Institution
Tallinn University of Technology
Education•Tallinn, Estonia•
About: Tallinn University of Technology is a education organization based out in Tallinn, Estonia. It is known for research contribution in the topics: European union & Computer science. The organization has 3688 authors who have published 10313 publications receiving 145058 citations. The organization is also known as: Tallinn Technical University & Tallinna Tehnikaülikool.
Topics: European union, Computer science, Oil shale, Nonlinear system, Thin film
Papers published on a yearly basis
Papers
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TL;DR: A broad range of scientific and engineering disciplines are involved in a stack design, including thermal self-sustainability and efficiency, sealing technologies, manifold design, electrical connections and cell performance optimisation as discussed by the authors.
221 citations
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TL;DR: In this article, the authors identify the content of university entrepreneurship education and its impact on students' entrepreneurial intentions and find that what is offered is not necessarily the most demanded in entrepreneurship education as lectures and seminars are provided more, but networking and coaching activities are expected more by the students.
218 citations
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TL;DR: The results of this study have identified the cis-elements and transcription factors regulating neuronal activity-dependent transcription of human BDNF gene and demonstrated that CRE and PasRE elements in hBDNF promoter IX are required for the induction of this promoter by neuronal activity.
Abstract: Brain-derived neurotrophic factor (BDNF) is an important mediator of activity-dependent functions of the nervous system and its expression is dysregulated in several neuropsychiatric disorders. Regulation of rodent BDNF neuronal activity-dependent transcription has been relatively well characterized. Here, we have studied regulation of human BDNF (hBDNF) transcription by membrane depolarization of cultured mouse or rat primary cortical neurons expressing hBDNF gene or transfected with hBDNF promoter constructs, respectively. We identified an asymmetric E-box-like element, PasRE [basic helix-loop-helix (bHLH)-PAS transcription factor response element], in hBDNF promoter I and demonstrate that binding of this element by bHLH-PAS transcription factors ARNT2 (aryl hydrocarbon receptor nuclear translocator 2) and NPAS4 (neuronal PAS domain protein 4) is crucial for neuronal activity-dependent transcription from promoter I. We show that binding of CREB (cAMP response element-binding protein) to the cAMP/Ca(2+)-response element (CRE) in hBDNF promoter IV is critical for activity-dependent transcription from this promoter and that upstream stimulatory factor (USF) transcription factors also contribute to the activation by binding to the upstream stimulatory factor binding element (UBE) in hBDNF promoter IV. However, we report that full induction of hBDNF exon IV mRNA transcription is dependent on ARNT2 and NPAS4 binding to a PasRE in promoter IV. Finally, we demonstrate that CRE and PasRE elements in hBDNF promoter IX are required for the induction of this promoter by neuronal activity. Together, the results of this study have identified the cis-elements and transcription factors regulating neuronal activity-dependent transcription of human BDNF gene.
216 citations
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TL;DR: Progress and barriers for large-scale commercial usage of ILs in emerging biorefineries were critically evaluated using the principles of economies of scale and green chemistry in an environmentally sustainable way.
215 citations
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TL;DR: The combination of Fenton-like and the subsequent biological treatment resulted in the highest removal of PAH in creosote contaminated sand, and biodegradation with pre-ozonation was found to be the most effective technology for PAH elimination in peat.
210 citations
Authors
Showing all 3757 results
Name | H-index | Papers | Citations |
---|---|---|---|
James Chapman | 82 | 483 | 36468 |
Alexandre Alexakis | 67 | 540 | 17247 |
Bernard Waeber | 56 | 370 | 35335 |
Peter A. Andrekson | 54 | 573 | 12042 |
Charles S. Peirce | 51 | 167 | 11998 |
Lars M. Blank | 49 | 301 | 8011 |
Fushuan Wen | 49 | 465 | 9189 |
Mati Karelson | 48 | 207 | 10210 |
Ago Samoson | 46 | 119 | 8807 |
Zebo Peng | 45 | 359 | 7312 |
Petru Eles | 44 | 300 | 6749 |
Vijai Kumar Gupta | 43 | 301 | 6901 |
Eero Vasar | 43 | 263 | 6930 |
Rik Ossenkoppele | 42 | 192 | 6839 |
Tõnis Timmusk | 41 | 105 | 11056 |