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Institution

Sun Yat-sen University

EducationGuangzhou, Guangdong, China
About: Sun Yat-sen University is a education organization based out in Guangzhou, Guangdong, China. It is known for research contribution in the topics: Population & Cancer. The organization has 115149 authors who have published 113763 publications receiving 2286465 citations. The organization is also known as: Zhongshan University & SYSU.
Topics: Population, Cancer, Metastasis, Cell growth, Apoptosis


Papers
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Journal ArticleDOI
TL;DR: This review summarizes current knowledge of natural polyphenols, including resource, bioactivities, bioavailability and potential toxicity.
Abstract: The oxidative stress imposed by reactive oxygen species (ROS) plays an important role in many chronic and degenerative diseases. As an important category of phytochemicals, phenolic compounds universally exist in plants, and have been considered to have high antioxidant ability and free radical scavenging capacity, with the mechanism of inhibiting the enzymes responsible for ROS production and reducing highly oxidized ROS. Therefore, phenolic compounds have attracted increasing attention as potential agents for preventing and treating many oxidative stress-related diseases, such as cardiovascular diseases, cancer, ageing, diabetes mellitus and neurodegenerative diseases. This review summarizes current knowledge of natural polyphenols, including resource, bioactivities, bioavailability and potential toxicity.

568 citations

Journal ArticleDOI
TL;DR: The approach using angular ligand containing partially fixed TPE units paves a way toward highly porous MOFs with fluorescence turn-on response that will find wide applications in chemical sensing.
Abstract: We report a 2D layered metal–organic framework (MOF) with wide channels named NUS-1 and its activated analogue NUS-1a composed of Zn4O-like secondary building units and tetraphenylethene (TPE)-based ligand 4,4′-(2,2-diphenylethene-1,1-diyl)dibenzoic acid. Due to its special structure, NUS-1a exhibits unprecedented gas sorption behavior, glass-transition-like phase transition under cryogenic conditions, and responsive turn-on fluorescence to various volatile organic compounds. Our approach using angular ligand containing partially fixed TPE units paves a way toward highly porous MOFs with fluorescence turn-on response that will find wide applications in chemical sensing.

567 citations

Journal ArticleDOI
TL;DR: An overview of the utility of decarboxylative C-H bond functionalization in the synthesis of various organic compounds, such as styrenes, chalcones, biaryls, and heterocycles, is offered, covering most of the recent advances.
Abstract: C–H bond activation and decarboxylation are two significant processes in organic synthesis. The combination of these processes provides a novel synthetic strategy, that is, decarboxylative C–H bond functionalization. Considerable attention has been focused on such an active research field. This review offers an overview of the utility of decarboxylative C–H bond functionalization in the synthesis of various organic compounds, such as styrenes, chalcones, biaryls, and heterocycles, covering most of the recent advances of the decarboxylative functionalization of Csp–H, Csp2–H, and Csp3–H bonds, as well as their scopes, limitations, practical applications, and synthetic potentials.

567 citations

Journal ArticleDOI
TL;DR: This review summerized the biochemical and pharmacological functions of beta-carboline alkaloids and demonstrated a broad spectrum of pharmacological properties including sedative, anxiolytic, hypnotic, anticonvulsant, antitumor, antiviral, antiparasitic as well as antimicrobial activities.
Abstract: beta-Carboline alkaloids are a large group of natural and synthetic indole alkaloids with different degrees of aromaticity, some of which are widely distributed in nature, including various plants, foodstuffs, marine creatures, insects, mammalians as well as human tissues and body fluids. These compounds are of great interest due to their diverse biological activities. Particularly, these compounds have been shown to intercalate into DNA, to inhibit CDK, Topisomerase, and monoamine oxidase, and to interact with benzodiazepine receptors and 5-hydroxy serotonin receptors. Furthermore, these chemicals also demonstrated a broad spectrum of pharmacological properties including sedative, anxiolytic, hypnotic, anticonvulsant, antitumor, antiviral, antiparasitic as well as antimicrobial activities. In this review, we summerized the biochemical and pharmacological functions of beta-carboline alkaloids.

566 citations

Journal ArticleDOI
TL;DR: The fundamentals of EPSs including definitions, compositions and properties, and factors affecting EPSs production and characteristics are summarized and based on which, EPSs control towards membrane fouling mitigation in MBRs are comprehensively discussed.

564 citations


Authors

Showing all 115971 results

NameH-indexPapersCitations
Yi Chen2174342293080
Jing Wang1844046202769
Yang Gao1682047146301
Yang Yang1642704144071
Peter Carmeliet164844122918
Frank J. Gonzalez160114496971
Xiang Zhang1541733117576
Rui Zhang1512625107917
Seeram Ramakrishna147155299284
Joseph J.Y. Sung142124092035
Joseph Lau140104899305
Bin Liu138218187085
Georgios B. Giannakis137132173517
Kwok-Yung Yuen1371173100119
Shu Li136100178390
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20241
2023349
20221,547
202115,594
202013,929
201911,766