Institution
Sundaram Medical Foundation
Healthcare•Chennai, Tamil Nadu, India•
About: Sundaram Medical Foundation is a healthcare organization based out in Chennai, Tamil Nadu, India. It is known for research contribution in the topics: Population & Duchenne muscular dystrophy. The organization has 134 authors who have published 107 publications receiving 1552 citations. The organization is also known as: Dr. Rangarajan Memorial Hospital.
Topics: Population, Duchenne muscular dystrophy, Multiplex ligation-dependent probe amplification, Health care, Hemodialysis
Papers published on a yearly basis
Papers
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TL;DR: BAL findings provide only limited prognostic information in SSc-ILD, but neutrophilia on BAL is linked to early mortality, but BAL findings are not linked to long-term survival or the rapidity of progression of lung disease.
Abstract: Objective
To evaluate the prognostic value of bronchoalveolar lavage (BAL) cellular profiles in patients with systemic sclerosis–associated interstitial lung disease (SSc-ILD)
Methods
BAL cellularity was examined in relation to mortality (n = 141), serial pulmonary function findings (n = 134), and “progression-free survival” (n = 134), by proportional hazards analysis Baseline severity was quantified according to the extent of disease on high-resolution computed tomography, the diffusing capacity for carbon monoxide, and the presence or absence of pulmonary hypertension Mortality was subclassified into overall mortality (during 10 years of followup), early mortality (occurring within 2 years of presentation), and late mortality (occurring 2–10 years after presentation)
Results
Overall mortality was associated with neutrophilia on BAL (hazard ratio 223 [95% confidence interval 120–414], P = 001), but this effect was lost when disease severity was taken into account Early mortality was associated with neutrophilia on BAL (hazard ratio 840 [95% confidence interval 191–3695], P = 0005), independent of disease severity Late mortality was not associated with neutrophilia on BAL The presence of neutrophilia on BAL was not associated with time to decline in pulmonary function or progression-free survival Neither eosinophilia nor lymphocytosis on BAL was associated with mortality, rapidity of functional deterioration, or progression-free survival These findings were unaltered when treatment status was taken into account
Conclusion
BAL findings provide only limited prognostic information in SSc-ILD Neutrophilia on BAL is linked to early mortality, but BAL findings are not linked to long-term survival or the rapidity of progression of lung disease The usefulness of BAL to define alveolitis in SSc is questionable
155 citations
Fortis Healthcare1, Narayana Health2, King George's Medical University3, St. John's Medical College4, Kempegowda Institute of Medical Sciences5, JSS Medical College6, Apollo Hospitals7, Burdwan Medical College8, Sundaram Medical Foundation9, All India Institute of Medical Sciences10, Artemis11, Sarojini Naidu Medical College12, Government Medical College, Kottayam13, Deccan College of Medical Sciences14, National University of Ireland, Galway15, University of Dundee16, University of Barcelona17, Newcastle University18, Freeman Hospital19, University of Milan20, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico21
TL;DR: Patients with bronchiectasis in India have more severe disease and have distinct characteristics from those reported in other countries, and this study provides a benchmark to improve quality of care for patients with bronchopulmonary aspergillosis.
112 citations
TL;DR: Comparing the findings in BMD to previously published DMD data, BMD patients have higher proportions of duplications, a different distribution of mutations, and higher exception to the reading frame rule.
Abstract: Becker muscular dystrophy (BMD) is a milder form of X-linked Duchenne muscular dystrophy (DMD). Here, we report a study of 75 patients with immunoblot and/or immunostaining findings of muscle biopsy consistent with BMD (abnormal dystrophin). We utilized multiplex ligation dependent probe amplification (MLPA) on genomic DNA (gDNA) to screen all 79 exons for both deletions and duplications. A total of 19 patients testing negative for MLPA mutations were tested for mRNA splicing abnormalities using cDNA-MLPA on muscle biopsy. Complete cDNA sequencing was done on MLPA-negative patients. We identified disease-causing mutations in 66 (88%) of the patients. Of the mutation-positive patients, 42 (64%) showed deletions of one or more exons, 14 (21%) showed duplications, and 10 (15%) showed various mutations detected by cDNA-MLPA and sequencing studies. We found a high rate of "exceptions" to the reading frame rule in this BMD series (out-of-frame BMD; 17/56 deletions/duplications; 30%). This was partly explained by the high incidence of 5' gene deletions in BMD patients (a region known to be a hotspot for exceptions), and due to complex splicing patterns in which a subset of transcripts showed deletions larger than gDNA (exon-skipping). Comparing our findings in BMD to previously published DMD data, BMD patients have higher proportions of duplications, a different distribution of mutations, and higher exception to the reading frame rule.
77 citations
TL;DR: There is a serious need to review the neurobiological issue of smoking in schizophrenia considering the influence culture and social practices could have upon the behaviour.
75 citations
Children's National Medical Center1, University of Pittsburgh2, University of Alberta3, Veterans Health Administration4, University of California, Davis5, Boston Children's Hospital6, Sundaram Medical Foundation7, University of Toronto8, Alberta Children's Hospital9, Royal Children's Hospital10, Fundación Favaloro11, Mayo Clinic12, Washington University in St. Louis13, University Of Tennessee System14, University of Sydney15, University of Puerto Rico16, Baylor College of Medicine17, University of Minnesota18
TL;DR: Cardiomyopathy is a common cause of morbidity and death in patients with Duchenne muscular dystrophy (DMD) as discussed by the authors, and it is a cause of lung cancer.
Abstract: Introduction
Cardiomyopathy is a common cause of morbidity and death in patients with Duchenne muscular dystrophy (DMD).
71 citations
Authors
Showing all 134 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Madhukar Pai | 89 | 522 | 33349 |
| Tirupati N. Srinivasan | 22 | 54 | 1484 |
| Venkatakrishna Rajajee | 20 | 69 | 1818 |
| Raju Poddar | 14 | 69 | 546 |
| Shriraam Mahadevan | 13 | 83 | 422 |
| R. Periyasamy | 12 | 31 | 363 |
| Malathi Sathiyasekaran | 9 | 27 | 232 |
| So Shivbalan | 9 | 26 | 276 |
| Suresh Sankarasubbaiyan | 6 | 6 | 169 |
| Arjun Rajagopalan | 6 | 7 | 184 |
| V. Sumathi | 5 | 7 | 69 |
| Kuruvilla Thomas | 5 | 9 | 48 |
| K. Krishna Kumar | 4 | 5 | 46 |
| R. Parivalavan | 3 | 3 | 105 |
| K. Ganapathy | 3 | 3 | 43 |