Institution
Sunnybrook Health Sciences Centre
Healthcare•Toronto, Ontario, Canada•
About: Sunnybrook Health Sciences Centre is a healthcare organization based out in Toronto, Ontario, Canada. It is known for research contribution in the topics: Population & Breast cancer. The organization has 7689 authors who have published 15236 publications receiving 523019 citations. The organization is also known as: Sunnybrook.
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TL;DR: Evidence exists in men for a relationship between OSA and all-cause mortality and a composite CV outcome and an enhanced set of OSA-specific predictors will allow better risk stratification to guide OSA treatment.
184 citations
TL;DR: Tet methylcytosine dioxygenase 2 (TET2) was the most highly expressed Tet enzyme in murine macrophage (MΦ) differentiation, raising the possibility that loss of TET2 function in MΦs may alter the immune environment in the large elderly population with TET1-mutant CHIP and in Tet2-mutants myeloid cancer patients.
184 citations
François-Xavier Lescure1, Hitoshi Honda, Robert A. Fowler2, Jennifer Sloane Lazar +294 more•Institutions (7)
TL;DR: In this article, the authors evaluated the safety and efficacy of sarilumab, an interleukin-6 receptor inhibitor, in patients with severe (requiring supplemental oxygen by nasal cannula or face mask) or critical(requiring greater supplemental oxygen, mechanical ventilation, or extracorporeal support) COVID-19.
184 citations
Cedars-Sinai Medical Center1, Leiden University2, Ruhr University Bochum3, University of Hamburg4, St Thomas' Hospital5, Houston Methodist Hospital6, University of Alabama at Birmingham7, Technische Universität München8, University of Bern9, University of Texas Health Science Center at Houston10, NewYork–Presbyterian Hospital11, Université de Montréal12, Sunnybrook Health Sciences Centre13, Leeds Teaching Hospitals NHS Trust14, Brighton and Sussex University Hospitals NHS Trust15, University of Zurich16, Hospital General Universitario Gregorio Marañón17, Valve Corporation18, Brigham and Women's Hospital19
TL;DR: In this paper, the authors evaluated the outcomes of transcatheter mitral valve replacement in patients with failed mitral bioprosthetic valves (ViV) and annuloplasty rings (valve-in-ring [ViR]).
183 citations
TL;DR: A conical screw profile increases insertion torque, although insertional torque is not a reliable predictor of pull‐out strength in cadaveric bone.
Abstract: Study Design. Insertion torque and pull-out strenghts of conical and cylindrical pedicle screws were compared in human cadaveric vertebral bodies. Objectives. To compare the performance of the conical design with the cylindrical design, and to determine whether insertional torque correlates with pull-out strenght. Summary of Background Data. A tapered pedicle screw design may lessen the likelihood of implant failure. Its effect on thread purchase is not known. Previous studies of cylindrical designs on the relation between insertion torque and pull-out strenght have been conducted in bovine and synthetic bone. Methods. Seventy-eight pedicles were assigned randomly to one of the following pedicle screw: Texas Scottish Rite Hospital (Sofamor-Danek, Memphis, TN), Steffee VSP (Acromed, Cleveland, OH), Diapason (Dimso, Paris, France), AO Schanz (Synthes, Paoli, PA), or Synthes USS (Synthes, Paoli, PA). Pedicle screws were inserted with a torque screwdriver. Each screw was extracted axially from the pedicle at a rate of 1.0 mm/sec until failure using an MTS machine (Bionix 858, Minneapolis, MN). Force data were recorded. Results. The conical design had the highest insertion torque. There were no significant differences in pull-out between any of the screw types. Correlation between insertional torque and pull-out strenght was statistically significant only with the Texas Scottish Rite Hospital and Steffee VSP in L4 and AO Schanz in L5. Conclusions. A conical screw profile increases insertion torque, although insertional torque is not a reliable predictor of pull-out strenght in cadaveric bone. Screw profile (with similar dimensions) has little effect on straight axial pull-out strenghts in cadaveric bone.
183 citations
Authors
Showing all 7765 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Gordon B. Mills | 187 | 1273 | 186451 |
| David A. Bennett | 167 | 1142 | 109844 |
| Bruce R. Rosen | 148 | 684 | 97507 |
| Robert Tibshirani | 147 | 593 | 326580 |
| Steven A. Narod | 134 | 970 | 84638 |
| Peter Palese | 132 | 526 | 57882 |
| Gideon Koren | 129 | 1994 | 81718 |
| John B. Holcomb | 120 | 733 | 53760 |
| Julie A. Schneider | 118 | 492 | 56843 |
| Patrick Maisonneuve | 118 | 582 | 53363 |
| Mitch Dowsett | 114 | 478 | 62453 |
| Ian D. Graham | 113 | 700 | 87848 |
| Peter C. Austin | 112 | 657 | 60156 |
| Sandra E. Black | 104 | 681 | 51755 |
| Michael B. Yaffe | 102 | 379 | 41663 |