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Institution

Sunnybrook Health Sciences Centre

HealthcareToronto, Ontario, Canada
About: Sunnybrook Health Sciences Centre is a healthcare organization based out in Toronto, Ontario, Canada. It is known for research contribution in the topics: Population & Breast cancer. The organization has 7689 authors who have published 15236 publications receiving 523019 citations. The organization is also known as: Sunnybrook.


Papers
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Journal ArticleDOI
TL;DR: The authors demonstrate that spoiler gradients are the most effective technique for artifact suppression but that they render ineffective radio‐frequency phase schemes such as the Meiboom‐Gill modification to the Carr‐Purcell sequence to compensate experimental imperfections.
Abstract: Many studies have investigated the use of magnetic resonance relaxation times for tissue characterization. A number have been performed in vivo with clinical whole-body imagers. Unfortunately, the results have yet to establish the role of quantitative tissue relaxation time measurements in clinical diagnosis. One of the major problems is that the techniques used in many of these studies are error prone, making the results inconclusive. In the present study, the problems associated with clinical T2 measurements were systematically evaluated in an attempt to obtain reliable in vivo quantitation. The authors demonstrate that spoiler gradients are the most effective technique for artifact suppression but that they render ineffective radio-frequency phase schemes such as the Meiboom-Gill modification to the Carr-Purcell sequence to compensate experimental imperfections. The present study results in a more reliable multi-echo sequence for T2 measurement. Preliminary clinical results in brain and cervix demonstrate the performance of the new technique.

397 citations

Journal ArticleDOI
TL;DR: Exome sequencing data provide more evidence supporting the role of aberrant RNA processing in motor neuron degeneration in ALS kindreds and observed MATR3 pathology in ALS-affected spinal cords with and withoutMATR3 mutations.
Abstract: MATR3 is an RNA- and DNA-binding protein that interacts with TDP-43, a disease protein linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Using exome sequencing, we identified mutations in MATR3 in ALS kindreds. We also observed MATR3 pathology in ALS-affected spinal cords with and without MATR3 mutations. Our data provide more evidence supporting the role of aberrant RNA processing in motor neuron degeneration.

396 citations

Journal ArticleDOI
TL;DR: The evidence-based recommendations for the prevention and treatment of hypertension in adults for 2010 are updated and treatment thresholds and targets should be predicated on the patient's global atherosclerotic risk, target organ damage and comorbid conditions.

395 citations

Journal ArticleDOI
24 Apr 1997-Nature
TL;DR: The results indicate that calreticulin is an essential modulator both of integrin adhesive functions and integrin-initiated signalling, but that it may not play a significant role in the storage of luminal calcium.
Abstract: Integrins are important mediators of cell adhesion to extracellular ligands and can transduce biochemical signals both into and out of cells1,2. The cytoplasmic domains of integrins interact with several structural and signalling proteins and consequently participate in the regulation of cell shape, motility, growth and differentiation3. It has been shown that calreticulin associates with the cytoplasmic domains of integrin α-subunits and that this interaction can influence integrin-mediated cell adhesion to extracellular matrix4,5. We have now developed calreticulin-deficient embryonic stem (ES) cells and isolated embryonic fibro-blasts from calreticulin mutant mice. We find that in both cell types integrin-mediated adhesion is severely impaired, although integrin expression is unaltered. Expression of recombinant calreticulin in double knockout ES cells by complementary DNA transfection rescued integrin-mediated adhesion. In wild-type cells, engagement of surface integrins induced a transient elevation in cytosolic calcium concentration owing to influx of extracellular calcium. This calcium transient was absent in calreticulin-deficient cells. In contrast, the amount of calcium in endomembrane stores, which is sensitive to both inositol 1,4,5-trisphosphate and thapsigargin, was indistinguishable in the two cell types. Our results indicate that calreticulin is an essential modulator both of integrin adhesive functions and integrin-initiated signalling, but that it may not play a significant role in the storage of luminal calcium.

394 citations

Journal ArticleDOI
TL;DR: Because of the complexity of injuries that most often result in acute pelvic fractures, they should be considered in the context of polytrauma management, rather than in isolation.
Abstract: Acute pelvic fractures are potentially lethal, even with modern techniques of poly-trauma care. The appropriate treatment of such fractures is dependent on a thorough understanding of the anatomic features of the pelvic region and the biomechanical basis of the various types of lesions. Although the anterior structures, the symphysis pubis and the pubic rami, contribute approximately 40% to the stiffness of the pelvis, clinical and biomechanical studies have shown that the posterior sacroiliac complex is more important to pelvic-ring stability. Therefore, the classification of pelvic fractures is based on the stability of the posterior lesion. In type A fractures, the pelvic ring is stable. The partially stable type B lesions, such as "open-book" and "bucket-handle" fractures, are caused by external- and internal-rotation forces, respectively. In type C injuries, there is complete disruption of the posterior sacroiliac complex. These unstable fractures are almost always caused by high-energy severe trauma associated with motor vehicle accidents, falls from a height, or crushing injuries. Type A and type B fractures make up 70% to 80% of all pelvic injuries. Because of the complexity of injuries that most often result in acute pelvic fractures, they should be considered in the context of polytrauma management, rather than in isolation. Any classification system must therefore be seen only as a general guide to treatment. The management of each patient requires careful, individualized decision making.

393 citations


Authors

Showing all 7765 results

NameH-indexPapersCitations
Gordon B. Mills1871273186451
David A. Bennett1671142109844
Bruce R. Rosen14868497507
Robert Tibshirani147593326580
Steven A. Narod13497084638
Peter Palese13252657882
Gideon Koren129199481718
John B. Holcomb12073353760
Julie A. Schneider11849256843
Patrick Maisonneuve11858253363
Mitch Dowsett11447862453
Ian D. Graham11370087848
Peter C. Austin11265760156
Sandra E. Black10468151755
Michael B. Yaffe10237941663
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202324
2022103
20211,627
20201,385
20191,171
20181,044