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Institution

Stony Brook University

EducationStony Brook, New York, United States
About: Stony Brook University is a education organization based out in Stony Brook, New York, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 32534 authors who have published 68218 publications receiving 3035131 citations. The organization is also known as: State University of New York at Stony Brook & SUNY Stony Brook.


Papers
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Journal ArticleDOI
03 Sep 2004-Science
TL;DR: The evidence supports a model in which Argonaute contributes “Slicer” activity to RISC, providing the catalytic engine for RNAi.
Abstract: Gene silencing through RNA interference (RNAi) is carried out by RISC, the RNA-induced silencing complex. RISC contains two signature components, small interfering RNAs (siRNAs) and Argonaute family proteins. Here, we show that the multiple Argonaute proteins present in mammals are both biologically and biochemically distinct, with a single mammalian family member, Argonaute2, being responsible for messenger RNA cleavage activity. This protein is essential for mouse development, and cells lacking Argonaute2 are unable to mount an experimental response to siRNAs. Mutations within a cryptic ribonuclease H domain within Argonaute2, as identified by comparison with the structure of an archeal Argonaute protein, inactivate RISC. Thus, our evidence supports a model in which Argonaute contributes "Slicer" activity to RISC, providing the catalytic engine for RNAi.

2,704 citations

Journal ArticleDOI
28 Jun 2007-Nature
TL;DR: A family of miRNAs, miR-34a–c, whose expression reflected p53 status is described, whose encoded genes are direct transcriptional targets of p53, whose induction by DNA damage and oncogenic stress depends on p53 both in vitro and in vivo.
Abstract: A global decrease in microRNA (miRNA) levels is often observed in human cancers, indicating that small RNAs may have an intrinsic function in tumour suppression. To identify miRNA components of tumour suppressor pathways, we compared miRNA expression profiles of wild-type and p53-deficient cells. Here we describe a family of miRNAs, miR-34a-c, whose expression reflected p53 status. Genes encoding miRNAs in the miR-34 family are direct transcriptional targets of p53, whose induction by DNA damage and oncogenic stress depends on p53 both in vitro and in vivo. Ectopic expression of miR-34 induces cell cycle arrest in both primary and tumour-derived cell lines, which is consistent with the observed ability of miR-34 to downregulate a programme of genes promoting cell cycle progression. The p53 network suppresses tumour formation through the coordinated activation of multiple transcriptional targets, and miR-34 may act in concert with other effectors to inhibit inappropriate cell proliferation.

2,658 citations

Journal ArticleDOI
23 Jul 2004-Science
TL;DR: It is shown that large-scale copy number polymorphisms (CNPs) (about 100 kilobases and greater) contribute substantially to genomic variation between normal humans.
Abstract: The extent to which large duplications and deletions contribute to human genetic variation and diversity is unknown. Here, we show that large-scale copy number polymorphisms (CNPs) (about 100 kilobases and greater) contribute substantially to genomic variation between normal humans. Representational oligonucleotide microarray analysis of 20 individuals revealed a total of 221 copy number differences representing 76 unique CNPs. On average, individuals differed by 11 CNPs, and the average length of a CNP interval was 465 kilobases. We observed copy number variation of 70 different genes within CNP intervals, including genes involved in neurological function, regulation of cell growth, regulation of metabolism, and several genes known to be associated with disease.

2,572 citations

Journal ArticleDOI
K. Adcox1, S. S. Adler2, Serguei Afanasiev3, Christine Angela Aidala4  +550 moreInstitutions (48)
TL;DR: In this paper, the results of the PHENIX detector at the Relativistic Heavy Ion Collider (RHIC) were examined with an emphasis on implications for the formation of a new state of dense matter.

2,572 citations


Authors

Showing all 32829 results

NameH-indexPapersCitations
Zhong Lin Wang2452529259003
Dennis W. Dickson1911243148488
Hyun-Chul Kim1764076183227
David Baker1731226109377
J. N. Butler1722525175561
Roderick T. Bronson169679107702
Nora D. Volkow165958107463
Jovan Milosevic1521433106802
Thomas E. Starzl150162591704
Paolo Boffetta148145593876
Jacques Banchereau14363499261
Larry R. Squire14347285306
John D. E. Gabrieli14248068254
Alexander Milov142114393374
Meenakshi Narain1421805147741
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023124
2022453
20213,609
20203,747
20193,426
20183,127