Stockholm School of Economics

About: Stockholm School of Economics is a education organization based out in Stockholm, Sweden. It is known for research contribution in the topics: Population & Cost effectiveness. The organization has 1186 authors who have published 4891 publications receiving 285543 citations. The organization is also known as: Stockholm Business School & Handelshögskolan i Stockholm.

Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence

Abstract: Intelligence is associated with important economic and health-related life outcomes Despite intelligence having substantial heritability (054) and a confirmed polygenic nature, initial genetic studies were mostly underpowered Here we report a meta-analysis for intelligence of 78,308 individuals We identify 336 associated SNPs (METAL P < 5 × 10-8) in 18 genomic loci, of which 15 are new Around half of the SNPs are located inside a gene, implicating 22 genes, of which 11 are new findings Gene-based analyses identified an additional 30 genes (MAGMA P < 273 × 10-6), of which all but one had not been implicated previously We show that the identified genes are predominantly expressed in brain tissue, and pathway analysis indicates the involvement of genes regulating cell development (MAGMA competitive P = 35 × 10-6) Despite the well-known difference in twin-based heritability for intelligence in childhood (045) and adulthood (080), we show substantial genetic correlation (rg = 089, LD score regression P = 54 × 10-29) These findings provide new insight into the genetic architecture of intelligence

Key principles for the improved conduct of health technology assessments for resource allocation decisions.

Abstract: Health technology assessment (HTA) is a dynamic, rapidly evolving process, embracing different types of assessments that inform real-world decisions about the value (i.e., benefits, risks, and costs) of new and existing technologies. Historically, most HTA agencies have focused on producing high quality assessment reports that can be used by a range of decision makers. However, increasingly organizations are undertaking or commissioning HTAs to inform a particular resource allocation decision, such as listing a drug on a national or local formulary, defining the range of coverage under insurance plans, or issuing mandatory guidance on the use of health technologies in a particular healthcare system. A set of fifteen principles that can be used in assessing existing or establishing new HTA activities is proposed, providing examples from existing HTA programs. The principal focus is on those HTA activities that are linked to, or include, a particular resource allocation decision. In these HTAs, the consideration of both costs and benefits, in an economic evaluation, is critical. It is also important to consider the link between the HTA and the decision that will follow. The principles are organized into four sections: (i) "Structure" of HTA programs; (ii) "Methods" of HTA; (iii) "Processes for Conduct" of HTA; and (iv) "Use of HTAs in Decision Making."

Fracture risk following an osteoporotic fracture.

Abstract: The aim of this study was to examine the pattern of fracture risk following a prior fracture at the spine, shoulder or hip. We studied 1918 patients with fractures at these sites identified from the Department of Radiology in Malmo who were followed for 5 years. Poisson regression was used to compute fracture rates immediately after the initial fracture and at 5 years thereafter in men and women aged 60 or 80 years. Immediate fracture risk was higher than that of the general population, more markedly so at the age of 60 than at 80 years. At the age of 60 years, the risk of hip, forearm and spine fractures were significantly increased following a prior spine, hip or shoulder fracture in men. A similar pattern was seen in women, except that the increase in risk of forearm fracture following a spine or hip fracture was not statistically significant. The incidence of further fractures at the shoulder, spine or hip fell with time after the first fracture, a fall that was significant for all fractures after a shoulder fracture, hip fracture after a spine fracture, and hip and spine fractures after a hip fracture. We conclude that the risk of a subsequent fracture immediately after an osteoporotic fracture is highest immediately after the event. This provides a rationale for very early intervention immediately after fractures to avoid recurrent fractures.

Multinational Corporations and Productivity Convergence in Mexico

Abstract: Since the 1960s the developing countries have had very different experiences regarding income and productivity growth, and the extent to which they have converged on developed countries. Some, such as the Asian newly-industrialized countries (NICs), clearly are in a process of rapid convergence, whereas others, such as most countries in Africa, show no sign of convergence. This indicates that the realization of the potentiality for productivity catch-up simply because of backwardness depends strongly on another set of causes, some of which are internal and others external to the countries themselves (see Abramovitz, 1986).