Sunnybrook Health Sciences Centre

About: Sunnybrook Health Sciences Centre is a healthcare organization based out in Toronto, Ontario, Canada. It is known for research contribution in the topics: Population & Breast cancer. The organization has 7689 authors who have published 15236 publications receiving 523019 citations. The organization is also known as: Sunnybrook.

Targeted insertion of Cre recombinase into the TNAP gene: excision in primordial germ cells.

Abstract: system are a powerful approach to study thefunction of genes in particular cell lineages and forwhich generalized null mutations result in early lethalphenotypes (Lobe and Nagy, 1998). Here we report thecreation of a primarily PGC (primordial germ cell) spe-cific Cre recombinase transgenic line, designated TNAP-Cre. In this strain, the Cre recombinase has beenknocked into the locus of the TNAP (Tissue Non-SpecificAlkaline Phosphatase) gene.The structure of the TNAP-Cre targeting construct isdepicted in Figure 1a. After electroporation into R1 ES(Nagy

Examining the potential relationship between multidisciplinary cancer care and patient survival: an international literature review.

Abstract: Background and Objectives The aim of this review is to examine the relationship between multidisciplinary cancer care and patient survival. Methods A literature review was undertaken between January 1950 and September 2009. Included studies described multidisciplinary cancer care and its relation to patient survival. Multidisciplinary care was defined as involvement of a team of clinical and allied specialists whose intent is individualized patient management. Studies were critically appraised for internal and external validity. All study designs were included. Results Twenty-one studies met eligibility criteria for this review, including two systematic reviews, one abstract, and 18 original studies. Pooling of results was not possible due to heterogeneity of patient populations, disease sites, measured outcomes, and follow-up periods. Twelve studies (one prospective and six retrospective cohort studies, five before–after series) reported statistically significant association between multidisciplinary care and patient survival. Conclusions Due to methodological limitations, this review is unable to assert a causal relationship between multidisciplinary care and patient survival. In order to better evaluate this relationship, the oncology community must first accept a common definition of multidisciplinary care. Future efforts can then elucidate which aspects of multidisciplinary care impact survival, with consideration of confounding patient and tumour factors. J. Surg. Oncol. 2010;102:125–134. © 2010 Wiley-Liss, Inc.

Patients' Health-care Decision Making: A Framework for Descriptive and Experimental Investigations

Abstract: here and in Canada; this is my first opportunity to pull these aspects together into what I hope will be a reasonably coherent pictures I am particularly indebted to my friend and colleague, Annette O’Connor, whose creativity and insight have contributed to the formulation and articulation of this framework in significant ways’:¡,4 I present it today because it may be helpful to others who are currently involved in or are initiating studies of patients’ decision making.

Three-dimensional facial anthropometry using a laser surface scanner : Validation of the technique

Abstract: Three-dimensional measurement and characterization of facial surface anatomy are fundamental to the objective analysis of facial deformity. However, existing clinical tools are inadequate. Recent innovations in laser scanning technology provide a potentially useful technique for accurate three-dimensional documentation of the face. The purpose of this study is to evaluate the reliability of interactive anthropometric landmark localization based on digitized three-dimensional facial images and to identify sources of error associated with the technique. Three-dimensional surface data were acquired using a commercially available laser scanning device (Cyberware 3030RGB digitizer), and all subsequent anthropometric analyses were performed interactively on the computer monitor. Four experimental conditions were studied, with 10 observations for each condition. A stable anthropomorphic model with prelabeled anatomic landmarks was scanned repeatedly under varying conditions of head inclination and position within the scanning gantry to determine the effect of these variables on the reliability of the technique. The scanning protocol was then repeated with the labels removed to evaluate the reliability of interactive localization of anthropometric landmarks on a digitized three-dimensional image. Optimal results were obtained with the head positioned in the center of the scanning gantry and with the Frankfort plane elevated 10 degrees from the horizontal. Under these circumstances, all 22 labeled landmarks were visualized and the variance in landmark localization was less than 0.6 mm in the x (horizontal), y (vertical), and z (depth) dimensions. Varying head position or inclination caused significant degradation of the digitized image. The variance of interactive landmark localization was analyzed in three dimensions. The reliability and the spatial orientation of variability were determined for each anthropometric point. These findings have direct implications for the clinical adaptation of this diagnostic tool for quantitative evaluation of facial surface anatomy.