Education•Medina, Saudi Arabia•
About: Taibah University is a education organization based out in Medina, Saudi Arabia. It is known for research contribution in the topics: Nonlinear system & Population. The organization has 2947 authors who have published 6795 publications receiving 77065 citations.
Papers published on a yearly basis
TL;DR: A review on the preparation of activated carbon from agricultural waste material is presented in this article, where various physical and chemical processes for the activation of the agricultural residues and their effects on the textural properties such as surface area and pore volume are discussed.
Abstract: A review on the preparation of the activated carbon from agricultural waste material is presented. The physical properties such as proximate and ultimate analysis of agricultural waste material were reviewed. The chemical compositions such as cellulose, hemicelluloses and lignin contents were also discussed. The effects of various parameters on the preparation such as carbonization and activation temperature, time, types of activating agents and impregnation ratio were reviewed. Various physical and chemical processes for the activation of the agricultural residues and their effects on the textural properties such as surface area and pore volume were discussed. The low cost, renewable and relatively less expensive of the agricultural waste were found to be efficiently being converted into wealth. The uses of activated carbon derived from agricultural residues in many fields were evidently proven in the review. The reaction kinetic modeling on the pyrolysis and activation of agricultural wastes were also reviewed.
TL;DR: The Ki67 PI is significantly higher in Saudi BC patients comparing with the reported literature, and was highest in the HER-2 and luminal-B molecular subtypes.
Abstract: Objectives: To evaluate Ki67 immunoexpression pattern in Saudi breast cancer (BC) patients and investigate any possible predictive or prognostic value for Ki67. Methods: This is a retrospective study designed to quantitatively assess the Ki67 proliferative index (PI) in retrieved paraffin blocks of 115 Saudi BC patients diagnosed between January 2005 and March 2015 at the Department of Pathology, King Fahd Hospital, Al Madinah Al Munawarah, Kingdom of Saudi Arabia. The Ki67 PI was correlated with individual and combined immunoprofile data of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2/neu) with their clinicopathological parameters. Results: Ki67 immunoreactivity was highly expressed (greater than 25% of the tumor cells were positive) in 85 (73.9%) patients. The Ki67 PI was significantly associated with poor prognostic clinicopathological parameters including old age ( p less than 0.02), high tumor grade ( p less than 0.01), lymph node metastasis ( p less than 0.001), and Her-2/neu positivity ( p less than 0.009). However, the association with ER positivity, PR positivity, tumor size, and lymphovascular invasion were not statistically significant. The Ki67 PI was significantly associated with BC molecular subtypes that were Her2/neu positive (luminal B and HER-2) subtypes compared with the Her2/neu negative (luminal A) subtype ( p less than 0.04). Conclusion: The Ki67 PI is significantly higher in Saudi BC patients comparing with the reported literature. Ki67 PI was highest in the HER-2 and luminal-B molecular subtypes. Along with other prognostic indicators, Ki67 PI may be useful in predicting prognosis and management of Saudi BC patients. Saudi Med J 2016; Vol. 37 (2): 137-141 doi: 10.15537/smj.2016.2.12285 How to cite this article: Elkablawy MA, Albasri AM, Mohammed RA, Hussainy AS, Nouh MM, Alhujaily AS. Ki67 expression in breast cancer . Correlation with prognostic markers and clinicopathological parameters in Saudi patients . Saudi Med J 2016; 37: 137-41.
TL;DR: In this article, the authors used hot water olive leaf extracts (OLE) as reducing and stabilizing agent for antibacterial activity against drug resistant bacterial isolates and found that the AgNPs at 0.03-0.07 mg/ml concentration significantly inhibited bacterial growth against multi-drug resistant Staphylococcus aureus (S. aUREus ), Pseudomonas aeruginosa (P. aerUGinosa ), and Escherichia coli ( E. coli ).
Abstract: The silver nanoparticles (AgNPs) synthesized using hot water olive leaf extracts (OLE) as reducing and stabilizing agent are reported and evaluated for antibacterial activity against drug resistant bacterial isolates. The effect of extract concentration, contact time, pH and temperature on the reaction rate and the shape of the Ag nanoparticles are investigated. The data revealed that the rate of formation of the nanosilver increased significantly in the basic medium with increasing temperature. The nature of AgNPs synthesized was analyzed by UV–vis spectroscopy, X-ray diffraction, scanning electron microscopy and thermal gravimetric analysis (TGA). The silver nanoparticles were with an average size of 20–25 nm and mostly spherical. The antibacterial potential of synthesized AgNPs was compared with that of aqueous OLE by well diffusion method. The AgNPs at 0.03–0.07 mg/ml concentration significantly inhibited bacterial growth against multi drug resistant Staphylococcus aureus ( S. aureus ), Pseudomonas aeruginosa ( P. aeruginosa ) and Escherichia coli ( E. coli ). This study revealed that the aqueous olive leaf extract has no effect at the concentrations used for preparation of the Ag nanoparticles. Thus AgNPs showed broad spectrum antibacterial activity at lower concentration and may be a good alternative therapeutic approach in future.
TL;DR: Considering mechanical and physical properties similar to bone, PEEK can be used in many areas of dentistry and further modifications and improving the material properties may increase its applications in clinical dentistry.
Abstract: Purpose Polyetheretherketone (PEEK) is a polymer that has many potential uses in dentistry. The aim of this review was to summarize the outcome of research conducted on the material for dental applications. In addition, future prospects of PEEK in the field of clinical dentistry have been highlighted. Study selection An electronic search was carried out via the PubMed (Medline) database using keywords ‘polyetheretherketone’, ‘dental’ and ‘dentistry’ in combination. Original research papers published in English language in last fifteen year were considered. The studies relevant to our review were critically analyzed and summarized. Results PEEK has been explored for a number of applications for clinical dentistry. For example, PEEK dental implants have exhibited lesser stress shielding compared to titanium dental implants due to closer match of mechanical properties of PEEK and bone. PEEK is a promising material for a number of removable and fixed prosthesis. Furthermore, recent studies have focused improving the bioactivity of PEEK implants at the nanoscale. Conclusion Considering mechanical and physical properties similar to bone, PEEK can be used in many areas of dentistry. Improving the bioactivity of PEEK dental implants without compromising their mechanical properties is a major challenge. Further modifications and improving the material properties may increase its applications in clinical dentistry.
TL;DR: A prominent pro‐inflammatory Th1 and Th17 response was clearly seen in patients with MERS‐CoV infection, with markedly increased concentrations of IFN‐&ggr;, TNF‐&agR;, IL‐15 and IL‐17 compared to controls.
Abstract: The Middle East respiratory syndrome coronavirus (MERS-CoV) has been recognized as a highly pathogenic virus to humans that infects the respiratory tract and is associated with high morbidity and mortality. Studies in animal models suggest that MERS-CoV infection induces a strong inflammatory response, which may be related to the severity of disease. Data showing the cytokine profiles in humans during the acute phase of MERS-CoV infection are limited. In this study, we have analyzed the profile of cytokine responses in plasma samples from patients with confirmed MERS-CoV infections (n = 7) compared to healthy controls (n = 13). The cytokine profiles, including T helper (Th) 1, Th2 and Th17 responses, were analyzed using cytometric bead array (CBA). A prominent pro-inflammatory Th1 and Th17 response was clearly seen in patients with MERS-CoV infection, with markedly increased concentrations of IFN-γ, TNF-α, IL-15 and IL-17 compared to controls. IL-12 expression levels showed no difference between patients with MERS-CoV infection and the healthy controls despite the significantly increased levels of IFN-α2 and IFN-γ (P .05). Our results demonstrate a marked pro-inflammatory cytokine response during the acute phase of MERS-CoV infection in humans.
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|Aly R. Seadawy||62||360||9884|
|Nordin H. Lajis||40||219||5844|
|Ahmed M. Abu-Dief||36||99||3469|
|Bader S. Ghanem||34||75||6977|
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