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Institution

Stony Brook University

EducationStony Brook, New York, United States
About: Stony Brook University is a education organization based out in Stony Brook, New York, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 32534 authors who have published 68218 publications receiving 3035131 citations. The organization is also known as: State University of New York at Stony Brook & SUNY Stony Brook.


Papers
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Book ChapterDOI
05 Sep 2010
TL;DR: This work focuses on discovering attributes and their visual appearance, and is as agnostic as possible about the textual description, and characterizes attributes according to their visual representation: global or local, and type: color, texture, or shape.
Abstract: It is common to use domain specific terminology - attributes - to describe the visual appearance of objects. In order to scale the use of these describable visual attributes to a large number of categories, especially those not well studied by psychologists or linguists, it will be necessary to find alternative techniques for identifying attribute vocabularies and for learning to recognize attributes without hand labeled training data. We demonstrate that it is possible to accomplish both these tasks automatically by mining text and image data sampled from the Internet. The proposed approach also characterizes attributes according to their visual representation: global or local, and type: color, texture, or shape. This work focuses on discovering attributes and their visual appearance, and is as agnostic as possible about the textual description.

483 citations

Journal ArticleDOI
TL;DR: In spite of persistent activation via phosphorylation, MAP kinase expression is upregulated 5-20-fold and this hyperexpression may be a critical element to initiation as well as the metastatic potential of various forms of human breast cancer.
Abstract: Mitogen-activated protein (MAP) kinases act as transducers of extracellular signaling via tyrosine kinase-growth factor receptors and G-protein-linked receptors to elements regulating transcription. The activity, abundance, and localization of MAP kinase was investigated in normal and malignant neoplasia of the breast. In carcinoma of the breast, MAP kinase was heavily phosphorylated on tyrosyl residues and its activity elevated 5-10-fold over benign conditions, such as fibroadenoma and fibrocystic disease. By in situ reverse transcription-polymerase chain reaction, hyperexpression of MAP kinase mRNA can be localized to malignant, epithelial cells. Metastatic cells within involved lymph nodes of patients with breast cancer also display hyperexpression of MAP kinase. In spite of persistent activation via phosphorylation, MAP kinase expression is upregulated 5-20-fold and this hyperexpression may be a critical element to initiation as well as the metastatic potential of various forms of human breast cancer.

482 citations

Journal ArticleDOI
TL;DR: Recent advances in tumor-targeting drug conjugates including monoclonal antibodies, polyunsaturated fatty acids, folic acid, hyaluronic acid, and oligopeptides are described as tumor- targeting moieties.

481 citations

Journal ArticleDOI
TL;DR: For example, Behr et al. as mentioned in this paper examined the relationship between real-world cues, television news coverage, and public concern for the issues of energy, inflation, and unemployment.
Abstract: This paper examines the interrelationships between real-world cues, television news coverage, and public concern for the issues of energy, inflation, and unemployment. On the basis of longitudinal data, the authors show that media agenda setting is indeed unidirectional-television news influences public concern and not vice versa. Lead stories are significantly more powerful than ordinary stories in shaping the public's agenda. Prevailing conditions and events affect public opinion both directly and indirectly, by determining the degree of news coverage accorded issues. Roy Behr is a Ph.D. candidate in political science at Yale University. Shanto lyengar is Associate Professor of Political Science at the State University of New York at Stony Brook. The authors are grateful to Bill Adams for providing research facilities at the George Washington University Library, and to Steven Rosenstone who contributed significantly to the preparation of this paper. An earlier version of this paper was presented at the 37th Annual Meeting of the American Association of Public Opinion Research, Hunt Valley, Maryland, May 20-23, 1982. Public Opinion Quarterly Vol. 49:38-57 C) by the Trustees of Columbia University Published by Elsevier Science Publishing Co., Inc. 0033-362X/85/0049-38/$2.50 This content downloaded from 207.46.13.129 on Mon, 27 Jun 2016 07:19:48 UTC All use subject to http://about.jstor.org/terms TV NEWS AND AGENDA SErTING 39 mediately before the election may have increased the importance voters assigned to foreign policy as a criterion for evaluating the presidential candidates. The election was thereby transformed into a referendum on the Carter Administration's foreign policy, with disastrous consequences for Carter's candidacy. Experimental studies tend to corroborate this argument; individuals exposed to more news about a particular issue come to assign greater weight to this issue when evaluating the incumbent president (see Iyengar, et al., 1984), and when formulating their voting choices (Iyengar and Kinder, 1984; Behr, 1984). In this article we rely on longitudinal data spanning seven years to investigate the public's concern for inflation, unemployment, and energy. Our analysis extends agenda-setting research into two hitherto unexplored areas. First, we trace public concern to both television news coverage and to prevailing conditions or events. Second, we investigate the impact of television news on public concern as well as the reciprocal impact of public concern on levels of news coverage. Limitations of Past Research Given the political ramifications of agenda-setting and the preeminence of television as a credible and trustworthy source of political information (see Bower, 1983), it is not surprising that a good deal of research has been directed at the agenda-setting effects of television news programs. These studies report a kaleidescope of findings. Some researchers claim that television news coverage has no impact on the audience's perceptions of issues (Patterson and McClure, 1976); others suggest that television lags behind newspapers as an agenda-setter (Benton and Frazier, 1976) and that the effects of television on perceptions of issue importance are limited to the least educated and informed segments of the citizenry (McCombs, 1976). Confusion over the agenda-setting power of television may simply be a product of methodological limitations. The cross-sectional sample survey favored by most researchers is hardly a powerful means of testing a dynamic process such as agenda-setting. A more appropriate strategy is to search for media effects over time, as news coverage and public concern evolve. Longitudinal studies of agenda-setting, though few in number, find that changes in the level of media attention do indeed produce changes in public concern for national issues (see MacKuen and Coombs, 1982). Similarly, experimental work demonstrates that network newscasts possess an uncanny capacity to shape viewers' political concerns (Iyengar, et al., 1982). In short, it is premature to dismiss television as a medium with little agenda-setting clout. Most research on agenda-setting is not only methodologically weak, it This content downloaded from 207.46.13.129 on Mon, 27 Jun 2016 07:19:48 UTC All use subject to http://about.jstor.org/terms 40 ROY L. BEHR AND SHANTO IYENGAR also suffers from conceptual limitations. Researchers ignore the effects of direct experience on individuals' political concerns (two exceptions are MacKuen and Coombs, 1982; Erbring, et al., 1980). While there can be no denying that citizens are highly dependent upon the media for public affairs information, personal experience too is a sufficiently credible source of information. Many national issues impinge on large numbers of individuals; some issues, including crime, civil rights, and unemployment have profound personal significance. Explanations of the "issueattention" cycle must therefore include both mediated and direct experiences; ignoring the latter may lead to notably exaggerated estimates of the effects of media. Prevailing circumstances and events can also affect individuals' political concerns indirectly by determining what the media pay attention to. As unemployment rises, the media may devote more time to unemployment and the public's concern for the issue rises. If this is the case, then agenda-setting represents the media alerting citizens to current realities. On the other hand, despite the claims of network executives that their newscasts are "mirror images" of current realities, news coverage of national issues may be quite indifferent to prevailing conditions. Media agendas may be determined instead by idiosyncratic editorial, organizational, or commercial imperatives (see Epstein, 1973; Altheide, 1976; Gans, 1980), thus diverting the public from the "real" problems facing the nation. In either event, it is imperative that indicators of national conditions be brought to bear on the relationship between news coverage and issue salience. Real-world indicators serve two purposes: first, to assess the sensitivity of television news coverage to current conditions and events; second, to distinguish between the effects of news coverage and realworld conditions on public concern for issues. Finally, agenda-setting researchers have generally ignored the critical question of causality. It is taken for granted that news coverage is the driving force and that agenda-setting is a unidirectional or recursive process. The possibility of a feedback effect, namely, that public concern itself spawns news coverage, is ignored. The networks may choose to broadcast stories that are of current interest to their viewers. Our analysis is sensitive to this possibility. We attempt to estimate the impact of news coverage on public concern as well as the impact of public concern on

481 citations

Journal ArticleDOI
TL;DR: In this paper, a new Monte Carlo simulation procedure is developed which is expected to produce more rapid convergence than the standard Metropolis method, and the trial particle moves are chosen in accord with a Brownian dynamics algorithm rather than at random.
Abstract: A new Monte Carlo simulation procedure is developed which is expected to produce more rapid convergence than the standard Metropolis method. The trial particle moves are chosen in accord with a Brownian dynamics algorithm rather than at random. For two model systems, a string of point masses joined by harmonic springs and a cluster of charged soft spheres, the new procedure is compared to the standard one and shown to manifest a more rapid convergence rate for some important energetic and structural properties.

481 citations


Authors

Showing all 32829 results

NameH-indexPapersCitations
Zhong Lin Wang2452529259003
Dennis W. Dickson1911243148488
Hyun-Chul Kim1764076183227
David Baker1731226109377
J. N. Butler1722525175561
Roderick T. Bronson169679107702
Nora D. Volkow165958107463
Jovan Milosevic1521433106802
Thomas E. Starzl150162591704
Paolo Boffetta148145593876
Jacques Banchereau14363499261
Larry R. Squire14347285306
John D. E. Gabrieli14248068254
Alexander Milov142114393374
Meenakshi Narain1421805147741
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023124
2022453
20213,609
20203,747
20193,426
20183,127