviors; and propose the usefulness of this construct in advancing research on numerous fronts, including agency theory, executive compensation, and upper echelons.

Enablers and inhibitors of business-IT alignment

Abstract: This paper provides insight into identifying areas that help or hinder business-IT alignment. Alignment focuses on the activities that management performs to achieve cohesive goals across the organization. The aim of this paper is to determine the most important enablers and inhibitors to alignment. The paper presents and analyzes the results of a multi-year study of strategic alignment. Data were obtained from business and information technology executives from over 500 firms representing 15 industries who attended classes addressing alignment at IBM’s Advanced Business Institute. The executives were asked to describe those activities that assist in achieving alignment and those which seem to hinder it. These enablers and inhibitors to alignment were then analyzed with respect to industry, to time, and executive position. The results indicate that certain activities can assist in the achievement of this state of alignment while others are clearly barriers. Achieving alignment is evolutionary and dynamic. It requires strong support from senior management, good working relationships, strong leadership, appropriate prioritization, trust, and effective communication, as well as a thorough understanding of the

Ab initio relativistic effective potentials with spin–orbit operators. IV. Cs through Rn

Abstract: A refined version of the ‘‘shape consistent’’ effective potential procedure of Christiansen, Lee, and Pitzer was used to compute averaged relativistic effective potentials (AREP) and spin‐orbit operators for the atoms Li through Ar. These are tabulated in analytic form. Small optimized Gaussian basis sets with expansion coefficients for the lowest energy state for each atom are given and the reliability of the potentials relative to all electric calculations is discussed. Finally a procedure for computing molecular moments and Breit corrections is suggested.

A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition.

Abstract: Epithelial-mesenchymal transition (EMT) is essential for organogenesis and is triggered during carcinoma progression to an invasive state. Transforming growth factor-beta (TGF-beta) cooperates with signalling pathways, such as Ras and Wnt, to induce EMT, but the molecular mechanisms are not clear. Here, we report that SMAD3 and SMAD4 interact and form a complex with SNAIL1, a transcriptional repressor and promoter of EMT. The SNAIL1-SMAD3/4 complex was targeted to the gene promoters of CAR, a tight-junction protein, and E-cadherin during TGF-beta-driven EMT in breast epithelial cells. SNAIL1 and SMAD3/4 acted as co-repressors of CAR, occludin, claudin-3 and E-cadherin promoters in transfected cells. Conversely, co-silencing of SNAIL1 and SMAD4 by siRNA inhibited repression of CAR and occludin during EMT. Moreover, loss of CAR and E-cadherin correlated with nuclear co-expression of SNAIL1 and SMAD3/4 in a mouse model of breast carcinoma and at the invasive fronts of human breast cancer. We propose that activation of a SNAIL1-SMAD3/4 transcriptional complex represents a mechanism of gene repression during EMT.