Institution
Tallinn University of Technology
Education•Tallinn, Estonia•
About: Tallinn University of Technology is a education organization based out in Tallinn, Estonia. It is known for research contribution in the topics: European union & Oil shale. The organization has 3688 authors who have published 10313 publications receiving 145058 citations. The organization is also known as: Tallinn Technical University & Tallinna Tehnikaülikool.
Topics: European union, Oil shale, Thin film, Nonlinear system, Microstructure
Papers published on a yearly basis
Papers
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TL;DR: In this article, the authors develop and test a model that examines key drivers of visitors' COVID-19-induced social distancing behavior and its effect on their intent to use virtual reality-based (vs in-person) attraction site tours during and post-COVID19.
120 citations
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TL;DR: It is shown that extensive BDNF transcriptional autoregulation, encompassing all major BDNF transcripts, occurs also in vivo in the adult rat hippocampus during BDNF-induced LTP, and the existence of a stimulus-specific distal enhancer modulating BDNF gene expression is suggested.
Abstract: BDNF signaling via its transmembrane receptor TrkB has an important role in neuronal survival, differentiation, and synaptic plasticity. Remarkably, BDNF is capable of modulating its own expression levels in neurons, forming a transcriptional positive feedback loop. In the current study, we have investigated this phenomenon in primary cultures of rat cortical neurons using overexpression of dominant-negative forms of several transcription factors, including CREB, ATF2, C/EBP, USF, and NFAT. We show that CREB family transcription factors, together with the coactivator CBP/p300, but not the CRTC family, are the main regulators of rat BDNF gene expression after TrkB signaling. CREB family transcription factors are required for the early induction of all the major BDNF transcripts, whereas CREB itself directly binds only to BDNF promoter IV, is phosphorylated in response to BDNF-TrkB signaling, and activates transcription from BDNF promoter IV by recruiting CBP. Our complementary reporter assays with BDNF promoter constructs indicate that the regulation of BDNF by CREB family after BDNF-TrkB signaling is generally conserved between rat and human. However, we demonstrate that a nonconserved functional cAMP-responsive element in BDNF promoter IXa in humans renders the human promoter responsive to BDNF-TrkB-CREB signaling, whereas the rat ortholog is unresponsive. Finally, we show that extensive BDNF transcriptional autoregulation, encompassing all major BDNF transcripts, occurs also in vivo in the adult rat hippocampus during BDNF-induced LTP. Collectively, these results improve the understanding of the intricate mechanism of BDNF transcriptional autoregulation.SIGNIFICANCE STATEMENT Deeper understanding of stimulus-specific regulation of BDNF gene expression is essential to precisely adjust BDNF levels that are dysregulated in various neurological disorders. Here, we have elucidated the molecular mechanisms behind TrkB signaling-dependent BDNF mRNA induction and show that CREB family transcription factors are the main regulators of BDNF gene expression after TrkB signaling. Our results suggest that BDNF-TrkB signaling may induce BDNF gene expression in a distinct manner compared with neuronal activity. Moreover, our data suggest the existence of a stimulus-specific distal enhancer modulating BDNF gene expression.
118 citations
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TL;DR: In this paper, a lack of hard evidence on their actual impact on the actual impact of digital technologies on co-production and co-creation in public services has been identified, despite growing interest in the potential of digital technology to enhance co-productivity and collaboration in public service.
Abstract: Despite growing interest in the potential of digital technologies to enhance co-production and co-creation in public services, there is a lack of hard evidence on their actual impact. Conceptual fu...
118 citations
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15 Sep 2017
TL;DR: This chapter describes how to isolate and identify Penicillium species and its diversity in various habitats as well as insight in its selectivity.
Abstract: Penicillium is a genus of ascomycetous fungi and has an important role in various natural processes. The wide and ubiquitous presence of the Penicillium species has been researched in several studies. According to a comprehensive literature analysis Penicillium is one of the most common fungi occurring in various environments such as soil, air, and extreme environments (temperature, salinity, water deficiency, and pH) and is also associated with plants and specific food products. Due to its huge diversity and existence in extreme environments there is great potential in using it for various environmental, biotechnological, and industrial applications. This chapter describes how to isolate and identify Penicillium species and its diversity in various habitats as well as insight in its selectivity.
118 citations
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TL;DR: An unexpected increase in several interactions following JQ1 treatment that define negative functions for BRD3 in the regulation of rRNA synthesis and potentially RNAPII-dependent gene expression that result in decreased cell proliferation are identified.
117 citations
Authors
Showing all 3757 results
Name | H-index | Papers | Citations |
---|---|---|---|
James Chapman | 82 | 483 | 36468 |
Alexandre Alexakis | 67 | 540 | 17247 |
Bernard Waeber | 56 | 370 | 35335 |
Peter A. Andrekson | 54 | 573 | 12042 |
Charles S. Peirce | 51 | 167 | 11998 |
Lars M. Blank | 49 | 301 | 8011 |
Fushuan Wen | 49 | 465 | 9189 |
Mati Karelson | 48 | 207 | 10210 |
Ago Samoson | 46 | 119 | 8807 |
Zebo Peng | 45 | 359 | 7312 |
Petru Eles | 44 | 300 | 6749 |
Vijai Kumar Gupta | 43 | 301 | 6901 |
Eero Vasar | 43 | 263 | 6930 |
Rik Ossenkoppele | 42 | 192 | 6839 |
Tõnis Timmusk | 41 | 105 | 11056 |