Sungkyunkwan University

About: Sungkyunkwan University is a education organization based out in Seoul, South Korea. It is known for research contribution in the topics: Thin film & Graphene. The organization has 28229 authors who have published 56428 publications receiving 1352733 citations. The organization is also known as: 성균관대학교.

DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load

Abstract: Mitotic cell division increases tumour mutation burden and copy number load, predictive markers of the clinical benefit of immunotherapy. Cell division correlates also with genomic demethylation involving methylation loss in late-replicating partial methylation domains. Here we find that immunomodulatory pathway genes are concentrated in these domains and transcriptionally repressed in demethylated tumours with CpG island promoter hypermethylation. Global methylation loss correlated with immune evasion signatures independently of mutation burden and aneuploidy. Methylome data of our cohort (n = 60) and a published cohort (n = 81) in lung cancer and a melanoma cohort (n = 40) consistently demonstrated that genomic methylation alterations counteract the contribution of high mutation burden and increase immunotherapeutic resistance. Higher predictive power was observed for methylation loss than mutation burden. We also found that genomic hypomethylation correlates with the immune escape signatures of aneuploid tumours. Hence, DNA methylation alterations implicate epigenetic modulation in precision immunotherapy. Demethylation of the genome is found in cancer. Here, the authors show that genomic demethylation entails changes in promoter methylation and gene expression associated with immune escape and suggest that the epigenetic alterations may be an important determinant of responses to immunotherapy.

Above 30% external quantum efficiency in green delayed fluorescent organic light-emitting diodes.

Abstract: Highly efficient green thermally activated delayed fluorescent organic light-emitting diodes with an external quantum efficiency of 31.2% were investigated by using 3-(3-(carbazole-9-yl)phenyl) pyrido[3′,2′:4,5]furo[2,3-b]pyridine (3CzPFP) derived from carbazole and pyrido[3′,2′:4,5]furo[2,3-b]pyridine. The host material showed well-matched photoluminescence emission with absorption of the green dopant material, (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile (4CzIPN) and harvested all excitons of 4CzIPN. The 3CzPFP:4CzIPN film exhibited high photoluminescence quantum yield of 100%, and the green delayed fluorescence device employing the 3CzPFP host showed high maximum quantum efficiency of 31.2 ± 0.5% at 1% doping after optimization of the device structure.

Inclusive measurement of the photon energy spectrum in b → sγ decays

Abstract: We report a fully inclusive measurement of the flavor changing neutral current decay $b\ensuremath{\rightarrow}s\ensuremath{\gamma}$ in the energy range $1.8\text{ }\mathrm{G}\mathrm{e}\mathrm{V}\ensuremath{\le}{E}_{\ensuremath{\gamma}}^{*}\ensuremath{\le}2.8\text{ }\mathrm{G}\mathrm{e}\mathrm{V}$, covering 95% of the total spectrum. Using $140\text{ }\mathrm{f}{\mathrm{b}}^{\mathrm{\ensuremath{-}}\mathrm{1}}$, we obtain $\mathcal{B}(b\ensuremath{\rightarrow}s\ensuremath{\gamma})=(3.55\ifmmode\pm\else\textpm\fi{}{0.32}_{\ensuremath{-}0.31\ensuremath{-}0.07}^{+0.30+0.11})\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}4}$, where the errors are statistical, systematic, and from theory corrections. We also measure the first and second moments of the photon energy spectrum above $1.8\text{ }\mathrm{G}\mathrm{e}\mathrm{V}$ and obtain $\ensuremath{\langle}{E}_{\ensuremath{\gamma}}\ensuremath{\rangle}=2.292\ifmmode\pm\else\textpm\fi{}0.026\ifmmode\pm\else\textpm\fi{}0.034\text{ }\mathrm{G}\mathrm{e}\mathrm{V}$ and $\ensuremath{\langle}{E}_{\ensuremath{\gamma}}^{2}\ensuremath{\rangle}\ensuremath{-}\ensuremath{\langle}{E}_{\ensuremath{\gamma}}{\ensuremath{\rangle}}^{2}=0.0305\ifmmode\pm\else\textpm\fi{}0.0074\ifmmode\pm\else\textpm\fi{}0.0063\text{ }{\mathrm{G}\mathrm{e}\mathrm{V}}^{2}$, where the errors are statistical and systematic.