Sun Yat-sen University

About: Sun Yat-sen University is a education organization based out in Guangzhou, Guangdong, China. It is known for research contribution in the topics: Population & Cancer. The organization has 115149 authors who have published 113763 publications receiving 2286465 citations. The organization is also known as: Zhongshan University & SYSU.

A Novel Set-Based Particle Swarm Optimization Method for Discrete Optimization Problems

Abstract: Particle swarm optimization (PSO) is predominately used to find solutions for continuous optimization problems. As the operators of PSO are originally designed in an n-dimensional continuous space, the advancement of using PSO to find solutions in a discrete space is at a slow pace. In this paper, a novel set-based PSO (S-PSO) method for the solutions of some combinatorial optimization problems (COPs) in discrete space is presented. The proposed S-PSO features the following characteristics. First, it is based on using a set-based representation scheme that enables S-PSO to characterize the discrete search space of COPs. Second, the candidate solution and velocity are defined as a crisp set, and a set with possibilities, respectively. All arithmetic operators in the velocity and position updating rules used in the original PSO are replaced by the operators and procedures defined on crisp sets, and sets with possibilities in S-PSO. The S-PSO method can thus follow a similar structure to the original PSO for searching in a discrete space. Based on the proposed S-PSO method, most of the existing PSO variants, such as the global version PSO, the local version PSO with different topologies, and the comprehensive learning PSO (CLPSO), can be extended to their corresponding discrete versions. These discrete PSO versions based on S-PSO are tested on two famous COPs: the traveling salesman problem and the multidimensional knapsack problem. Experimental results show that the discrete version of the CLPSO algorithm based on S-PSO is promising.

Long non-coding RNA: a new player in cancer

Abstract: Emerging evidence showed that long non-coding RNAs (lncRNAs) play important roles in a wide range of biological processes and dysregulated lncRNAs are involved in many complex human diseases, including cancer. Although a few lncRNAs’ functions in cancer have been characterized, the detailed regulatory mechanisms of majority of lncRNAs in cancer initiation and progression remain largely unknown. In this review, we summarized recent progress on the mechanisms and functions of lncRNAs in cancer, especially focusing on the oncogenic and tumor suppressive roles of the newly identified lncRNAs, and the pathways these novel molecules might be involved in. Their potentials as biomarkers for diagnosis and prognosis in cancer are also discussed in this paper.

Do Bank Regulation, Supervision and Monitoring Enhance or Impede Bank Efficiency?

Abstract: The recent global financial crisis has spurred renewed interest in identifying those reforms in bank regulation that would work best to promote bank development, performance and stability. Building upon three recent world-wide surveys on bank regulation (Barth et al., 2004, 2006, and 2008), we attempt to contribute to this assessment by examining whether bank regulation, supervision and monitoring enhance or impede bank operating efficiency. Based on an unbalanced panel analysis of more than 4,050 banks observations in 72 countries over the time period 1999-2007, we find that tighter restrictions on bank activities are negatively associated with bank efficiency while greater capital regulation stringency is marginally and positively associated with bank efficiency. In addition, we find that a strengthening of official supervisory power is positively associated with bank efficiency only in countries with independent supervisory authorities. Moreover, independence coupled with a more experienced supervisory authority tends to enhance bank efficiency. Finally, market-based monitoring of banks in terms of more financial transparency is positively associated with bank efficiency.

Stimuli-Responsive Therapeutic Metallodrugs.

Abstract: The success of platinum-based anticancer agents has motivated the exploration of novel metal-based drugs for several decades, whereas problems such as drug-resistance and systemic toxicity hampered their clinical applications and efficacy. Stimuli-responsiveness of some metal complexes offers a good opportunity for designing site-specific prodrugs to maximize the therapeutic efficacy and minimize the side effect of metallodrugs. This review presents a comprehensive and up-to-date overview on the therapeutic stimuli-responsive metallodrugs that have appeared in the past two decades, where stimuli such as redox, pH, enzyme, light, temperature, and so forth were involved. The compounds are classified into three major categories based on the nature of stimuli, that is, endo-stimuli-responsive metallodrugs, exo-stimuli-responsive metallodrugs, and dual-stimuli-responsive metallodrugs. Representative examples of each type are discussed in terms of structure, response mechanism, and potential medical applications. In the end, future opportunities and challenges in this field are tentatively proposed. With diverse metal complexes being introduced, the foci of this review are pointed to platinum and ruthenium complexes.