Showing papers by "Tata Institute of Fundamental Research published in 2011"

Determination of jet energy calibration and transverse momentum resolution in CMS

Abstract: Measurements of the jet energy calibration and transverse momentum resolution in CMS are presented, performed with a data sample collected in proton-proton collisions at a centre-of-mass energy of 7TeV, corresponding to an integrated luminosity of 36pb−1. The transverse momentum balance in dijet and γ/Z+jets events is used to measure the jet energy response in the CMS detector, as well as the transverse momentum resolution. The results are presented for three different methods to reconstruct jets: a calorimeter-based approach, the ``Jet-Plus-Track'' approach, which improves the measurement of calorimeter jets by exploiting the associated tracks, and the ``Particle Flow'' approach, which attempts to reconstruct individually each particle in the event, prior to the jet clustering, based on information from all relevant subdetectors

Observation and studies of jet quenching in PbPb collisions at √sNN=2.76 TeV

Abstract: Jet production in PbPb collisions at a nucleon-nucleon center-of-mass energy of 2.76 TeV was studied with the CMS detector at the LHC, using a data sample corresponding to an integrated luminosity of 6.7 inverse microbarns. Jets are reconstructed using the energy deposited in the CMS calorimeters and studied as a function of collision centrality. With increasing collision centrality, a striking imbalance in dijet transverse momentum is observed, consistent with jet quenching. The observed effect extends from the lower cut-off used in this study (jet transverse momentum = 120 GeV/c) up to the statistical limit of the available data sample (jet transverse momentum approximately 210 GeV/c). Correlations of charged particle tracks with jets indicate that the momentum imbalance is accompanied by a softening of the fragmentation pattern of the second most energetic, away-side jet. The dijet momentum balance is recovered when integrating low transverse momentum particles distributed over a wide angular range relative to the direction of the away-side jet.

Hydrodynamics from charged black branes

Abstract: We extend the recent work on fluid-gravity correspondence to charged black-branes by determining the metric duals to arbitrary charged fluid configuration up to second order in the boundary derivative expansion. We also derive the energy-momentum tensor and the charge current for these configurations up to second order in the boundary derivative expansion. We find a new term in the charge current when there is a bulk Chern-Simons interaction thus resolving an earlier discrepancy between thermodynamics of charged rotating black holes and boundary hydrodynamics. We have also confirmed that all our expressions are covariant under boundary Weyl-transformations as expected.

Enhanced magneto-optical effects in magnetoplasmonic crystals

Abstract: Plasmonics allows light to be localized on length scales much shorter than its wavelength, which makes it possible to integrate photonics and electronics on the nanoscale. Magneto-optical materials are appealing for applications in plasmonics because they open up the possibility of using external magnetic fields in plasmonic devices. Here, we fabricate a new magneto-optical material, a magnetoplasmonic crystal, that consists of a nanostructured noble-metal film on top of a ferromagnetic dielectric, and we demonstrate an enhanced Kerr effect with this material. Such magnetoplasmonic crystals could have applications in telecommunications, magnetic field sensing and all-optical magnetic data storage.

Chern-Simons Theory with Vector Fermion Matter

Abstract: We study three dimensional conformal field theories described by U(N) Chern-Simons theory at level k coupled to massless fermions in the fundamental representation. By solving a Schwinger-Dyson equation in lightcone gauge, we compute the exact planar free energy of the theory at finite temperature on R^2 as a function of the 't Hooft coupling lambda=N/k. Employing a dimensional reduction regularization scheme, we find that the free energy vanishes at |lambda|=1; the conformal theory does not exist for |lambda|>1. We analyze the operator spectrum via the anomalous conservation relation for higher spin currents, and in particular show that the higher spin currents do not develop anomalous dimensions at leading order in 1/N. We present an integral equation whose solution in principle determines all correlators of these currents at leading order in 1/N and present explicit perturbative results for all three point functions up to two loops. We also discuss a lightcone Hamiltonian formulation of this theory where a W-infinity algebra arises. The maximally supersymmetric version of our theory is ABJ model with one gauge group taken to be U(1), demonstrating that a pure higher spin gauge theory arises as a limit of string theory.

Search for supersymmetry at the LHC in events with jets and missing transverse energy

Abstract: A search for events with jets and missing transverse energy is performed in a data sample of pp collisions collected at sqrt(s) = 7 TeV by the CMS experiment at the LHC. The analyzed data sample corresponds to an integrated luminosity of 1.14 inverse femtobarns. In this search, a kinematic variable, alphaT, is used as the main discriminator between events with genuine and misreconstructed missing transverse energy. No excess of events over the standard model expectation is found. Exclusion limits in the parameter space of the constrained minimal supersymmetric extension of the standard model are set. In this model, squark masses below 1.1 TeV are excluded at 95% CL. Gluino masses below 1.1 TeV are also ruled out at 95% CL for values of the universal scalar mass parameter below 500 GeV.

Forward-backward asymmetry in top quark-antiquark production

Abstract: We present a measurement of forward-backward asymmetry in top quark-antiquark production in proton-antiproton collisions in the final state containing a lepton and at least four jets. Using a dataset corresponding to an integrated luminosity of $5.4\,\mathrm {fb}^{-1}$, collected by the \DZ\ experiment at the Fermilab Tevatron Collider, we measure the \ttbar\ forward-backward asymmetry to be $(9.2 \pm 3.7)$% at the reconstruction level. When corrected for detector acceptance and resolution, the asymmetry is found to be $(19.6 \pm 6.5)$%. We also measure a corrected asymmetry based on the lepton from a top quark decay, found to be $(15.2 \pm 4.0)$%. The results are compared to predictions based on the next-to-leading-order QCD generator {\sc mc@nlo}. The sensitivity of the measured and predicted asymmetries to the modeling of gluon radiation is discussed.

Scale for the phase diagram of quantum chromodynamics.

Abstract: Matter described by quantum chromodynamics (QCD), the theory of strong interactions, may undergo phase transitions when its temperature and the chemical potentials are varied. QCD at finite temperature is studied in the laboratory by colliding heavy ions at varying beam energies. We present a test of QCD in the nonperturbative domain through a comparison of thermodynamic fluctuations predicted in lattice computations with the experimental data of baryon number distributions in high-energy heavy ion collisions. This study provides evidence for thermalization in these collisions and allows us to find the crossover temperature between normal nuclear matter and a deconfined phase called the quark gluon plasma. This value allows us to set a scale for the phase diagram of QCD.

Upsilon production cross section in pp collisions at √s=7 TeV

Abstract: The Upsilon production cross section in proton-proton collisions at sqrt(s) = 7 TeV is measured using a data sample collected with the CMS detector at the LHC, corresponding to an integrated luminosity of 3.1 +/- 0.3 inverse picobarns. Integrated over the rapidity range |y|<2, we find the product of the Upsilon(1S) production cross section and branching fraction to dimuons to be sigma(pp to Upsilon(1S) X) B(Upsilon(1S) to mu+ mu-) = 7.37 +/- 0.13^{+0.61}_{-0.42}\pm 0.81 nb, where the first uncertainty is statistical, the second is systematic, and the third is associated with the estimation of the integrated luminosity of the data sample. This cross section is obtained assuming unpolarized Upsilon(1S) production. If the Upsilon(1S) production polarization is fully transverse or fully longitudinal the cross section changes by about 20%. We also report the measurement of the Upsilon(1S), Upsilon(2S), and Upsilon(3S) differential cross sections as a function of transverse momentum and rapidity.

Measurement of the inclusive W and Z production cross sections in pp collisions at √s = 7 TeV with the CMS experiment

Abstract: A measurement of inclusive W and Z production cross sections in pp collisions at sqrt(s)=7 TeV is presented. The electron and muon decay channels are analyzed in a data sample collected with the CMS detector at the LHC and corresponding to an integrated luminosity of 36 inverse picobarns. The measured inclusive cross sections are sigma(pp-> WX) B(W-> l nu) = 10.30 +/- 0.02 (stat.) +/- 0.10 (syst.) +/- 0.10 (th.) +/- 0.41 (lumi.) nb and sigma(pp -> ZX) B(Z-> l^+l^-) = 0.974 +/- 0.007 (stat.) +/- 0.007 (syst.) +/- 0.018 (th.) +/- 0.039 (lumi.) nb, limited to the dilepton invariant mass range 60 to 120 GeV. The luminosity-independent cross section ratios are [sigma(pp->WX) B(W-> l nu)]/[sigma(pp-> ZX) B(Z->l^+l^-)] = 10.54 +/- 0.07 (stat.) +/- 0.08 (syst.) +/- 0.16 (th.) and [sigma(pp->W^+X) B(W^+ -> l^+nu)] / [sigma(pp->W^- X) B(W^- -> l^- nu)] = 1.421 +/- 0.006 (stat.) +/- 0.014 (syst.) +/- 0.029 (th.). The measured values agree with next-to-next-to-leading order QCD cross section calculations based on recent parton distribution functions.

Measurements of inclusive W and Z cross sections in pp collisions at \sqrt {s} = 7 TeV

Abstract: Measurements of inclusive W and Z boson production cross sections in pp collisions at sqrt(s)=7 TeV are presented, based on 2.9 inverse picobarns of data recorded by the CMS detector at the LHC. The measurements, performed in the electron and muon decay channels, are combined to give sigma(pp to WX) times B(W to muon or electron + neutrino) = 9.95 \pm 0.07(stat.) \pm 0.28(syst.) \pm 1.09(lumi.) nb and sigma(pp to ZX) times B(Z to oppositely charged muon or electron pairs) = 0.931 \pm 0.026(stat.) \pm 0.023(syst.) \pm 0.102(lumi.) nb. Theoretical predictions, calculated at the next-to-next-to-leading order in QCD using recent parton distribution functions, are in agreement with the measured cross sections. Ratios of cross sections, which incur an experimental systematic uncertainty of less than 4%, are also reported.

Recent developments in gravitational collapse and spacetime singularities

Abstract: It is now known that when a massive star collapses under the force of its own gravity, the final fate of such a continual gravitational collapse will be either a black hole or a naked singularity under a wide variety of physically reasonable circumstances within the framework of general theory of relativity. The research of recent years has provided considerable clarity and insight on stellar collapse, black holes and the nature and structure of spacetime singularities. We discuss several of these developments here. There are also important fundamental questions that remain unanswered on the final fate of collapse of a massive matter cloud in gravitation theory, especially on naked singularities which are hypothetical astrophysical objects and on the nature of cosmic censorship hypothesis. These issues have key implications for our understanding on black hole physics today, its astrophysical applications, and for certain basic questions in cosmology and possible quantum theories of gravity. We consider these issues here and summarize recent results and current progress in these directions. The emerging astrophysical and observational perspectives and implications are discussed, with particular reference to the properties of accretion disks around black holes and naked singularities, which may provide characteristic signatures and could help distinguish these objects.

Indications of suppression of excited? States in Pb-Pb collisions at sNN2.76 TeV

Abstract: A comparison of the relative yields of Upsilon resonances in the mu(+) mu(-) decay channel in PbPb and pp collisions at a centre-of-mass energy per nucleon pair of 2.76 TeV, is performed with data collected with the CMS detector at the LHC. Using muons of transverse momentum above 4 GeV/c and pseudorapidity below 2.4, the double ratio of the Upsilon(2S) and Upsilon(3S) excited states to the Upsilon(1S) ground state in PbPb and pp collisions,(Upsilon(2S+3S)/Upsilon(1S)[PbPb])/(Upsilon(2S+3S)/Upsilon(1S)[pp]), is found to be 0.31 - 0.15 + 0.19 (stat.) +/- 0.03 (syst.). The probability to obtain the measured value, or lower, if the true double ratio is unity, has been calculated to be less than 1%.

Root apoplastic barriers block Na+ transport to shoots in rice (Oryza sativa L.)

Abstract: Rice is an important crop that is very sensitive to salinity. However, some varieties differ greatly in this feature, making investigations of salinity tolerance mechanisms possible. The cultivar Pokkali is salinity tolerant and is known to have more extensive hydrophobic barriers in its roots than does IR20, a more sensitive cultivar. These barriers located in the root endodermis and exodermis prevent the direct entry of external fluid into the stele. However, it is known that in the case of rice, these barriers are bypassed by most of the Na+ that enters the shoot. Exposing plants to a moderate stress of 100 mM NaCl resulted in deposition of additional hydrophobic aliphatic suberin in both cultivars. The present study demonstrated that Pokkali roots have a lower permeability to water (measured using a pressure chamber) than those of IR20. Conditioning plants with 100 mM NaCl effectively reduced Na+ accumulation in the shoot and improved survival of the plants when they were subsequently subjected to a lethal stress of 200 mM NaCl. The Na+ accumulated during the conditioning period was rapidly released when the plants were returned to the control medium. It has been suggested that the location of the bypass flow is around young lateral roots, the early development of which disrupts the continuity of the endodermal and exodermal Casparian bands. However, in the present study, the observed increase in lateral root densities during stress in both cultivars did not correlate with bypass flow. Overall the data suggest that in rice roots Na+ bypass flow is reduced by the deposition of apoplastic barriers, leading to improved plant survival under salt stress.

Charged particle multiplicities in pp interactions at sqrt(s) = 0.9, 2.36, and 7 TeV

Abstract: Measurements of primary charged hadron multiplicity distributions are presented for non-single-diffractive events in proton-proton collisions at centre-of-mass energies of sqrt(s) = 0.9, 2.36, and 7 TeV, in five pseudorapidity ranges from |eta|<0.5 to |eta|<2.4. The data were collected with the minimum-bias trigger of the CMS experiment during the LHC commissioning runs in 2009 and the 7 TeV run in 2010. The multiplicity distribution at sqrt(s) = 0.9 TeV is in agreement with previous measurements. At higher energies the increase of the mean multiplicity with sqrt(s) is underestimated by most event generators. The average transverse momentum as a function of the multiplicity is also presented. The measurement of higher-order moments of the multiplicity distribution confirms the violation of Koba-Nielsen-Olesen scaling that has been observed at lower energies.

Prompt and non-prompt J/ψ production in pp collisions at √s = 7 TeV

Abstract: The production of J/psi mesons is studied in pp collisions at sqrt(s)=7 TeV with the CMS experiment at the LHC. The measurement is based on a dimuon sample corresponding to an integrated luminosity of 314 inverse nanobarns. The J/psi differential cross section is determined, as a function of the J/psi transverse momentum, in three rapidity ranges. A fit to the decay length distribution is used to separate the prompt from the non-prompt (b hadron to J/psi) component. Integrated over J/psi transverse momentum from 6.5 to 30 GeV/c and over rapidity in the range |y| < 2.4, the measured cross sections, times the dimuon decay branching fraction, are 70.9 \pm 2.1 (stat.) \pm 3.0 (syst.) \pm 7.8(luminosity) nb for prompt J/psi mesons assuming unpolarized production and 26.0 \pm 1.4 (stat.) \pm 1.6 (syst.) \pm 2.9 (luminosity) nb for J/psi mesons from b-hadron decays.

Phase Fluctuations in a Strongly Disordered s-Wave NbN Superconductor Close to the Metal-Insulator Transition

Abstract: We explore the role of phase fluctuations in a three-dimensional $s$-wave superconductor, NbN, as we approach the critical disorder for destruction of the superconducting state. Close to critical disorder, we observe a finite gap in the electronic spectrum which persists at temperatures well above ${T}_{c}$. The superfluid density is strongly suppressed at low temperatures and evolves towards a linear-$T$ variation at higher temperatures. These observations provide strong evidence that phase fluctuations play a central role in the formation of a pseudogap state in a disordered $s$-wave superconductor.

Quantum black holes, localization, and the topological string

Abstract: We use localization to evaluate the functional integral of string field theory on AdS 2 × S 2 background corresponding to the near horizon geometry of supersymmetric black holes in 4d compactifications with $ \mathcal{N} = 2 $ supersymmetry. In particular, for a theory containing n v + 1 vector multiplets, we show that the functional integral localizes exactly onto an ordinary integral over a finite-dimensional submanifold in the field space labeling a continuous family of instanton solutions in which auxiliary fields in the vector multiplets are excited with nontrivial dependence on AdS 2 coordinates. These localizing solutions are universal in that they follow from the off-shell supersymmetry transformations and do not depend on the choice of the action. They are parametrized by n v + 1 real parameters {C I; I = 0,…, n v } that correspond to the values of the auxiliary fields at the center of AdS 2. In the Type-IIA frame, assuming D-terms evaluate to zero on the solutions for reasons of supersymmetry, the classical part of the integrand equals the absolute square of the partition function of the topological string as conjectured by Ooguri, Strominger, and Vafa; however evaluated at the off-shell values of scalar fields at the center of AdS 2. In addition, there are contributions from one-loop determinants, brane-instantons, and nonperturbative orbifolds that are in principle computable. These results thus provide a concrete method to compute exact quantum entropy of these black holes including all perturbative and nonperturbative corrections and can be used to establish a precise relation between the quantum degeneracies of black holes and the topological string.

The GMRT Epoch of Reionization experiment: a new upper limit on the neutral hydrogen power spectrum at z≈ 8.6

Abstract: We present a new upper limit to the 21-cm power spectrum during the Epoch of Reionization (EoR) which constrains reionization models with an unheated IGM. The GMRT-EoR experiment is an ongoing effort to make a statistical detection of the power spectrum of 21-cm neutral hydrogen emission at redshift z ∼ 9. Data from this redshift constrain models of the EoR, the end of the Dark Ages arising from the formation of the first bright UV sources, probably stars or mini-quasars. We present results from approximately 50 h of observations with the Giant Metrewave Radio Telescope in India from 2007 December. We describe radio-frequency interference (RFI) localization schemes which allow bright sources on the ground to be identified and physically removed in addition to automated flagging. Singular-value decomposition is used to remove the remaining broad-band RFI by identifying ground sources with large eigenvalues. Foregrounds are modelled using a piecewise linear filter and the power spectrum is measured using cross-correlations of foreground-subtracted images.

Measurement of the lepton charge asymmetry in inclusive W production in pp collisions at √s=7 TeV

Abstract: A measurement of the lepton charge asymmetry in inclusive pp to WX production at sqrt(s)= 7 TeV is presented based on data recorded by the CMS detector at the LHC and corresponding to an integrated luminosity of 36 inverse picobarns. This high precision measurement of the lepton charge asymmetry, performed in both the W to e nu and W to mu nu channels, provides new insights into parton distribution functions.

On the Capacity and Diversity-Multiplexing Tradeoff of the Two-Way Relay Channel

Abstract: In a two-way relay channel, two sources use one or more relay nodes to exchange data with each other. This paper considers a multiple input multiple output (MIMO) two-way relay channel, where each relay node has one or more antennas. Optimal relay transmission strategies for the two-way relay channel are derived to maximize the achievable rate with amplify and forward (AF) at each relay and to achieve the optimal diversity-multiplexing tradeoff (DM-tradeoff). To maximize the achievable rate with AF, an iterative algorithm is proposed which solves a power minimization problem subject to minimum signal-to-interference-and-noise ratio constraints at every step. The power minimization problem is nonconvex. The Karush Kuhn Tucker conditions, however, are shown to be sufficient for optimality. Capacity scaling law of the two-way relay channel with increasing number of relays is also established by deriving a lower and upper bound on the capacity region of the two-way relay channel. To achieve the optimal DM-tradeoff, a compress and forward strategy is proposed and its DM-tradeoff is derived. For the full-duplex two-way relay channel, the proposed strategy achieves the optimal DM-tradeoff, while for the half-duplex case the proposed strategy is shown to achieve the optimal DM-tradeoff under some conditions.

Sirt1 and mir-9 expression is regulated during glucose-stimulated insulin secretion in pancreatic β-islets

Abstract: MicroRNA mir-9 is speculated to be involved in insulin secretion because of its ability to regulate exocytosis. Sirt1 is an NAD-dependent protein deacetylase and a critical factor in the modulation of cellular responses to altered metabolic flux. It has also been shown recently to control insulin secretion from pancreatic β-islets. However, little is known about the regulation of Sirt1 and mir-9 levels in pancreatic β-cells, particularly during glucose-dependent insulin secretion. In this article, we report that mir-9 and Sirt1 protein levels are actively regulated in vivo in β-islets during glucose-dependent insulin secretion. Our data also demonstrates that mir-9 targets and regulates Sirt1 expression in insulin-secreting cells. This targeting is relevant in pancreatic β-islets, where we show a reduction in Sirt1 protein levels when mir-9 expression is high during glucose-dependent insulin secretion. This functional interplay between insulin secretion, mir-9 and Sirt1 expression could be relevant in diabetes. It also highlights the crosstalk between an NAD-dependent protein deacetylase and microRNA in pancreatic β-cells.

Minimum Information About a Simulation Experiment (MIASE)

Abstract: Reproducibility of experiments is a basic requirement for science. Minimum Information (MI) guidelines have proved a helpful means of enabling reuse of existing work in modern biology. The Minimum Information Required in the Annotation of Models (MIRIAM) guidelines promote the exchange and reuse of biochemical computational models. However, information about a model alone is not sufficient to enable its efficient reuse in a computational setting. Advanced numerical algorithms and complex modeling workflows used in modern computational biology make reproduction of simulations difficult. It is therefore essential to define the core information necessary to perform simulations of those models. The Minimum Information About a Simulation Experiment (MIASE, Glossary in Box 1) describes the minimal set of information that must be provided to make the description of a simulation experiment available to others. It includes the list of models to use and their modifications, all the simulation procedures to apply and in which order, the processing of the raw numerical results, and the description of the final output. MIASE allows for the reproduction of any simulation experiment. The provision of this information, along with a set of required models, guarantees that the simulation experiment represents the intention of the original authors. Following MIASE guidelines will thus improve the quality of scientific reporting, and will also allow collaborative, more distributed efforts in computational modeling and simulation of biological processes.

A Note on CFT Correlators in Three Dimensions

Abstract: In this note we present a simple method of constructing general conformally invariant three point functions of operators of various spins in three dimensions. Upon further imposing current conservation conditions, we find new parity violating structures for the three point functions involving either the stress-energy tensor, spin one currents, or higher spin currents. We find that all parity preserving structures for conformally invariant three point functions of higher spin conserved currents can be realized by free fields, whereas there is at most one parity violating structure for three point functions for each set of spins, which is not realized by free fields.

Dependence on pseudorapidity and on centrality of charged hadron production in PbPb collisions at root s(NN)=2.76 TeV

Abstract: A measurement is presented of the charged hadron multiplicity in hadronic PbPb collisions, as a function of pseudorapidity and centrality, at a collision energy of 2.76 TeV per nucleon pair. The data sample is collected using the CMS detector and a minimum-bias trigger, with the CMS solenoid off. The number of charged hadrons is measured both by counting the number of reconstructed particle hits and by forming hit doublets of pairs of layers in the pixel detector. The two methods give consistent results. The charged hadron multiplicity density dN(ch)/d eta, evaluated at eta=0 for head-on collisions, is found to be 1612 +/- 55, where the uncertainty is dominated by systematic effects. Comparisons of these results to previous measurements and to various models are also presented.

Histopathologic characterization of the BTBR mouse model of autistic-like behavior reveals selective changes in neurodevelopmental proteins and adult hippocampal neurogenesis

Abstract: The inbred mouse strain BTBR T+ tf/J (BTBR) exhibits behavioral deficits that mimic the core deficits of autism. Neuroanatomically, the BTBR strain is also characterized by a complete absence of the corpus callosum. The goal of this study was to identify novel molecular and cellular changes in the BTBR mouse, focusing on neuronal, synaptic, glial and plasticity markers in the limbic system as a model for identifying putative molecular and cellular substrates associated with autistic behaviors. Forebrains of 8 to 10-week-old male BTBR and age-matched C57Bl/6J control mice were evaluated by immunohistochemistry using free-floating and paraffin embedded sections. Twenty antibodies directed against antigens specific to neurons, synapses and glia were used. Nissl, Timm and acetylcholinesterase (AchE) stains were performed to assess cytoarchitecture, mossy fibers and cholinergic fiber density, respectively. In the hippocampus, quantitative stereological estimates for the mitotic marker bromodeoxyuridine (BrdU) were performed to determine hippocampal progenitor proliferation, survival and differentiation, and brain-derived neurotrophic factor (BDNF) mRNA was quantified by in situ hybridization. Quantitative image analysis was performed for NG2, doublecortin (DCX), NeuroD, GAD67 and Poly-Sialic Acid Neural Cell Adhesion Molecule (PSA-NCAM). In midline structures including the region of the absent corpus callosum of BTBR mice, the myelin markers 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) and myelin basic protein (MBP) were reduced, and the oligodendrocyte precursor NG2 was increased. MBP and CNPase were expressed in small ectopic white matter bundles within the cingulate cortex. Microglia and astrocytes showed no evidence of gliosis, yet orientations of glial fibers were altered in specific white-matter areas. In the hippocampus, evidence of reduced neurogenesis included significant reductions in the number of doublecortin, PSA-NCAM and NeuroD immunoreactive cells in the subgranular zone of the dentate gyrus, and a marked reduction in the number of 5-bromo-2'-deoxyuridine (BrdU) positive progenitors. Furthermore, a significant and profound reduction in BDNF mRNA was seen in the BTBR dentate gyrus. No significant differences were seen in the expression of AchE, mossy fiber synapses or immunoreactivities of microtubule-associated protein MAP2, parvalbumin and glutamate decarboxylase GAD65 or GAD67 isoforms. We documented modest and selective alterations in glia, neurons and synapses in BTBR forebrain, along with reduced neurogenesis in the adult hippocampus. Of all markers examined, the most distinctive changes were seen in the neurodevelopmental proteins NG2, PSA-NCAM, NeuroD and DCX. Our results are consistent with aberrant development of the nervous system in BTBR mice, and may reveal novel substrates to link callosal abnormalities and autistic behaviors. The changes that we observed in the BTBR mice suggest potential novel therapeutic strategies for intervention in autism spectrum disorders.