Institution
Sunnybrook Health Sciences Centre
Healthcare•Toronto, Ontario, Canada•
About: Sunnybrook Health Sciences Centre is a healthcare organization based out in Toronto, Ontario, Canada. It is known for research contribution in the topics: Population & Breast cancer. The organization has 7689 authors who have published 15236 publications receiving 523019 citations. The organization is also known as: Sunnybrook.
Papers published on a yearly basis
Papers
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TL;DR: The authors demonstrate that spoiler gradients are the most effective technique for artifact suppression but that they render ineffective radio‐frequency phase schemes such as the Meiboom‐Gill modification to the Carr‐Purcell sequence to compensate experimental imperfections.
Abstract: Many studies have investigated the use of magnetic resonance relaxation times for tissue characterization. A number have been performed in vivo with clinical whole-body imagers. Unfortunately, the results have yet to establish the role of quantitative tissue relaxation time measurements in clinical diagnosis. One of the major problems is that the techniques used in many of these studies are error prone, making the results inconclusive. In the present study, the problems associated with clinical T2 measurements were systematically evaluated in an attempt to obtain reliable in vivo quantitation. The authors demonstrate that spoiler gradients are the most effective technique for artifact suppression but that they render ineffective radio-frequency phase schemes such as the Meiboom-Gill modification to the Carr-Purcell sequence to compensate experimental imperfections. The present study results in a more reliable multi-echo sequence for T2 measurement. Preliminary clinical results in brain and cervix demonstrate the performance of the new technique.
397 citations
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National Institutes of Health1, Cleveland Clinic2, Barrow Neurological Institute3, Henry Ford Hospital4, St. Jude Children's Research Hospital5, University College London6, Queen Mary University of London7, Washington University in St. Louis8, Cedars-Sinai Medical Center9, University of Toronto10, Sunnybrook Health Sciences Centre11, Tel Aviv Sourasky Medical Center12, University of Cagliari13, University of Turin14, Johns Hopkins University15, University of Würzburg16, The Catholic University of America17
TL;DR: Exome sequencing data provide more evidence supporting the role of aberrant RNA processing in motor neuron degeneration in ALS kindreds and observed MATR3 pathology in ALS-affected spinal cords with and withoutMATR3 mutations.
Abstract: MATR3 is an RNA- and DNA-binding protein that interacts with TDP-43, a disease protein linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Using exome sequencing, we identified mutations in MATR3 in ALS kindreds. We also observed MATR3 pathology in ALS-affected spinal cords with and without MATR3 mutations. Our data provide more evidence supporting the role of aberrant RNA processing in motor neuron degeneration.
396 citations
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University of Western Ontario1, University of British Columbia2, University of Calgary3, Ottawa Hospital Research Institute4, University of Alberta5, Canadian Stroke Network6, Jewish General Hospital7, University of Ottawa8, Université de Montréal9, Laval University10, University Health Network11, Queen Elizabeth II Health Sciences Centre12, McGill University13, Concordia University14, Lawson Health Research Institute15, Université de Sherbrooke16, University of Saskatchewan17, Hôpital Maisonneuve-Rosemont18, University of Toronto19, St. Michael's Hospital20, Toronto Western Hospital21, University of Manitoba22, Sunnybrook Health Sciences Centre23
TL;DR: The evidence-based recommendations for the prevention and treatment of hypertension in adults for 2010 are updated and treatment thresholds and targets should be predicated on the patient's global atherosclerotic risk, target organ damage and comorbid conditions.
395 citations
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TL;DR: The results indicate that calreticulin is an essential modulator both of integrin adhesive functions and integrin-initiated signalling, but that it may not play a significant role in the storage of luminal calcium.
Abstract: Integrins are important mediators of cell adhesion to extracellular ligands and can transduce biochemical signals both into and out of cells1,2. The cytoplasmic domains of integrins interact with several structural and signalling proteins and consequently participate in the regulation of cell shape, motility, growth and differentiation3. It has been shown that calreticulin associates with the cytoplasmic domains of integrin α-subunits and that this interaction can influence integrin-mediated cell adhesion to extracellular matrix4,5. We have now developed calreticulin-deficient embryonic stem (ES) cells and isolated embryonic fibro-blasts from calreticulin mutant mice. We find that in both cell types integrin-mediated adhesion is severely impaired, although integrin expression is unaltered. Expression of recombinant calreticulin in double knockout ES cells by complementary DNA transfection rescued integrin-mediated adhesion. In wild-type cells, engagement of surface integrins induced a transient elevation in cytosolic calcium concentration owing to influx of extracellular calcium. This calcium transient was absent in calreticulin-deficient cells. In contrast, the amount of calcium in endomembrane stores, which is sensitive to both inositol 1,4,5-trisphosphate and thapsigargin, was indistinguishable in the two cell types. Our results indicate that calreticulin is an essential modulator both of integrin adhesive functions and integrin-initiated signalling, but that it may not play a significant role in the storage of luminal calcium.
394 citations
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TL;DR: Because of the complexity of injuries that most often result in acute pelvic fractures, they should be considered in the context of polytrauma management, rather than in isolation.
Abstract: Acute pelvic fractures are potentially lethal, even with modern techniques of poly-trauma care. The appropriate treatment of such fractures is dependent on a thorough understanding of the anatomic features of the pelvic region and the biomechanical basis of the various types of lesions. Although the anterior structures, the symphysis pubis and the pubic rami, contribute approximately 40% to the stiffness of the pelvis, clinical and biomechanical studies have shown that the posterior sacroiliac complex is more important to pelvic-ring stability. Therefore, the classification of pelvic fractures is based on the stability of the posterior lesion. In type A fractures, the pelvic ring is stable. The partially stable type B lesions, such as "open-book" and "bucket-handle" fractures, are caused by external- and internal-rotation forces, respectively. In type C injuries, there is complete disruption of the posterior sacroiliac complex. These unstable fractures are almost always caused by high-energy severe trauma associated with motor vehicle accidents, falls from a height, or crushing injuries. Type A and type B fractures make up 70% to 80% of all pelvic injuries. Because of the complexity of injuries that most often result in acute pelvic fractures, they should be considered in the context of polytrauma management, rather than in isolation. Any classification system must therefore be seen only as a general guide to treatment. The management of each patient requires careful, individualized decision making.
393 citations
Authors
Showing all 7765 results
Name | H-index | Papers | Citations |
---|---|---|---|
Gordon B. Mills | 187 | 1273 | 186451 |
David A. Bennett | 167 | 1142 | 109844 |
Bruce R. Rosen | 148 | 684 | 97507 |
Robert Tibshirani | 147 | 593 | 326580 |
Steven A. Narod | 134 | 970 | 84638 |
Peter Palese | 132 | 526 | 57882 |
Gideon Koren | 129 | 1994 | 81718 |
John B. Holcomb | 120 | 733 | 53760 |
Julie A. Schneider | 118 | 492 | 56843 |
Patrick Maisonneuve | 118 | 582 | 53363 |
Mitch Dowsett | 114 | 478 | 62453 |
Ian D. Graham | 113 | 700 | 87848 |
Peter C. Austin | 112 | 657 | 60156 |
Sandra E. Black | 104 | 681 | 51755 |
Michael B. Yaffe | 102 | 379 | 41663 |