Showing papers by "Sungkyunkwan University published in 2008"

The CMS experiment at the CERN LHC

Abstract: The Compact Muon Solenoid (CMS) detector is described. The detector operates at the Large Hadron Collider (LHC) at CERN. It was conceived to study proton-proton (and lead-lead) collisions at a centre-of-mass energy of 14 TeV (5.5 TeV nucleon-nucleon) and at luminosities up to 10(34)cm(-2)s(-1) (10(27)cm(-2)s(-1)). At the core of the CMS detector sits a high-magnetic-field and large-bore superconducting solenoid surrounding an all-silicon pixel and strip tracker, a lead-tungstate scintillating-crystals electromagnetic calorimeter, and a brass-scintillator sampling hadron calorimeter. The iron yoke of the flux-return is instrumented with four stations of muon detectors covering most of the 4 pi solid angle. Forward sampling calorimeters extend the pseudo-rapidity coverage to high values (vertical bar eta vertical bar <= 5) assuring very good hermeticity. The overall dimensions of the CMS detector are a length of 21.6 m, a diameter of 14.6 m and a total weight of 12500 t.

Stretchable and foldable silicon integrated circuits.

Abstract: We have developed a simple approach to high-performance, stretchable, and foldable integrated circuits. The systems integrate inorganic electronic materials, including aligned arrays of nanoribbons of single crystalline silicon, with ultrathin plastic and elastomeric substrates. The designs combine multilayer neutral mechanical plane layouts and "wavy" structural configurations in silicon complementary logic gates, ring oscillators, and differential amplifiers. We performed three-dimensional analytical and computational modeling of the mechanics and the electronic behaviors of these integrated circuits. Collectively, the results represent routes to devices, such as personal health monitors and other biomedical devices, that require extreme mechanical deformations during installation/use and electronic properties approaching those of conventional systems built on brittle semiconductor wafers.

Benign and malignant thyroid nodules: US differentiation--multicenter retrospective study.

Abstract: Purpose: To retrospectively evaluate the diagnostic accuracy of ultrasonographic (US) criteria for the depiction of benign and malignant thyroid nodules by using tissue diagnosis as the reference standard. Materials and Methods: This study had institutional review board approval, and informed consent was waived. From January 2003 through June 2003, 8024 consecutive patients had undergone thyroid US at nine affiliated hospitals. A total of 831 patients (716 women, 115 men; mean age, 49.5 years ± 13.8 [standard deviation]) with 849 nodules (360 malignant, 489 benign) that were diagnosed at surgery or biopsy were included in this study. Three radiologists retrospectively evaluated the following characteristics on US images: nodule size, presence of spongiform appearance, shape, margin, echotexture, echogenicity, and presence of microcalcification, macrocalcification, or rim calcification. A χ2 test and multiple regression analysis were performed. Sensitivity, specificity, and positive and negative predictive...

Screening for gastric cancer in Asia: current evidence and practice

Abstract: Gastric cancer is the second most common cause of death from cancer in Asia. Although surgery is the standard treatment for this disease, early detection and treatment is the only way to reduce mortality. This Review summarises the epidemiology of gastric cancer, and the evidence for, and current practices of, screening in Asia. Few Asian countries have implemented a national screening programme for gastric cancer; most have adopted opportunistic screening of high-risk individuals only. Although screening by endoscopy seems to be the most accurate method for detection of gastric cancer, the availability of endoscopic instruments and expertise for mass screening remains questionable--even in developed countries such as Japan. Therefore, barium studies or serum-pepsinogen testing are sometimes used as the initial screening tool in some countries, and patients with abnormal results are screened by endoscopy. Despite the strong link between infection with Helicobacter pylori and gastric cancer, more data are needed to define the role of its eradication in the prevention of gastric cancer in Asia. At present, there is a paucity of quality data from Asia to lend support for screening for gastric cancer.

Stents versus Coronary-Artery Bypass Grafting for Left Main Coronary Artery Disease

Abstract: In the overall matched cohort, there was no significant difference between the stenting and CABG groups in the risk of death (hazard ratio for the stenting group, 1.18; 95% confidence interval [CI], 0.77 to 1.80) or the risk of the composite outcome (hazard ratio for the stenting group, 1.10; 95% CI, 0.75 to 1.62). The rates of target-vessel revascularization were significantly higher in the group that received stents than in the group that underwent CABG (hazard ratio, 4.76; 95% CI, 2.80 to 8.11). Comparisons of the group that received bare-metal stents with the group that underwent CABG and of the group that received drug-eluting stents with the group that underwent CABG produced similar results, although there was a trend toward higher rates of death and the composite end point in the group that received drug-eluting stents. CONCLUSIONS In a cohort of patients with unprotected left main coronary artery disease, we found no significant difference in rates of death or of the composite end point of death, Q-wave myocardial infarction, or stroke between patients receiving stents and those undergoing CABG. However, stenting, even with drug-eluting stents, was associated with higher rates of target-vessel revascularization than was CABG.

Idiopathic nonspecific interstitial pneumonia: Report of an American thoracic society project

Abstract: Rationale: The American Thoracic Society/European Respiratory Society International Consensus Classification panel identified the clinical entity idiopathic nonspecific interstitial pneumonia (NSIP) as a provisional diagnosis and recommended further study.Objectives: We hypothesized that idiopathic NSIP is an autoimmune disease and the lung manifestation of undifferentiated connective tissue disease (UCTD), a recently described, distinct entity.Methods: We studied 28 consecutive patients with idiopathic interstitial pneumonia (IIP) enrolled in the University of California, San Francisco Interstitial Lung Disease Center who met prespecified criteria for UCTD, as follows: at least one clinical manifestation of connective tissue disease, serologic evidence of systemic inflammation in the absence of clinical infection, and absence of sufficient American College of Rheumatology criteria for another connective tissue disease. Medical record reviews, evaluation of radiographs, and scoring of lung biopsies were p...

CHEF: Cluster Head Election mechanism using Fuzzy logic in Wireless Sensor Networks

Abstract: In designing the wireless sensor networks, the energy is the most important consideration because the lifetime of the sensor node is limited by the battery of it. To overcome this demerit many research have been done. The clustering is the one of the representative approaches. In the clustering, the cluster heads gather data from nodes, aggregate it and send the information to the base station. In this way, the sensor nodes can reduce communication overheads that may be generated if each sensor node reports sensed data to the base station independently. LEACH is one of the most famous clustering mechanisms. It elects a cluster head based on probability model. This approach may reduce the network lifetime because LEACH does not consider the distribution of sensor nodes and the energy remains of each node. However, using the location and the energy information in the clustering can generate big overheads. In this paper we introduce CHEF - cluster head election mechanism using fuzzy logic. By using fuzzy logic, collecting and calculating overheads can be reduced and finally the lifetime of the sensor networks can be prolonged. To prove efficiency of CHEF, we simulated CHEF compared with LEACH using the matlab. Our simulation results show that CHEF is about 22.7% more efficient than LEACH.

Observation of a Resonancelike Structure in the π +- ψ ' Mass Distribution in Exclusive B→Kπ +- ψ ' Decays

Abstract: Reference EPFL-ARTICLE-154575doi:10.1103/PhysRevLett.100.142001View record in Web of Science Record created on 2010-11-05, modified on 2017-12-10

Nitridation-Driven Conductive Li4Ti5O12 for Lithium Ion Batteries

Abstract: To modify oxide structure and introduce a thin conductive film on Li4Ti5O12, thermal nitridation was adopted for the first time. NH3 decomposes surface Li4Ti5O12 to conductive TiN at high temperature, and surprisingly, it also modifies the surface structure in a way to accommodate the single phase Li insertion and extraction. The electrochemically induced Li4+δTi5O12 with a TiN coating layer shows great electrochemical properties at high current densities.

Theoretical and Experimental Studies of Bending of Inorganic Electronic Materials on Plastic Substrates

Abstract: This paper describes materials and mechanics aspects of bending in systems consisting of ribbons and bars of single crystalline silicon supported by sheets of plastic. The combined experimental and theoretical results provide an understanding for the essential behaviors and for mechanisms associated with layouts that achieve maximum bendability. Examples of highly bendable silicon devices on plastic illustrate some of these concepts. Although the studies presented here focus on ribbons and bars of silicon, the same basic considerations apply to other implementations of inorganic materials on plastic substrates, ranging from amorphous or polycrystalline thin films, to collections of nanowires and nanoparticles. The contents are, as a result, relevant to the growing community of researchers interested in the use of inorganic materials in flexible electronics.

Asian diagnostic criteria for autoimmune pancreatitis: consensus of the Japan-Korea Symposium on Autoimmune Pancreatitis.

Abstract: In 2002, the Japan Pancreas Society (JPS) was the first in the world to propose diagnostic criteria for autoimmune pancreatitis (AIP) Since the concept of AIP has changed with the accumulation of AIP cases, the Research Committee of Intractable Pancreatic Diseases (RCIPD) provided by the Ministry of Health, Labour and Welfare of Japan and the JPS issued revised clinical diagnostic criteria of AIP in 2006 The Asan Medical Center of Korea also proposed diagnostic criteria for AIP in 2006 However, there are subtle but clinically challenging differences between the Japanese and Korean criteria This inconsistency makes it difficult to compare data in studies from different centers and elucidate the characteristics of AIP To reach a consensus on AIP, the RCIPD and the Korean Society of Pancreatobiliary Diseases established the following Asian criteria for the diagnosis of AIP: I-1 Imaging studies of pancreatic parenchyma show a diffuse/segmental/focally enlarged gland, occasionally with a mass and/or a hypoattenuation rim I-2 Imaging studies of pancreaticobiliary ducts show diffuse/segmental/focal pancreatic ductal narrowing, often with stenosis of the bile duct (Both I-1 and I-2 are required for diagnosis) II Elevated level of serum IgG or IgG4, and detection of autoantibodies III Common lymphoplasmacytic infiltration and fibrosis, with abundant IgG4-positive cell infiltration AIP should be diagnosed when criterion I and one of the other two criteria are satisfied, or when histology shows the presence of lymphoplasmacytic sclerosing pancreatitis in the resected pancreas A diagnostic trial of steroid therapy can be applied carefully by expert pancreatologists only in patients fulfilling criterion I alone with negative diagnostic work-up results for pancreatobiliary cancer

Addressing cold-start problem in recommendation systems

Abstract: Recommender systems for automatically suggested items of interest to users have become increasingly essential in fields where mass personalization is highly valued. The popular core techniques of such systems are collaborative filtering, content-based filtering and combinations of these. In this paper, we discuss hybrid approaches, using collaborative and also content data to address cold-start - that is, giving recommendations to novel users who have no preference on any items, or recommending items that no user of the community has seen yet. While there have been lots of studies on solving the item-side problems, solution for user-side problems has not been seen public. So we develop a hybrid model based on the analysis of two probabilistic aspect models using pure collaborative filtering to combine with users' information. The experiments with MovieLen data indicate substantial and consistent improvements of this model in overcoming the cold-start user-side problem.

Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability

Abstract: The angiogenic sprout has been compared to the growing axon, and indeed, many proteins direct pathfinding by both structures. The Roundabout (Robo) proteins are guidance receptors with well-established functions in the nervous system; however, their role in the mammalian vasculature remains ill defined. Here we show that an endothelial-specific Robo, Robo4, maintains vascular integrity. Activation of Robo4 by Slit2 inhibits vascular endothelial growth factor (VEGF)-165-induced migration, tube formation and permeability in vitro and VEGF-165-stimulated vascular leak in vivo by blocking Src family kinase activation. In mouse models of retinal and choroidal vascular disease, Slit2 inhibited angiogenesis and vascular leak, whereas deletion of Robo4 enhanced these pathologic processes. Our results define a previously unknown function for Robo receptors in stabilizing the vasculature and suggest that activating Robo4 may have broad therapeutic application in diseases characterized by excessive angiogenesis and/or vascular leak.

Simple Synthesis of Functionalized Superparamagnetic Magnetite/Silica Core/Shell Nanoparticles and their Application as Magnetically Separable High‐Performance Biocatalysts

Abstract: Uniformly sized silica-coated magnetic nanoparticles (magnetite@silica) are synthesized in a simple one-pot process using reverse micelles as nanoreactors. The core diameter of the magnetic nanoparticles is easily controlled by adjusting the w value ([polar solvent]/[surfactant]) in the reverse-micelle solution, and the thickness of the silica shell is easily controlled by varying the amount of tetraethyl orthosilicate added after the synthesis of the magnetite cores. Several grams of monodisperse magnetite@silica nanoparticles can be synthesized without going through any size-selection process. When crosslinked enzyme molecules form clusters on the surfaces of the magnetite@silica nanoparticles, the resulting hybrid composites are magnetically separable, highly active, and stable under harsh shaking conditions for more than 15 days. Conversely, covalently attached enzymes on the surface of the magnetite@silica nanoparticles are deactivated under the same conditions.

Alternative Origins to Interorganizational Trust: An Interdependence Perspective on the Shadow of the Past and the Shadow of the Future

Abstract: Despite the widespread acceptance of trust as an informal governance institution, our understanding of its origins is nascent. Our review of the literature identified two distinct explanations: Trust emerges from either a shadow of the past (i.e., prior history) or a shadow of the future (i.e., expectations of continuity). In this paper we develop and empirically examine a third perspective: The potential interdependence of these two explanations. Our results strongly endorse this third perspective. We find that prior history does not directly affect trust; instead, the observed positive relationship between the two is mediated by expectations of continuity. Consistent with this result, analyses further show that a longer prior history makes the effect of continuity on trust much stronger than a shorter prior history. We interpret these findings as suggesting: (1) the criticality and centrality of a shadow of the future (i.e., a forward-looking calculus) in generating trust in interorganizational exchanges and (2) that a shadow of the past plays a facilitating, albeit indirect, role in trust building. Our conceptual model also extends the conventional use of the transaction cost logic to show how reciprocal investments in asset specificity and uncertainty drive expectations of continuity, and consequently, interorganizational trust. Our results also show, unexpectedly, that prior history has a direct negative effect on trust after specifying the mediating path of continuity. Our moderation analysis indicates when this effect occurs: When weak expectations of continuity exist, trust is lower for exchanges characterized by a longer prior history, suggesting a potential darkside of overembedded ties.

A case for flash memory ssd in enterprise database applications

Abstract: Due to its superiority such as low access latency, low energy consumption, light weight, and shock resistance, the success of flash memory as a storage alternative for mobile computing devices has been steadily expanded into personal computer and enterprise server markets with ever increasing capacity of its storage. However, since flash memory exhibits poor performance for small-to-moderate sized writes requested in a random order, existing database systems may not be able to take full advantage of flash memory without elaborate flash-aware data structures and algorithms. The objective of this work is to understand the applicability and potential impact that flash memory SSD (Solid State Drive) has for certain type of storage spaces of a database server where sequential writes and random reads are prevalent. We show empirically that up to more than an order of magnitude improvement can be achieved in transaction processing by replacing magnetic disk with flash memory SSD for transaction log, rollback segments, and temporary table spaces.

Lung Function Changes in Sprague-Dawley Rats After Prolonged Inhalation Exposure to Silver Nanoparticles

Abstract: The antimicrobial activity of silver nanoparticles has resulted in their widespread use in many consumer products. However, despite the continuing increase in the population exposed to silver nanoparticles, the effects of prolonged exposure to silver nanoparticles have not been thoroughly determined. Accordingly, this study attempted to investigate the inflammatory responses and pulmonary function changes in rats during 90 days of inhalation exposure to silver nanoparticles. The rats were exposed to silver nanoparticles (18 nm diameter) at concentrations of 0.7 x 10(6) particles/cm(3) (low dose), 1.4 x 10(6) particles /cm(3) (middle dose), and 2.9 x 10(6) particles /cm(3) (high dose) for 6 h/day in an inhalation chamber for 90 days. The lung function was measured every week after the daily exposure, and the animals sacrificed after the 90-day exposure period. Cellular differential counts and inflammatory measurements, such as albumin, lactate dehydrogenase (LDH), and total protein, were also monitored in the acellular bronchoalveolar lavage (BAL) fluid of the rats exposed to the silver nanoparticles for 90 days. Among the lung function test measurements, the tidal volume and minute volume showed a statistically significant decrease during the 90 days of silver nanoparticle exposure. Although no statistically significant differences were found in the cellular differential counts, the inflammation measurements increased in the high-dose female rats. Meanwhile, histopathological examinations indicated dose-dependent increases in lesions related to silver nanoparticle exposure, such as infiltrate mixed cell and chronic alveolar inflammation, including thickened alveolar walls and small granulomatous lesions. Therefore, when taken together, the decreases in the tidal volume and minute volume and other inflammatory responses after prolonged exposure to silver nanoparticles would seem to indicate that nanosized particle inhalation exposure can induce lung function changes, along with inflammation, at much lower mass dose concentrations when compared to submicrometer particles.

LAST: locality-aware sector translation for NAND flash memory-based storage systems

Abstract: As flash memory technologies quickly improve, NAND flash memory-based storage devices are becoming a viable alternative as a secondary storage solution for general-purpose computing systems such as personal computers and enterprise server systems. Most existing flash translation layer (FTL) schemes are, however, ill-suited for such systems because they were optimized for storage write patterns of embedded systems only. In this paper, we propose a new flash management technique called LAST which is optimized for access characteristics of general-purpose computing systems. By exploiting the locality of storage access patterns, LAST reduces the garbage collection overhead significantly, thus increasing the I/O performance of flash-based storage devices. Our experimental results show that the proposed technique reduces the garbage collection overhead by 54% over the existing flash memory management techniques.

Monitoring Multiwalled Carbon Nanotube Exposure in Carbon Nanotube Research Facility

Abstract: With the increased production and widespread use of multiwalled carbon nanotubes (MWCNTs), human and environmental exposure to MWCNTs is inevitably increasing. Therefore, this study monitored the possible exposure to MWCNT release in a carbon nanotube research laboratory. To estimate the potential exposure of researchers and evaluate the improvement of the workplace environment after the implementation of protective control measures, personal and area monitoring were conducted in an MWCNT research facility where the researchers handled unrefined materials. The number, composition, and aspect ratio of MWCNTs were measured using scanning transmission electron microscopy with an energy-dispersive x-ray analyzer. The gravimetric concentrations of total dust before any control measures ranged from 0.21 to 0.43 mg/m(3), then decreased to a nondetectable level after implementing the control measures. The number of MWCNTs in the samples obtained from the MWCNT blending laboratory ranged from 172.9 to 193.6 MWCNTs/cc before the control measures, and decreased to 0.018-0.05 MWCNTs/cc after the protective improvements. The real-time monitoring of aerosol particles provided a signature of the MWCNTs released from the blending equipment in laboratory C. In particular, the number size response of an aerodynamic particle sizer with a relatively high concentration in the range of 2 to 3 microm in aerodynamic diameter revealed the evidence of MWCNT exposure. The black carbon mass concentration also increased significantly during the MWCNT release process. Therefore, the present study suggests that the conventional industrial hygiene measures can significantly reduce exposure to airborne MWCNTs and other particulate materials in a nano research facility.

Semiconductor Wires and Ribbons for High- Performance Flexible Electronics

Abstract: This article reviews the properties, fabrication and assembly of inorganic semiconductor materials that can be used as active building blocks to form high-performance transistors and circuits for flexible and bendable large-area electronics. Obtaining high performance on low temperature polymeric substrates represents a technical challenge for macroelectronics. Therefore, the fabrication of high quality inorganic materials in the form of wires, ribbons, membranes, sheets, and bars formed by bottom-up and top-down approaches, and the assembly strategies used to deposit these thin films onto plastic substrates will be emphasized. Substantial progress has been made in creating inorganic semiconducting materials that are stretchable and bendable, and the description of the mechanics of these form factors will be presented, including circuits in three-dimensional layouts. Finally, future directions and promising areas of research will be described.

Giant magneto-elastic coupling in multiferroic hexagonal manganites

Abstract: The motion of atoms in a solid always responds to cooling or heating in a way that is consistent with the symmetry of the given space group of the solid to which they belong1,2. When the atoms move, the electronic structure of the solid changes, leading to different physical properties. Therefore, the determination of where atoms are and what atoms do is a cornerstone of modern solid-state physics. However, experimental observations of atomic displacements measured as a function of temperature are very rare, because those displacements are, in almost all cases, exceedingly small3,4,5. Here we show, using a combination of diffraction techniques, that the hexagonal manganites RMnO3 (where R is a rare-earth element) undergo an isostructural transition with exceptionally large atomic displacements: two orders of magnitude larger than those seen in any other magnetic material, resulting in an unusually strong magneto-elastic coupling. We follow the exact atomic displacements of all the atoms in the unit cell as a function of temperature and find consistency with theoretical predictions based on group theories. We argue that this gigantic magneto-elastic coupling in RMnO3 holds the key to the recently observed magneto-electric phenomenon in this intriguing class of materials6.

Payout Policy and Cash-Flow Uncertainty

Abstract: The importance of cash-flow uncertainty in payout policy has received little attention in empirical studies, while survey studies such as Linter (1956) and Brav, Graham, Harvey and Michaely (2005) indicate its importance. We conduct comprehensive analysis of its importance in payout policy. With worldwide firm-level data, we present evidence that cash-flow uncertainty is an important cross-sectional determinant of corporate payout policy. Our results show that, across countries, cash-flow uncertainty (represented by stock return volatility) is a key factor that affects the amount of dividends as well as the probability of paying dividends. The impact of cash-flow uncertainty on dividends is generally stronger than the impact of other potential determinants of payout policy - such as the earned/contributed capital mix, agency conflicts, investment opportunities, firm size, and profitability. Furthermore, cash-flow uncertainty also has a significant impact on the amount of total payouts (i.e., the sum of dividends and repurchases).

Joint rate and power allocation for cognitive radios in dynamic spectrum access environment

Abstract: We investigate the dynamic spectrum sharing problem among primary and secondary users in a cognitive radio network. We consider the scenario where primary users exhibit on-off behavior and secondary users are able to dynamically measure/estimate sum interference from primary users at their receiving ends. For such a scenario, we solve the problem of fair spectrum sharing among secondary users subject to their QoS constraints (in terms of minimum SINR and transmission rate) and interference constraints for primary users. Since tracking channel gains instantaneously for dynamic spectrum allocation may be very difficult in practice, we consider the case where only mean channel gains averaged over short-term fading are available. Under such scenarios, we derive outage probabilities for secondary users and interference constraint violation probabilities for primary users. Based on the analysis, we develop a complete framework to perform joint admission control and rate/power allocation for secondary users such that both QoS and interference constraints are only violated within desired limits. Throughput performance of primary and secondary networks is investigated via extensive numerical analysis considering different levels of implementation complexity due to channel estimation.

Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancer.

Abstract: MicroRNAs are small, non-coding RNAs that influence gene regulatory networks by post-transcriptional regulation of specific messenger RNA targets. MicroRNA expression is dysregulated in human malignancies, frequently leading to loss of expression of certain microRNAs. We report that expression of hsa-miR-342, a microRNA encoded in an intron of the gene EVL, is commonly suppressed in human colorectal cancer. The expression of hsa-miR-342 is coordinated with that of EVL and our results indicate that the mechanism of silencing is CpG island methylation upstream of EVL. We found methylation at the EVL/hsa-miR-342 locus in 86% of colorectal adenocarcinomas and in 67% of adenomas, indicating that it is an early event in colorectal carcinogenesis. In addition, we observed a higher frequency of methylation (56%) in histologically normal colorectal mucosa from individuals with concurrent cancer compared to mucosa from individuals without colorectal cancer (12%), suggesting the existence of a 'field defect' involving methylated EVL/hsa-miR-342. Furthermore, reconstitution of hsa-miR-342 in the colorectal cancer cell line HT-29 induced apoptosis, suggesting that this microRNA could function as a proapoptotic tumor suppressor. In aggregate, these results support a novel mechanism for silencing intronic microRNAs in cancer by epigenetic alterations of cognate host genes.