Swedish Defence Research Agency

About: Swedish Defence Research Agency is a government organization based out in Stockholm, Sweden. It is known for research contribution in the topics: Radar & Synthetic aperture radar. The organization has 1413 authors who have published 2731 publications receiving 56083 citations. The organization is also known as: Totalförsvarets forskningsinstitut.

Target classification in perimeter protection with a micro-Doppler radar

Abstract: In security surveillance at the perimeter of critical infrastructure, such as airports and power plants, approaching objects have to be detected and classified. Especially important is to distinguish between humans, animals and vehicles. In this paper, micro-Doppler data (from movement of internal parts of the target) have been collected with a small radar of a low-complexity and cost-effective type. From time-velocity diagrams of the data, some physical features have been extracted and used in a support vector machine classifier to distinguish between the classes "human", "animal" and "man-made object". Both the type of radar and the classes are suitable for perimeter protection. The classification result are rather good, 77% correct classification. Particularly interesting is the surprisingly good ability to distinguish between humans and animals. This also indicates that we can choose to have limitations in the radar and still solve the classification task.

CBP binding outside of promoters and enhancers in Drosophila melanogaster

Abstract: Background: CREB-binding protein (CBP, also known as nejire) is a transcriptional co-activator that is conserved in metazoans. CBP plays an important role in embryonic development and cell differentiation and mutations in CBP can lead to various diseases in humans. In addition, CBP and the related p300 protein have successfully been used to predict enhancers in both humans and flies when they occur with monomethylation of histone H3 on lysine 4 (H3K4me1). Results: Here, we compare CBP chromatin immunoprecipitation sequencing data from Drosophila S2 cells with modENCODE data and show that CBP is bound at genomic sites with a wide range of functions. As expected, we find that CBP is bound at active promoters and enhancers. In addition, we find that the strongest CBP sites in the genome are found at Polycomb response elements embedded in histone H3 lysine 27 trimethylated (H3K27me3) chromatin, where they correlate with binding of the Pho repressive complex. Interestingly, we find that CBP also binds to most insulators in the genome. At a subset of these, CBP may regulate insulating activity, measured as the ability to prevent repressive H3K27 methylation from spreading into adjacent chromatin. Conclusions: We conclude that CBP could be involved in a much wider range of functions than has previously been appreciated, including Polycomb repression and insulator activity. In addition, we discuss the possibility that a common role for CBP at all functional elements may be to regulate interactions between distant chromosomal regions and speculate that CBP is controlling higher order chromatin organization.