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Institution

Swedish University of Agricultural Sciences

EducationUppsala, Sweden
About: Swedish University of Agricultural Sciences is a education organization based out in Uppsala, Sweden. It is known for research contribution in the topics: Population & Soil water. The organization has 13510 authors who have published 35241 publications receiving 1414458 citations. The organization is also known as: Sveriges Lantbruksuniversitet & SLU.


Papers
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Journal ArticleDOI
TL;DR: A correlation between decreasing mucus barrier and increasing clinical symptoms during onset of colitis is demonstrated and the ability of bacteria to regulate the thickness of the colonic mucus was demonstrated.
Abstract: The colonic mucus layer serves as an important barrier and prevents colonic bacteria from invading the mucosa and cause inflammation. The regulation of colonic mucus secretion is poorly understood. The aim of this study was to investigate the role of the mucus barrier in induction of colitis. Furthermore, regulation of mucus secretion by luminal bacterial products was studied. The colon of anesthetized Muc2−/−, Muc1−/−, wild-type (wt), and germ-free mice was exteriorized, the mucosal surface was visualized, and mucus thickness was measured with micropipettes. Colitis was induced by DSS (dextran sodium sulfate, 3%, in drinking water), and disease activity index (DAI) was assessed daily. The colonic mucosa of germ-free and conventionally housed mice was exposed to the bacterial products LPS (lipopolysaccharide) and PGN (peptidoglycan). After DSS induction of colitis, the thickness of the firmly adherent mucus layer was significantly thinner after 5 days and onward, which paralleled the increment of DAI. Muc2−/− mice, which lacked firmly adherent mucus, were predisposed to colitis, whereas Muc1−/− mice were protected with significantly lower DAI by DSS compared with wt mice. The mucus barrier increased in Muc1−/− mice in response to DSS, whereas significantly fewer T cells were recruited to the inflamed colon. Mice housed under germ-free conditions had an extremely thin adherent colonic mucus layer, but when exposed to bacterial products (PGN or LPS) the thickness of the adherent mucus layer was quickly restored to levels observed in conventionally housed mice. This study demonstrates a correlation between decreasing mucus barrier and increasing clinical symptoms during onset of colitis. Mice lacking colonic mucus (Muc2−/−) were hypersensitive to DSS-induced colitis, whereas Muc1−/− were protected, probably through the ability to increase the mucus barrier but also by decreased T cell recruitment to the afflicted site. Furthermore, the ability of bacteria to regulate the thickness of the colonic mucus was demonstrated.

318 citations

Journal ArticleDOI
TL;DR: In this paper, the X-ray structure of the quaternary complex of ribulose 1,5-bisphosphate carboxylase/oxygenase from spinach with CO2, Mg2+ and a reaction-intermediate analogue (CABP) has been determined and refined at 2·4 A resolution.

318 citations

Journal ArticleDOI
TL;DR: A method to screen lactobacilli for production of unique antimicrobial substances and the discovery of reuterin is described, capable of inhibiting growth of species representing all bacterial genera tested thus far.
Abstract: Lactobacillus reuteri resides in the gastrointestinal tract of humans, swine, poultry and other animals. Resting cells of this species convert glycerol into a potent, broad-spectrum antimicrobial substance termed reuterin. Reuterin is a low molecular weight, neutral, water soluble compound, capable of inhibiting growth of species representing all bacterial genera tested thus far, including: Escherichia, Salmonella, Shigella, Proteus, Pseudomonas, Clostridium and Staphylococcus. Also affected, but to a lesser degree, are lactic acid bacteria belonging to the genera Streptococcus, Pediococcus, Leuconostoc, and Lactobacillus. In this report we describe a method to screen lactobacilli for production of unique antimicrobial substances and the discovery of reuterin.

318 citations

Journal ArticleDOI
TL;DR: Seed maturation is an important phase of seed development during which embryo growth ceases, storage products accumulate, the protective tegument differentiates and tolerance to desiccation develops, leading to seed dormancy.

318 citations

Journal ArticleDOI
TL;DR: It is found that both climate change and alien species will ultimately lead to the creation of novel communities, and certain interactions may no longer occur while there will also be potential for the emergence of new relationships.
Abstract: Global change may substantially affect biodiversity and ecosystem functioning but little is known about its effects on essential biotic interactions. Since different environmental drivers rarely act in isolation it is important to consider interactive effects. Here, we focus on how two key drivers of anthropogenic environmental change, climate change and the introduction of alien species, affect plant-pollinator interactions. Based on a literature survey we identify climatically sensitive aspects of species interactions, assess potential effects of climate change on these mechanisms, and derive hypotheses that may form the basis of future research. We find that both climate change and alien species will ultimately lead to the creation of novel communities. In these communities certain interactions may no longer occur while there will also be potential for the emergence of new relationships. Alien species can both partly compensate for the often negative effects of climate change but also amplify them in some cases. Since potential positive effects are often restricted to generalist interactions among species, climate change and alien species in combination can result in significant threats to more specialist interactions involving native species.

317 citations


Authors

Showing all 13653 results

NameH-indexPapersCitations
Svante Pääbo14740784489
Lars Klareskog13169763281
Stephen Hillier129113883831
Carol V. Robinson12367051896
Jun Yu121117481186
Peter J. Anderson12096663635
David E. Clapham11938258360
Angela M. Gronenborn11356844800
David A. Wardle11040970547
Agneta Oskarsson10676640524
Jack S. Remington10348138006
Hans Ellegren10234939437
Per A. Peterson10235635788
Malcolm J. Bennett9943937207
Gunnar E. Carlsson9846632638
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023116
2022252
20212,311
20201,957
20191,787
20181,624