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Showing papers by "Tallinn University of Technology published in 1996"


Journal ArticleDOI
TL;DR: A close relationship between inhibition of respiration of irradiated cells and their ability to survive is indicated and it is not clear from the present results whether LEV may perturb energy metabolism in V79 cells since LEV alone did not reduce the energy charge or the NADH/NAD+ ratio.
Abstract: The ability of endogenously synthesized protoporphyrin IX (PpIX) to damage Chinese hamster lung fibroblasts of the line V79 by exposure to light was examined This treatment induced reduction of cellular ATP, GTP, of the NADH/NAD+ ratio and of oxygen consumption The present results indicate a close relationship between inhibition of respiration of irradiated cells and their ability to survive, eg 1 min of light exposure induced 90% inhibition of oxygen consumption and inactivation of approximately 95% of the cells, while the cellular content of ATP was reduced by only 15% This indicates that the mitochondria are one of the primary targets of 5-aminolevulinic acid (ALA)-mediated photochemotherapy (PCT) In the present study, ALA-PCT was combined with the modulators of the glycolysis and the respiration chain, levamisole (LEV) and Ionidamine (LND) A synergistic effect of combining ALA-PCT with non-toxic concentrations of LND was observed when LND was given prior to light exposure This synergism was observed despite a substantial LND-induced inhibition of PpIX formation At increasing doses of LND (>015 mM) the combination treatment becomes less efficient This is due to the inhibition of PpIX synthesis induced by LND A synergistic effect of ALA-PDT and LEV was found when LEV was given prior to light exposure This was at least partly due to an LEV-stimulated effect on ALA-induced PpIX formation However, it is not clear from the present results whether LEV may perturb energy metabolism in V79 cells since LEV alone did not reduce the energy charge or the NADH/NAD+ ratio When LEV or LND were given after ALA-PCT, these 2 treatment modalities acted in an additive or slightly synergistic manner © 1996 Wiley-Liss, Inc

24 citations


Journal Article
TL;DR: In this paper, some of the myths often associated to foreign direct investment in developing economies within the current context of globalization are discussed. Particular attention is dedicated to the fact that it is the financial sector the prevailing force in the process of globalization.
Abstract: The article approaches some of the myths often associated to foreign direct investment in developing economies within the current context of globalization. Particular attention is dedicated to the fact that it is the financial sector the prevailing force in the process of globalization.

17 citations