Sunnybrook Health Sciences Centre

About: Sunnybrook Health Sciences Centre is a healthcare organization based out in Toronto, Ontario, Canada. It is known for research contribution in the topics: Population & Breast cancer. The organization has 7689 authors who have published 15236 publications receiving 523019 citations. The organization is also known as: Sunnybrook.

Chromosomal toxin-antitoxin loci can diminish large-scale genome reductions in the absence of selection.

Abstract: Superintegrons (SIs) are chromosomal genetic elements containing assemblies of genes, each flanked by a recombination sequence (attC site) targeted by the integron integrase. SIs may contain hundreds of attC sites and intrinsic instability is anticipated; yet SIs are remarkably stable. This implies that either selective pressure maintains the genes or mechanisms exist which favour their persistence in the absence of selection. Toxin/antitoxin (TA) systems encode a stable toxin and a specific, unstable antitoxin. Once activated, the continued synthesis of the unstable antitoxin is necessary for cell survival. A bioinformatic search of accessible microbial genomes for SIs and TA systems revealed that large SIs harboured TA gene cassettes while smaller SIs did not. We demonstrated the function of TA loci in different genomic contexts where large-scale deletions can occur; in SIs and in a 165 kb dispensable region of the Escherichia coli genome. When devoid of TA loci, large-scale genome loss was evident in both environments. The inclusion of two TA loci, relBE1 and parDE1, which we identified in the Vibrio vulnificus SI rendered these environments refractory to gene loss. Thus, chromosomal TA loci can stabilize massive SI arrays and limit the extensive gene loss that is a hallmark of reductive evolution.

Electrical breakdown in low pressure gases

Abstract: The paper presents the results of investigation of the electrical breakdown in low pressure gases when the secondary electrons released from the cathode play the dominant role in the initiation of electrical breakdown. The secondary electrons are created by the charged and neutral species formed during the previous breakdown and discharge as well as by γ-rays. Electrical breakdown investigations are based on the measurements of electrical breakdown voltage and electrical breakdown time delay for gas-filled tubes with spherical electrodes with diameters much larger than an interelectrode distance. Stochastic nature of both the breakdown voltage and time delay are discussed and their distributions based on experimental data are shown. The methods for the determination of static breakdown voltage are also analysed. The influence of different parameters (overvoltage, cathode material and its surface purity, gas pressure, glow current, etc) on time delay are studied. A special attention is paid to the memory effect in various gases that depends on the positive ion recombination times, catalytic recombination times in the case of nitrogen and hydrogen, as well as metastable states deexcitation times in noble gases. The analysis of this effect is done by memory curves on the basis of which the presence of long-lived neutral active states can be followed to their very low concentrations when cosmic and environment radiation play the dominant role in electrical breakdown initiation.

A report on older-age bipolar disorder from the International Society for Bipolar Disorders Task Force

Abstract: Objectives: In the coming generation, older adults with bipolar disorder (BD) will increase in absolute numbers as well as proportion of the general population. This is the first report of the International Society for Bipolar Disorder (ISBD) Task Force on Older-Age Bipolar Disorder (OABD). Methods: This task force report addresses the unique aspects of OABD including epidemiology and clinical features, neuropathology and biomarkers, physical health, cognition, and care approaches. Results: The report describes an expert consensus summary on OABD that is intended to advance the care of patients, and shed light on issues of relevance to BD research across the lifespan. Although there is still a dearth of research and health efforts focused on older adults with BD, emerging data have brought some answers, innovative questions, and novel perspectives related to the notion of late onset, medical comorbidity, and the vexing issue of cognitive impairment and decline. Conclusions: Improving our understanding of the biological, clinical, and social underpinnings relevant to OABD is an indispensable step in building a complete map of BD across the lifespan. © 2015 John Wiley

Six-Month Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery

Abstract: Background We reported previously that, in patients undergoing cardiac surgery who were at moderate-to-high risk for death, a restrictive transfusion strategy was noninferior to a liberal strategy with respect to the composite outcome of death from any cause, myocardial infarction, stroke, or new-onset renal failure with dialysis by hospital discharge or 28 days after surgery, whichever came first. We now report the clinical outcomes at 6 months after surgery. Methods We randomly assigned 5243 adults undergoing cardiac surgery to a restrictive red-cell transfusion strategy (transfusion if the hemoglobin concentration was <7.5 g per deciliter intraoperatively or postoperatively) or a liberal red-cell transfusion strategy (transfusion if the hemoglobin concentration was <9.5 g per deciliter intraoperatively or postoperatively when the patient was in the intensive care unit [ICU] or was <8.5 g per deciliter when the patient was in the non-ICU ward). The primary composite outcome was death from any c...