Sungkyunkwan University

About: Sungkyunkwan University is a education organization based out in Seoul, South Korea. It is known for research contribution in the topics: Thin film & Graphene. The organization has 28229 authors who have published 56428 publications receiving 1352733 citations. The organization is also known as: 성균관대학교.

Clinical Impact of Intravascular Ultrasound–Guided Chronic Total Occlusion Intervention With Zotarolimus-Eluting Versus Biolimus-Eluting Stent Implantation Randomized Study

Abstract: Background— There have been no randomized studies comparing intravascular ultrasound (IVUS)–guided versus conventional angiography–guided chronic total occlusion (CTO) intervention using new-generation drug-eluting stent Therefore, we conducted a prospective, randomized, multicenter trial designed to test the hypothesis that IVUS-guided CTO intervention is superior to angiography-guided intervention. Methods and Results— After successful guidewire crossing, 402 patients with CTOs were randomized to the IVUS-guided group (n=201) or the angiography-guided group (n=201) and secondarily randomized to Resolute zotarolimus-eluting stents or Nobori biolimus-eluting stents. The primary and secondary end points were cardiac death and a major adverse cardiac event defined as the composite of cardiac death, myocardial infarction, or target-vessel revascularization, respectively. After 12-month follow-up, the rate of cardiac death was not significantly different between the IVUS-guided group (0%) and the angiography-guided group (1.0%; P by log-rank test=0.16). However, major adverse cardiac event rates were significantly lower in the IVUS-guided group than that in the angiography-guided group (2.6% versus 7.1%; P =0.035; hazard ratio, 0.35; 95% confidence interval, 0.13–0.97). Occurrence of the composite of cardiac death or myocardial infarction was significantly lower in the IVUS-guided group (0%) than in the angiography-guided group (2.0%; P =0.045). The rates of target-vessel revascularization were not significantly different between the 2 groups. In the comparison between Resolute zotarolimus-eluting stent and Nobori biolimus-eluting stent, major adverse cardiac event rates were not significantly different (4.0% versus 5.7%; P =0.45). Conclusions— Although IVUS-guided CTO intervention did not significantly reduce cardiac mortality, this randomized study demonstrated that IVUS-guided CTO intervention might improve 12-month major adverse cardiac event rate after new-generation drug-eluting stent implantation when compared with conventional angiography-guided CTO intervention. Clinical Trial Registration— URL: . Unique identifier: [NCT01563952][1]. [1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT01563952&atom=%2Fcirccvint%2F8%2F7%2Fe002592.atom

Target Delivery and Cell Imaging Using Hyaluronic Acid-Functionalized Graphene Quantum Dots

Abstract: This work demonstrates the way to achieve efficient and target specific delivery of a graphene quantum dot (GQD) using hyaluronic acid (HA) (GQD-HA) as a targeting agent. HA has been anchored to a GQD that accepts the fascinating adhesive properties of the catechol moiety, dopamine hydrochloride, conjugated to HA, which was confirmed by X-ray photoelectron spectroscopy. Transmission electron microscopy revealed a particle size of ∼20 nm, and the fluorescence spectra revealed significant fluorescence intensity even after the anchoring of HA. The prepared GQD-HA was applied to CD44 receptor overexpressed tumor-bearing balb/c female mice, and the in vivo biodistribution investigation demonstrated more bright fluorescence from the tumor tissue. In vitro cellular imaging, via a confocal laser scanning microscope, exhibited strong fluorescence from CD44 overexpressed A549 cells. Both in vivo and in vitro results showed the effectiveness of using HA as targeting molecule. The loading and release kinetics of the ...

Fully Packaged Self-Powered Triboelectric Pressure Sensor Using Hemispheres-Array

Abstract: K. Y. Lee, X. Wen, Z. L. Wang School of Material Science and Engineering Georgia Institute of Technology Atlanta, GA 30332-0245, USA E-mail: zlwang@gatech.edu K. Y. Lee, H.-J. Yoon, W. Seung, S.-W. Kim School of Advanced Materials Science and Engineering Sungkyunkwan University (SKKU) Suwon 440-746, Republic of Korea E-mail: kimsw1@skku.edu T. Jiang, Z. L. Wang Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 100083, China S.-W. Kim SKKU Advanced Institute of Nanotechnology (SAINT) Center for Human Interface Nanotechnology (HINT) Sungkyunkwan University Suwon 440-746, Republic of Korea

Experimental constraints on the spin and parity of the Z(4430)

Abstract: We report the results of several studies of the Λc+π+π-X final state in continuum e+e- annihilation data collected by the Belle detector. An analysis of angular distributions in Λc(2880)+→Σc(2455)0, ++π+,- decays strongly favors a Λc(2880)+ spin assignment of 52 over 32 or 12. We find evidence for Λc(2880)+→Σc(2520)0,++π+,- decay and measure the ratio of Λc(2880)+ partial widths Γ(Σc(2520)π)/Γ(Σc(2455)π)=0.225±0. 062±0.025. This value favors the Λc(2880)+ spin-parity assignment of 52+ over 52-. We also report the first observation of Λc(2940) +→Σc(2455)0,++π+,- decay and measure Λc(2880)+ and Λc(2940)+ mass and width parameters. These studies are based on a 553fb-1 data sample collected at or near the Υ(4S) resonance at the KEKB collider. © 2007 The American Physical Society.

Phase III trial of two versus four additional cycles in patients who are nonprogressive after two cycles of platinum-based chemotherapy in non small-cell lung cancer

Abstract: Purpose This trial was conducted to determine the optimal duration of chemotherapy in Korean patients with advanced non–small-cell lung cancer (NSCLC). Patients and Methods Patients with stages IIIB to IV NSCLC who had not progressed after two cycles of chemotherapy were randomly assigned to receive either four (arm A) or two (arm B) more cycles of third-generation, platinum-doublet treatment. Results Of the 452 enrolled patients, 314 were randomly assigned to the groups. One-year survival rates were 59.0% in arm A and 62.4% in arm B, and the difference of 3.4% (95% CI, −8.0 to 4.8) met the predefined criteria for noninferiority. The median time to progression (TTP), however, was 6.2 months (95% CI, 5.7 to 6.7 months) in arm A and 4.6 months (95% CI, 4.4 to 4.8 months) in arm B, the difference of which is statistically significant (P = .001). The frequencies of hematologic and nonhematologic toxicities were similar in the two arms. Conclusion This study confirms the noninferiority of overall survival with...