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Institution

Stony Brook University

EducationStony Brook, New York, United States
About: Stony Brook University is a education organization based out in Stony Brook, New York, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 32534 authors who have published 68218 publications receiving 3035131 citations. The organization is also known as: State University of New York at Stony Brook & SUNY Stony Brook.


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Journal ArticleDOI
TL;DR: A refined functional SELEX screen for motifs that can act as ESEs in response to the human SR protein SF2/ASF is carried out and an increased specificity score matrix is derived that accurately predicts the exon-skipping phenotypes of deleterious point mutations.
Abstract: Numerous disease-associated point mutations exert their effects by disrupting the activity of exonic splicing enhancers (ESEs). We previously derived position weight matrices to predict putative ESEs specific for four human SR proteins. The score matrices are part of ESEfinder, an online resource to identify ESEs in query sequences. We have now carried out a refined functional SELEX screen for motifs that can act as ESEs in response to the human SR protein SF2/ASF. The test BRCA1 exon under selection was internal, rather than the 3'-terminal IGHM exon used in our earlier studies. A naturally occurring heptameric ESE in BRCA1 exon 18 was replaced with two libraries of random sequences, one seven nucleotides in length, the other 14. Following three rounds of selection for in vitro splicing via internal exon inclusion, new consensus motifs and score matrices were derived. Many winner sequences were demonstrated to be functional ESEs in S100-extract-complementation assays with recombinant SF2/ASF. Motif-score threshold values were derived from both experimental and statistical analyses. Motif scores were shown to correlate with levels of exon inclusion, both in vitro and in vivo. Our results confirm and extend our earlier data, as many of the same motifs are recognized as ESEs by both the original and our new score matrix, despite the different context used for selection. Finally, we have derived an increased specificity score matrix that incorporates information from both of our SF2/ASF-specific matrices and that accurately predicts the exon-skipping phenotypes of deleterious point mutations.

488 citations

Journal ArticleDOI
27 Jun 2014-Science
TL;DR: The results demonstrate the formation of a nonequilibrium solid solution phase, LixFePO4 (0 < x < 1), during high-rate cycling, with compositions that span the entire composition between two thermodynamic phases, LiFe PO4 and FePO4.
Abstract: The absence of a phase transformation involving substantial structural rearrangements and large volume changes is generally considered to be a key characteristic underpinning the high-rate capability of any battery electrode material. In apparent contradiction, nanoparticulate LiFePO4, a commercially important cathode material, displays exceptionally high rates, whereas its lithium-composition phase diagram indicates that it should react via a kinetically limited, two-phase nucleation and growth process. Knowledge concerning the equilibrium phases is therefore insufficient, and direct investigation of the dynamic process is required. Using time-resolved in situ x-ray powder diffraction, we reveal the existence of a continuous metastable solid solution phase during rapid lithium extraction and insertion. This nonequilibrium facile phase transformation route provides a mechanism for realizing high-rate capability of electrode materials that operate via two-phase reactions.

488 citations

Journal ArticleDOI
M. G. Aartsen1, K. Abraham2, Markus Ackermann, Jenni Adams3  +316 moreInstitutions (45)
TL;DR: In this article, the results from six different IceCube searches for astrophysical neutrinos in a maximum-likelihood analysis are combined, and the combined event sample features high-statistics samples of shower-like and track-like events.
Abstract: Evidence for an extraterrestrial flux of high-energy neutrinos has now been found in multiple searches with the IceCube detector. The first solid evidence was provided by a search for neutrino events with deposited energies greater than or similar to 30 TeV and interaction vertices inside the instrumented volume. Recent analyses suggest that the extraterrestrial flux extends to lower energies and is also visible with throughgoing, nu(mu)-induced tracks from the Northern Hemisphere. Here, we combine the results from six different IceCube searches for astrophysical neutrinos in a maximum-likelihood analysis. The combined event sample features high-statistics samples of shower-like and track-like events. The data are fit in up to three observables: energy, zenith angle, and event topology. Assuming the astrophysical neutrino flux to be isotropic and to consist of equal flavors at Earth, the all-flavor spectrum with neutrino energies between 25 TeV and 2.8 PeV is well described by an unbroken power law with best-fit spectral index -2.50 +/- 0.09 and a flux at 100 TeV of (6.7(-1.2)(+1.1)) x 10(-18) GeV-1 s(-1) sr(-1) cm(-2). Under the same assumptions, an unbroken power law with index -2 is disfavored with a significance of 3.8 sigma (p = 0.0066%) with respect to the best fit. This significance is reduced to 2.1 sigma (p = 1.7%) if instead we compare the best fit to a spectrum with index -2 that has an exponential cut-off at high energies. Allowing the electron-neutrino flux to deviate from the other two flavors, we find a nu(e) fraction of 0.18 +/- 0.11 at Earth. The sole production of electron neutrinos, which would be characteristic of neutron-decay-dominated sources, is rejected with a significance of 3.6 sigma ( p = 0.014%).

487 citations

Journal ArticleDOI
TL;DR: In this paper, the phase diagram of QCD with two massless quark flavors in the space of temperature $T$ and chemical potential of the baryon charge \ensuremath{\mu} was analyzed.
Abstract: We analyze the phase diagram of QCD with two massless quark flavors in the space of temperature $T$ and chemical potential of the baryon charge \ensuremath{\mu} using available experimental knowledge of QCD, insights gained from various models, as well as general and model independent arguments including continuity, universality, and thermodynamic relations. A random matrix model is used to describe the chiral symmetry restoration phase transition at finite $T$ and \ensuremath{\mu}. In agreement with general arguments, this model predicts a tricritical point in the $T\ensuremath{\mu}$ plane. Certain critical properties at such a point are universal and can be relevant to heavy ion collision experiments.

487 citations

Journal ArticleDOI
TL;DR: Results indicate that the N1 represents the earliest component modulated by emotional stimuli; the EPN and the LPP represent unique components; the scalp-recorded LPP appears to include a P3-like positivity as well as additional positivities at occipital and central recording sites.
Abstract: Consistent with the notion that emotional stimuli receive preferential attention and perceptual processing, many eventrelated potential (ERP) components appear sensitive to emotional stimuli. In an effort to differentiate components that are sensitive to emotional versus neutral stimuli, the current study utilized temporospatial principal components analysis to analyze ERPs from a large sample (N 5 82) while pleasant, neutral, and unpleasant images were passively viewed. Several factors sensitive to emotional stimuli were identifiedFcorresponding to the N1, early posterior negativity (EPN), and P3; multiple factors resembling the late positive potential (LPP) emerged. Results indicate that the N1 represents the earliest component modulated by emotional stimuli; the EPN and the LPP represent unique components; the scalp-recorded LPP appears to include a P3-like positivity as well as additional positivities at occipital and central recording sites.

486 citations


Authors

Showing all 32829 results

NameH-indexPapersCitations
Zhong Lin Wang2452529259003
Dennis W. Dickson1911243148488
Hyun-Chul Kim1764076183227
David Baker1731226109377
J. N. Butler1722525175561
Roderick T. Bronson169679107702
Nora D. Volkow165958107463
Jovan Milosevic1521433106802
Thomas E. Starzl150162591704
Paolo Boffetta148145593876
Jacques Banchereau14363499261
Larry R. Squire14347285306
John D. E. Gabrieli14248068254
Alexander Milov142114393374
Meenakshi Narain1421805147741
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023124
2022453
20213,609
20203,747
20193,426
20183,127