Sun Yat-sen University

About: Sun Yat-sen University is a education organization based out in Guangzhou, Guangdong, China. It is known for research contribution in the topics: Population & Cancer. The organization has 115149 authors who have published 113763 publications receiving 2286465 citations. The organization is also known as: Zhongshan University & SYSU.

Impact of coronavirus disease 2019 on pulmonary function in early convalescence phase.

Abstract: This study investigated the influence of Coronavirus Disease 2019 (COVID-19) on lung function in early convalescence phase A retrospective study of COVID-19 patients at the Fifth Affiliated Hospital of Sun Yat-sen University were conducted, with serial assessments including lung volumes (TLC), spirometry (FVC, FEV1), lung diffusing capacity for carbon monoxide (DLCO),respiratory muscle strength, 6-min walking distance (6MWD) and high resolution CT being collected at 30 days after discharged Fifty-seven patients completed the serial assessments There were 40 non-severe cases and 17 severe cases Thirty-one patients (543%) had abnormal CT findings Abnormalities were detected in the pulmonary function tests in 43 (754%) of the patients Six (105%), 5(87%), 25(438%) 7(123%), and 30 (526%) patients had FVC, FEV1, FEV1/FVC ratio, TLC, and DLCO values less than 80% of predicted values, respectively 28 (491%) and 13 (228%) patients had PImax and PEmax values less than 80% of the corresponding predicted values Compared with non-severe cases, severe patients showed higher incidence of DLCO impairment (756%vs425%, p = 0019), higher lung total severity score (TSS) and R20, and significantly lower percentage of predicted TLC and 6MWD No significant correlation between TSS and pulmonary function parameters was found during follow-up visit Impaired diffusing-capacity, lower respiratory muscle strength, and lung imaging abnormalities were detected in more than half of the COVID-19 patients in early convalescence phase Compared with non-severe cases, severe patients had a higher incidence of DLCO impairment and encountered more TLC decrease and 6MWD decline

A Novel Exfoliation Strategy to Significantly Boost the Energy Storage Capability of Commercial Carbon Cloth

Abstract: A facile and efficient electrochemical oxidation method to directly activated carbon cloth as an excellent electrode material for supercapacitors is reported. Flexible asymmetric supercapacitor devices based on activated carbon cloth anodes reach a remarkable energy density and excellent long-term durability.

Histone H3 trimethylation at lysine 36 guides m 6 A RNA modification co-transcriptionally

Abstract: DNA and histone modifications have notable effects on gene expression1. Being the most prevalent internal modification in mRNA, the N6-methyladenosine (m6A) mRNA modification is as an important post-transcriptional mechanism of gene regulation2–4 and has crucial roles in various normal and pathological processes5–12. However, it is unclear how m6A is specifically and dynamically deposited in the transcriptome. Here we report that histone H3 trimethylation at Lys36 (H3K36me3), a marker for transcription elongation, guides m6A deposition globally. We show that m6A modifications are enriched in the vicinity of H3K36me3 peaks, and are reduced globally when cellular H3K36me3 is depleted. Mechanistically, H3K36me3 is recognized and bound directly by METTL14, a crucial component of the m6A methyltransferase complex (MTC), which in turn facilitates the binding of the m6A MTC to adjacent RNA polymerase II, thereby delivering the m6A MTC to actively transcribed nascent RNAs to deposit m6A co-transcriptionally. In mouse embryonic stem cells, phenocopying METTL14 knockdown, H3K36me3 depletion also markedly reduces m6A abundance transcriptome-wide and in pluripotency transcripts, resulting in increased cell stemness. Collectively, our studies reveal the important roles of H3K36me3 and METTL14 in determining specific and dynamic deposition of m6A in mRNA, and uncover another layer of gene expression regulation that involves crosstalk between histone modification and RNA methylation. METTL14 recognizes the trimethyl mark on lysine 36 of histone H3 that directs m6A modifications co-transcriptionally.

Flexible Zn-Ion Batteries: Recent Progresses and Challenges.

Abstract: To keep pace with the increasing pursuit of portable and wearable electronics, it is urgent to develop advanced flexible power supplies. In this context, Zn-ion batteries (ZIBs) have garnered increasing attention as favorable energy storage devices for flexible electronics, owing to the high capacity, low cost, abundant resources, high safety, and eco-friendliness. Extensive efforts have been devoted to developing flexible ZIBs in the last few years. This work summarizes the recent achievements in the design, fabrication, and characterization of flexible ZIBs. Representative structures, such as sandwich and cable type, are particularly highlighted. Special emphasis is put on the novel design of electrolyte and electrode, which aims to endow reliable flexibility to the fabricated ZIBs. Moreover, current challenges and future opportunities for the development of high-performance flexible ZIBs are also outlined.