scispace - formally typeset
Search or ask a question

Showing papers by "Tata Institute of Fundamental Research published in 2020"


Journal ArticleDOI
B. P. Abbott1, R. Abbott1, T. D. Abbott2, Sheelu Abraham3  +1271 moreInstitutions (145)
TL;DR: In 2019, the LIGO Livingston detector observed a compact binary coalescence with signal-to-noise ratio 12.9 and the Virgo detector was also taking data that did not contribute to detection due to a low SINR but were used for subsequent parameter estimation as discussed by the authors.
Abstract: On 2019 April 25, the LIGO Livingston detector observed a compact binary coalescence with signal-to-noise ratio 12.9. The Virgo detector was also taking data that did not contribute to detection due to a low signal-to-noise ratio, but were used for subsequent parameter estimation. The 90% credible intervals for the component masses range from to if we restrict the dimensionless component spin magnitudes to be smaller than 0.05). These mass parameters are consistent with the individual binary components being neutron stars. However, both the source-frame chirp mass and the total mass of this system are significantly larger than those of any other known binary neutron star (BNS) system. The possibility that one or both binary components of the system are black holes cannot be ruled out from gravitational-wave data. We discuss possible origins of the system based on its inconsistency with the known Galactic BNS population. Under the assumption that the signal was produced by a BNS coalescence, the local rate of neutron star mergers is updated to 250-2810.

1,189 citations


Journal ArticleDOI
Richard J. Abbott1, T. D. Abbott2, Sheelu Abraham3, Fausto Acernese4  +1334 moreInstitutions (150)
TL;DR: In this paper, the authors reported the observation of a compact binary coalescence involving a 222 −243 M ⊙ black hole and a compact object with a mass of 250 −267 M ⋆ (all measurements quoted at the 90% credible level) The gravitational-wave signal, GW190814, was observed during LIGO's and Virgo's third observing run on 2019 August 14 at 21:10:39 UTC and has a signal-to-noise ratio of 25 in the three-detector network.
Abstract: We report the observation of a compact binary coalescence involving a 222–243 M ⊙ black hole and a compact object with a mass of 250–267 M ⊙ (all measurements quoted at the 90% credible level) The gravitational-wave signal, GW190814, was observed during LIGO's and Virgo's third observing run on 2019 August 14 at 21:10:39 UTC and has a signal-to-noise ratio of 25 in the three-detector network The source was localized to 185 deg2 at a distance of ${241}_{-45}^{+41}$ Mpc; no electromagnetic counterpart has been confirmed to date The source has the most unequal mass ratio yet measured with gravitational waves, ${0112}_{-0009}^{+0008}$, and its secondary component is either the lightest black hole or the heaviest neutron star ever discovered in a double compact-object system The dimensionless spin of the primary black hole is tightly constrained to ≤007 Tests of general relativity reveal no measurable deviations from the theory, and its prediction of higher-multipole emission is confirmed at high confidence We estimate a merger rate density of 1–23 Gpc−3 yr−1 for the new class of binary coalescence sources that GW190814 represents Astrophysical models predict that binaries with mass ratios similar to this event can form through several channels, but are unlikely to have formed in globular clusters However, the combination of mass ratio, component masses, and the inferred merger rate for this event challenges all current models of the formation and mass distribution of compact-object binaries

913 citations


Journal ArticleDOI
R. Abbott1, T. D. Abbott2, Sheelu Abraham3, Fausto Acernese4  +1332 moreInstitutions (150)
TL;DR: It is inferred that the primary black hole mass lies within the gap produced by (pulsational) pair-instability supernova processes, with only a 0.32% probability of being below 65 M⊙, which can be considered an intermediate mass black hole (IMBH).
Abstract: On May 21, 2019 at 03:02:29 UTC Advanced LIGO and Advanced Virgo observed a short duration gravitational-wave signal, GW190521, with a three-detector network signal-to-noise ratio of 14.7, and an estimated false-alarm rate of 1 in 4900 yr using a search sensitive to generic transients. If GW190521 is from a quasicircular binary inspiral, then the detected signal is consistent with the merger of two black holes with masses of 85_{-14}^{+21} M_{⊙} and 66_{-18}^{+17} M_{⊙} (90% credible intervals). We infer that the primary black hole mass lies within the gap produced by (pulsational) pair-instability supernova processes, with only a 0.32% probability of being below 65 M_{⊙}. We calculate the mass of the remnant to be 142_{-16}^{+28} M_{⊙}, which can be considered an intermediate mass black hole (IMBH). The luminosity distance of the source is 5.3_{-2.6}^{+2.4} Gpc, corresponding to a redshift of 0.82_{-0.34}^{+0.28}. The inferred rate of mergers similar to GW190521 is 0.13_{-0.11}^{+0.30} Gpc^{-3} yr^{-1}.

876 citations


Journal ArticleDOI
Richard J. Abbott1, T. D. Abbott2, Sheelu Abraham3, Fausto Acernese4  +1330 moreInstitutions (149)
TL;DR: In this article, the authors reported the observation of gravitational waves from a binary-black-hole coalescence during the first two weeks of LIGO and Virgo's third observing run.
Abstract: We report the observation of gravitational waves from a binary-black-hole coalescence during the first two weeks of LIGO’s and Virgo’s third observing run. The signal was recorded on April 12, 2019 at 05∶30∶44 UTC with a network signal-to-noise ratio of 19. The binary is different from observations during the first two observing runs most notably due to its asymmetric masses: a ∼30 M⊙ black hole merged with a ∼8 M⊙ black hole companion. The more massive black hole rotated with a dimensionless spin magnitude between 0.22 and 0.60 (90% probability). Asymmetric systems are predicted to emit gravitational waves with stronger contributions from higher multipoles, and indeed we find strong evidence for gravitational radiation beyond the leading quadrupolar order in the observed signal. A suite of tests performed on GW190412 indicates consistency with Einstein’s general theory of relativity. While the mass ratio of this system differs from all previous detections, we show that it is consistent with the population model of stellar binary black holes inferred from the first two observing runs.

507 citations


Journal ArticleDOI
TL;DR: This review focuses on recent additions to TURBOMOLE’s functionality, including excited-state methods, RPA and Green's function methods, relativistic approaches, high-order molecular properties, solvation effects, and periodic systems.
Abstract: TURBOMOLE is a collaborative, multi-national software development project aiming to provide highly efficient and stable computational tools for quantum chemical simulations of molecules, clusters, periodic systems, and solutions. The TURBOMOLE software suite is optimized for widely available, inexpensive, and resource-efficient hardware such as multi-core workstations and small computer clusters. TURBOMOLE specializes in electronic structure methods with outstanding accuracy-cost ratio, such as density functional theory including local hybrids and the random phase approximation (RPA), GW-Bethe-Salpeter methods, second-order Moller-Plesset theory, and explicitly correlated coupled-cluster methods. TURBOMOLE is based on Gaussian basis sets and has been pivotal for the development of many fast and low-scaling algorithms in the past three decades, such as integral-direct methods, fast multipole methods, the resolution-of-the-identity approximation, imaginary frequency integration, Laplace transform, and pair natural orbital methods. This review focuses on recent additions to TURBOMOLE's functionality, including excited-state methods, RPA and Green's function methods, relativistic approaches, high-order molecular properties, solvation effects, and periodic systems. A variety of illustrative applications along with accuracy and timing data are discussed. Moreover, available interfaces to users as well as other software are summarized. TURBOMOLE's current licensing, distribution, and support model are discussed, and an overview of TURBOMOLE's development workflow is provided. Challenges such as communication and outreach, software infrastructure, and funding are highlighted.

489 citations


Journal ArticleDOI
03 Jul 2020-Science
TL;DR: High-resilience positive-intrinsic-negative perovskite solar cells are demonstrated by incorporating a piperidinium-based ionic compound into the formamid inium-cesium lead-trihalide perovSKite absorber, and detailed degradation routes that contribute to the failure of aged cells are revealed.
Abstract: Longevity has been a long-standing concern for hybrid perovskite photovoltaics. We demonstrate high-resilience positive-intrinsic-negative perovskite solar cells by incorporating a piperidinium-based ionic compound into the formamidinium-cesium lead-trihalide perovskite absorber. With the bandgap tuned to be well suited for perovskite-on-silicon tandem cells, this piperidinium additive enhances the open-circuit voltage and cell efficiency. This additive also retards compositional segregation into impurity phases and pinhole formation in the perovskite absorber layer during aggressive aging. Under full-spectrum simulated sunlight in ambient atmosphere, our unencapsulated and encapsulated cells retain 80 and 95% of their peak and post-burn-in efficiencies for 1010 and 1200 hours at 60° and 85°C, respectively. Our analysis reveals detailed degradation routes that contribute to the failure of aged cells.

378 citations


Journal ArticleDOI
Richard J. Abbott1, T. D. Abbott2, Sheelu Abraham3, Fausto Acernese4  +1329 moreInstitutions (150)
TL;DR: The GW190521 signal is consistent with a binary black hole (BBH) merger source at redshift 0.13-0.30 Gpc-3 yr-1.8 as discussed by the authors.
Abstract: The gravitational-wave signal GW190521 is consistent with a binary black hole (BBH) merger source at redshift 0.8 with unusually high component masses, 85-14+21 M o˙ and 66-18+17 M o˙, compared to previously reported events, and shows mild evidence for spin-induced orbital precession. The primary falls in the mass gap predicted by (pulsational) pair-instability supernova theory, in the approximate range 65-120 M o˙. The probability that at least one of the black holes in GW190521 is in that range is 99.0%. The final mass of the merger (142-16+28 M o˙) classifies it as an intermediate-mass black hole. Under the assumption of a quasi-circular BBH coalescence, we detail the physical properties of GW190521's source binary and its post-merger remnant, including component masses and spin vectors. Three different waveform models, as well as direct comparison to numerical solutions of general relativity, yield consistent estimates of these properties. Tests of strong-field general relativity targeting the merger-ringdown stages of the coalescence indicate consistency of the observed signal with theoretical predictions. We estimate the merger rate of similar systems to be 0.13-0.11+0.30 Gpc-3 yr-1. We discuss the astrophysical implications of GW190521 for stellar collapse and for the possible formation of black holes in the pair-instability mass gap through various channels: via (multiple) stellar coalescences, or via hierarchical mergers of lower-mass black holes in star clusters or in active galactic nuclei. We find it to be unlikely that GW190521 is a strongly lensed signal of a lower-mass black hole binary merger. We also discuss more exotic possible sources for GW190521, including a highly eccentric black hole binary, or a primordial black hole binary.

347 citations


Journal ArticleDOI
TL;DR: In vitro generated α-Syn liquid-like droplets eventually undergo a liquid-to-solid transition and form an amyloid hydrogel that contains oligomers and fibrillar species and this work provides detailed insights into the phase-separation behaviour of natively unstructured α- Syn and its conversion to a disease-associated aggregated state, which is highly relevant in Parkinson's disease pathogenesis.
Abstract: α-Synuclein (α-Syn) aggregation and amyloid formation is directly linked with Parkinson's disease pathogenesis. However, the early events involved in this process remain unclear. Here, using the in vitro reconstitution and cellular model, we show that liquid-liquid phase separation of α-Syn precedes its aggregation. In particular, in vitro generated α-Syn liquid-like droplets eventually undergo a liquid-to-solid transition and form an amyloid hydrogel that contains oligomers and fibrillar species. Factors known to aggravate α-Syn aggregation, such as low pH, phosphomimetic substitution and familial Parkinson's disease mutations, also promote α-Syn liquid-liquid phase separation and its subsequent maturation. We further demonstrate α-Syn liquid-droplet formation in cells. These cellular α-Syn droplets eventually transform into perinuclear aggresomes, the process regulated by microtubules. This work provides detailed insights into the phase-separation behaviour of natively unstructured α-Syn and its conversion to a disease-associated aggregated state, which is highly relevant in Parkinson's disease pathogenesis.

337 citations


Journal ArticleDOI
Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam, Federico Ambrogi  +2248 moreInstitutions (155)
TL;DR: For the first time, predictions from pythia8 obtained with tunes based on NLO or NNLO PDFs are shown to reliably describe minimum-bias and underlying-event data with a similar level of agreement to predictions from tunes using LO PDF sets.
Abstract: New sets of CMS underlying-event parameters (“tunes”) are presented for the pythia8 event generator. These tunes use the NNPDF3.1 parton distribution functions (PDFs) at leading (LO), next-to-leading (NLO), or next-to-next-to-leading (NNLO) orders in perturbative quantum chromodynamics, and the strong coupling evolution at LO or NLO. Measurements of charged-particle multiplicity and transverse momentum densities at various hadron collision energies are fit simultaneously to determine the parameters of the tunes. Comparisons of the predictions of the new tunes are provided for observables sensitive to the event shapes at LEP, global underlying event, soft multiparton interactions, and double-parton scattering contributions. In addition, comparisons are made for observables measured in various specific processes, such as multijet, Drell–Yan, and top quark-antiquark pair production including jet substructure observables. The simulation of the underlying event provided by the new tunes is interfaced to a higher-order matrix-element calculation. For the first time, predictions from pythia8 obtained with tunes based on NLO or NNLO PDFs are shown to reliably describe minimum-bias and underlying-event data with a similar level of agreement to predictions from tunes using LO PDF sets.

265 citations


Journal ArticleDOI
G. Caria1, Phillip Urquijo1, Iki Adachi2, Iki Adachi3  +228 moreInstitutions (77)
TL;DR: This work constitutes the most precise measurements of R(D) and R (D^{*}) performed to date as well as the first result for R( D) based on a semileptonic tagging method.
Abstract: The experimental results on the ratios of branching fractions $\mathcal{R}(D) = {\cal B}(\bar{B} \to D \tau^- \bar{ u}_{\tau})/{\cal B}(\bar{B} \to D \ell^- \bar{ u}_{\ell})$ and $\mathcal{R}(D^*) = {\cal B}(\bar{B} \to D^* \tau^- \bar{ u}_{\tau})/{\cal B}(\bar{B} \to D^* \ell^- \bar{ u}_{\ell})$, where $\ell$ denotes an electron or a muon, show a long-standing discrepancy with the Standard Model predictions, and might hint to a violation of lepton flavor universality. We report a new simultaneous measurement of $\mathcal{R}(D)$ and $\mathcal{R}(D^*)$, based on a data sample containing $772 \times 10^6$ $B\bar{B}$ events recorded at the $\Upsilon(4S)$ resonance with the Belle detector at the KEKB $e^+ e^-$ collider. In this analysis the tag-side $B$ meson is reconstructed in a semileptonic decay mode and the signal-side $\tau$ is reconstructed in a purely leptonic decay. The measured values are $\mathcal{R}(D)= 0.307 \pm 0.037 \pm 0.016$ and $\mathcal{R}(D^*) = 0.283 \pm 0.018 \pm 0.014$, where the first uncertainties are statistical and the second are systematic. These results are in agreement with the Standard Model predictions within $0.2$, $1.1$ and $0.8$ standard deviations for $\mathcal{R}(D)$, $\mathcal{R}(D^*)$ and their combination, respectively. This work constitutes the most precise measurements of $\mathcal{R}(D)$ and $\mathcal{R}(D^*)$ performed to date as well as the first result for $\mathcal{R}(D)$ based on a semileptonic tagging method.

228 citations


Journal ArticleDOI
Juliette Alimena1, James Baker Beacham2, Martino Borsato3, Yangyang Cheng4  +213 moreInstitutions (105)
TL;DR: In this paper, the authors present a survey of the current state of LLP searches at the Large Hadron Collider (LHC) and chart a path for the development of LLP searches into the future, both in the upcoming Run 3 and at the high-luminosity LHC.
Abstract: Particles beyond the Standard Model (SM) can generically have lifetimes that are long compared to SM particles at the weak scale. When produced at experiments such as the Large Hadron Collider (LHC) at CERN, these long-lived particles (LLPs) can decay far from the interaction vertex of the primary proton–proton collision. Such LLP signatures are distinct from those of promptly decaying particles that are targeted by the majority of searches for new physics at the LHC, often requiring customized techniques to identify, for example, significantly displaced decay vertices, tracks with atypical properties, and short track segments. Given their non-standard nature, a comprehensive overview of LLP signatures at the LHC is beneficial to ensure that possible avenues of the discovery of new physics are not overlooked. Here we report on the joint work of a community of theorists and experimentalists with the ATLAS, CMS, and LHCb experiments—as well as those working on dedicated experiments such as MoEDAL, milliQan, MATHUSLA, CODEX-b, and FASER—to survey the current state of LLP searches at the LHC, and to chart a path for the development of LLP searches into the future, both in the upcoming Run 3 and at the high-luminosity LHC. The work is organized around the current and future potential capabilities of LHC experiments to generally discover new LLPs, and takes a signature-based approach to surveying classes of models that give rise to LLPs rather than emphasizing any particular theory motivation. We develop a set of simplified models; assess the coverage of current searches; document known, often unexpected backgrounds; explore the capabilities of proposed detector upgrades; provide recommendations for the presentation of search results; and look towards the newest frontiers, namely high-multiplicity 'dark showers', highlighting opportunities for expanding the LHC reach for these signals.

Journal ArticleDOI
TL;DR: In this paper, it was shown that the correlators of the world-sheet theory are delta-function-localised in string moduli space to those configurations that allow for a holomorphic covering map of the S2-boundary of AdS3 by the world sheet.
Abstract: It was recently argued that string theory on AdS3 × S3 × 𝕋4 with one unit (k = 1) of NS-NS flux is exactly dual to the symmetric orbifold CFT SymN (𝕋4). In this paper we show how to directly relate the n-point correlators of the two sides to one another. In particular, we argue that the correlators of the world-sheet theory are delta-function- localised in string moduli space to those configurations that allow for a holomorphic covering map of the S2-boundary of AdS3 by the world-sheet. This striking feature can be seen both from a careful Ward identity analysis, as well as from semi-classically exact AdS3 solutions that are pinned to the boundary. The world-sheet correlators therefore have exactly the same structure as in the Lunin-Mathur construction of symmetric orbifold CFT correlators in terms of a covering surface — which now gets identified with the world-sheet. Together with the results of [1, 2] this essentially demonstrates how the k = 1 AdS3 string theory becomes equivalent to the spacetime orbifold CFT in the genus expansion.

Journal ArticleDOI
B. P. Abbott1, Richard J. Abbott1, T. D. Abbott2, Sheelu Abraham3  +1162 moreInstitutions (135)
TL;DR: The LIGO Scientific Collaboration and the Virgo Collaboration have cataloged eleven confidently detected gravitational-wave events during the first two observing runs of the advanced detector era as discussed by the authors.
Abstract: The LIGO Scientific Collaboration and the Virgo Collaboration have cataloged eleven confidently detected gravitational-wave events during the first two observing runs of the advanced detector era. All eleven events were consistent with being from well-modeled mergers between compact stellar-mass objects: black holes or neutron stars. The data around the time of each of these events have been made publicly available through the gravitational-wave open science center. The entirety of the gravitational-wave strain data from the first and second observing runs have also now been made publicly available. There is considerable interest among the broad scientific community in understanding the data and methods used in the analyses. In this paper, we provide an overview of the detector noise properties and the data analysis techniques used to detect gravitational-wave signals and infer the source properties. We describe some of the checks that are performed to validate the analyses and results from the observations of gravitational-wave events. We also address concerns that have been raised about various properties of LIGO–Virgo detector noise and the correctness of our analyses as applied to the resulting data.

Journal ArticleDOI
E. Kou, Phillip Urquijo1, Wolfgang Altmannshofer2, F. Beaujean3  +558 moreInstitutions (137)
TL;DR: In the original version of this manuscript, an error was introduced on pp352. '2.7nb:1.6nb' has been corrected to ''2.4nb: 1.3nb'' in the current online and printed version.
Abstract: In the original version of this manuscript, an error was introduced on pp352. '2.7nb:1.6nb' has been corrected to '2.4nb:1.3nb' in the current online and printed version. doi:10.1093/ptep/ptz106.

Posted ContentDOI
Valentina Parma1, Kathrin Ohla2, Maria G. Veldhuizen3, Masha Y. Niv4, Christine E. Kelly, Alyssa J. Bakke5, Keiland W. Cooper6, Cédric Bouysset7, Nicola Pirastu8, Michele Dibattista9, Rishemjit Kaur10, Marco Tullio Liuzza11, Marta Yanina Pepino12, Veronika Schöpf13, Veronica Pereda-Loth14, Shannon B. Olsson15, Richard C. Gerkin16, Paloma Rohlfs Domínguez17, Javier Albayay18, Michael C. Farruggia19, Surabhi Bhutani20, Alexander Fjaeldstad21, Ritesh Kumar22, Anna Menini23, Moustafa Bensafi24, Mari Sandell25, Iordanis Konstantinidis, Antonella Di Pizio26, Federica Genovese27, Lina Öztürk3, Thierry Thomas-Danguin, Johannes Frasnelli28, Sanne Boesveldt29, Ozlem Saatci, Luis R. Saraiva, Cailu Lin27, Jérôme Golebiowski7, Liang-Dar Hwang30, Mehmet Hakan Ozdener27, M.D. Guàrdia, Christophe Laudamiel, Marina Ritchie6, Jan Havlíček31, Denis Pierron14, Eugeni Roura30, Marta Navarro30, Alissa A. Nolden32, Juyun Lim33, Katherine L. Whitcroft, Lauren R. Colquitt27, Camille Ferdenzi24, Evelyn V. Brindha34, Aytug Altundag, Alberto Macchi, Alexia Nunez-Parra35, Zara M. Patel36, Sébastien Fiorucci7, Carl Philpott37, Barry C. Smith38, Johan N. Lundström39, Carla Mucignat18, Jane K. Parker40, Mirjam van den Brink41, Michael Schmuker22, Florian Ph. S. Fischmeister42, Thomas Heinbockel43, Vonnie D. C. Shields44, Farhoud Faraji45, Enrique Santamaría, William E.A. Fredborg46, Gabriella Morini47, Jonas Olofsson46, Maryam Jalessi48, Noam Karni49, Anna D'Errico50, Rafieh Alizadeh48, Robert Pellegrino51, Pablo Meyer52, Caroline Huart53, Ben Chen54, Graciela M. Soler, Mohammed K. Alwashahi55, Olagunju Abdulrahman56, Antje Welge-Lüssen57, Pamela Dalton27, Jessica Freiherr58, Carol H. Yan45, Jasper H. B. de Groot59, Vera V. Voznessenskaya, Hadar Klein4, Jingguo Chen60, Masako Okamoto61, Elizabeth Sell62, Preet Bano Singh63, Julie Walsh-Messinger64, Nicholas Archer65, Sachiko Koyama66, Vincent Deary67, S. Craig Roberts68, Huseyin Yanik3, Samet Albayrak69, Lenka Martinec Novákov31, Ilja Croijmans59, Patricia Portillo Mazal70, Shima T. Moein, Eitan Margulis4, Coralie Mignot, Sajidxa Mariño, Dejan Georgiev71, Pavan Kumar Kaushik72, Bettina Malnic73, Hong Wang27, Shima Seyed-Allaei, Nur Yoluk3, Sara Razzaghi74, Jeb M. Justice75, Diego Restrepo76, Julien W. Hsieh77, Danielle R. Reed27, Thomas Hummel78, Steven D. Munger75, John E. Hayes5 
Temple University1, Forschungszentrum Jülich2, Mersin University3, Hebrew University of Jerusalem4, Pennsylvania State University5, University of California, Irvine6, Centre national de la recherche scientifique7, University of Edinburgh8, University of Bari9, Central Scientific Instruments Organisation10, Magna Græcia University11, University of Illinois at Urbana–Champaign12, Medical University of Vienna13, University of Toulouse14, National Centre for Biological Sciences15, Arizona State University16, University of Extremadura17, University of Padua18, Yale University19, San Diego State University20, Aarhus University21, University of Hertfordshire22, International School for Advanced Studies23, French Institute of Health and Medical Research24, University of Helsinki25, Technische Universität München26, Monell Chemical Senses Center27, Université du Québec à Trois-Rivières28, Wageningen University and Research Centre29, University of Queensland30, Charles University in Prague31, University of Massachusetts Amherst32, Oregon State University33, Karunya University34, University of Chile35, Stanford University36, University of East Anglia37, University of London38, Karolinska Institutet39, University of Reading40, Maastricht University41, University of Graz42, Howard University43, Towson University44, University of California, San Diego45, Stockholm University46, University of Gastronomic Sciences47, Iran University of Medical Sciences48, Hadassah Medical Center49, Goethe University Frankfurt50, University of Tennessee51, IBM52, Cliniques Universitaires Saint-Luc53, Guangzhou Medical University54, Sultan Qaboos University55, Federal University of Technology Akure56, University Hospital of Basel57, University of Erlangen-Nuremberg58, Utrecht University59, Xi'an Jiaotong University60, University of Tokyo61, University of Pennsylvania62, University of Oslo63, University of Dayton64, Commonwealth Scientific and Industrial Research Organisation65, Indiana University66, Northumbria University67, University of Stirling68, Middle East Technical University69, Hospital Italiano de Buenos Aires70, Ljubljana University Medical Centre71, Tata Institute of Fundamental Research72, University of São Paulo73, Bilkent University74, University of Florida75, Anschutz Medical Campus76, Geneva College77, Dresden University of Technology78
24 May 2020-medRxiv
TL;DR: The results show that COVID-19-associated chemosensory impairment is not limited to smell, but also affects taste and chemesthesis, and suggest that SARS-CoV-2 infection may disrupt sensory-neural mechanisms.
Abstract: Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, generally lacked quantitative measurements, were mostly restricted to data from single countries. Here, we report the development, implementation and initial results of a multi-lingual, international questionnaire to assess self-reported quantity and quality of perception in three distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, 8 other, ages 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change+/-100) revealed a mean reduction of smell (-79.7+/- 28.7, mean+/- SD), taste (-69.0+/- 32.6), and chemesthetic (-37.3+/- 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell, but also affects taste and chemesthesis. The multimodal impact of COVID-19 and lack of perceived nasal obstruction suggest that SARS-CoV-2 infection may disrupt sensory-neural mechanisms.

Journal ArticleDOI
TL;DR: A comprehensive study of the detectability of primordial black holes with non-negligible spin, via the searches for the neutrinos and positrons in the MeV energy range, finds that spin-a fundamental property that has a strong effect on its evaporation rate, is found.
Abstract: Primordial black holes can have substantial spin---a fundamental property that has a strong effect on its evaporation rate. We conduct a comprehensive study of the detectability of primordial black holes with non-negligible spin, via the searches for the neutrinos and positrons in the MeV energy range. Diffuse supernova neutrino background searches and observation of the 511 keV gamma-ray line from positrons in the Galactic center set competitive constraints. Spinning primordial black holes are probed up to a slightly higher mass range compared to nonspinning ones. Our constraint using neutrinos is slightly weaker than that due to the diffuse gamma-ray background, but complementary and robust. Our positron constraints are typically weaker in the lower mass range and stronger in the higher mass range for the spinning primordial black holes compared to the nonspinning ones. They are generally stronger than those derived from the diffuse gamma-ray measurements for primordial black holes having masses greater than a few $\ifmmode\times\else\texttimes\fi{}{10}^{16}\text{ }\text{ }\mathrm{g}$.

Journal ArticleDOI
Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam, Federico Ambrogi  +2296 moreInstitutions (171)
TL;DR: In this article, a measurement of the mass of the Higgs boson in the diphoton decay channel is presented, based on 35.9 fb − 1 of proton-proton collision data collected during the 2016 LHC running period, with the CMS detector at a centre-of-mass energy of 13TeV.

Journal ArticleDOI
TL;DR: Long term air-stability and facile single contact metal fabrication process make the multi-functional few-layer WSe2/ReS2 heterostructure diode technologically promising for next-generation optoelectronics.
Abstract: Pn heterojunctions comprising layered van der Waals (vdW) semiconductors have been used to demonstrate current-rectifiers, photodetectors, and photovoltaic devices. However, a direct or near-direct...

Journal ArticleDOI
TL;DR: Double perovskites have recently emerged as possible alternatives to lead-based halide perovsites for photovoltaic applications as mentioned in this paper, and Cs2AgBiBr6 has been the subject of several studies.
Abstract: Double perovskites have recently emerged as possible alternatives to lead-based halide perovskites for photovoltaic applications. In particular, Cs2AgBiBr6 has been the subject of several studies b...


Posted Content
TL;DR: In this paper, it was shown that a copy of all the information on a Cauchy slice is also available near the boundary of the slice, leading to the information paradox.
Abstract: We review recent progress on the information paradox. We explain why exponentially small correlations in the radiation emitted by a black hole are sufficient to resolve the original paradox put forward by Hawking. We then describe a refinement of the paradox that makes essential reference to the black-hole interior. This analysis leads to a broadly-applicable physical principle: in a theory of quantum gravity, a copy of all the information on a Cauchy slice is also available near the boundary of the slice. This principle can be made precise and established -- under weak assumptions, and using only low-energy techniques -- in asymptotically global AdS and in four dimensional asymptotically flat spacetime. When applied to black holes, this principle tells us that the exterior of the black hole always retains a complete copy of the information in the interior. We show that accounting for this redundancy provides a resolution of the information paradox for evaporating black holes and, conversely, that ignoring this redundancy leads to paradoxes even in the absence of black holes. We relate this perspective to recent computations of the Page curve for holographic CFTs coupled to nongravitational baths. But we argue that such models may provide an inaccurate picture of the rate at which information can be extracted from evaporating black holes in asymptotically flat space. We discuss large black holes dual to typical states in AdS/CFT and the new paradoxes that arise in this setting. These paradoxes also extend to the eternal black hole. They can be resolved by assuming that the map between the boundary CFT and the black-hole interior is state dependent. We discuss the consistency of state-dependent bulk reconstructions. We conclude by examining the viability of arguments for firewalls, fuzzballs and other kinds of structure at the horizon.

Journal ArticleDOI
B. P. Abbott1, Richard J. Abbott1, T. D. Abbott2, Sheelu Abraham3  +1277 moreInstitutions (142)
TL;DR: In this paper, the authors perform Bayesian model selection on a wide range of theoretical predictions for the neutron star equation of state, and find that all scenarios from prompt collapse to long-lived or even stable remnants are possible.
Abstract: GW170817 is the very first observation of gravitational waves originating from the coalescence of two compact objects in the mass range of neutron stars, accompanied by electromagnetic counterparts, and offers an opportunity to directly probe the internal structure of neutron stars. We perform Bayesian model selection on a wide range of theoretical predictions for the neutron star equation of state. For the binary neutron star hypothesis, we find that we cannot rule out the majority of theoretical models considered. In addition, the gravitational-wave data alone does not rule out the possibility that one or both objects were low-mass black holes. We discuss the possible outcomes in the case of a binary neutron star merger, finding that all scenarios from prompt collapse to long-lived or even stable remnants are possible. For long-lived remnants, we place an upper limit of 1.9 kHz on the rotation rate. If a black hole was formed any time after merger and the coalescing stars were slowly rotating, then the maximum baryonic mass of non-rotating neutron stars is at most 3.05M⊙, and three equations of state considered here can be ruled out. We obtain a tighter limit of 2.67M⊙ for the case that the merger results in a hypermassive neutron star.

Journal ArticleDOI
TL;DR: In this article, the authors explore the formation of BHs with masses within or above the pair-instability gap through collisions of young massive stars in dense star clusters, and show that these BH-s readily go on to merge with other massive stars, creating a population of massive BH mergers at a rate that may compete with the "multiple-generation" merger channel described in other analyses.
Abstract: Theoretical modeling of massive stars predicts a gap in the black hole (BH) mass function above ~40–50 M_⊙ for BHs formed through single star evolution, arising from (pulsational) pair-instability supernovae (PISNe). However, in dense star clusters, dynamical channels may exist that allow construction of BHs with masses in excess of those allowed from single star evolution. The detection of BHs in this so-called "upper-mass gap" would provide strong evidence for the dynamical processing of BHs prior to their eventual merger. Here, we explore in detail the formation of BHs with masses within or above the pair-instability gap through collisions of young massive stars in dense star clusters. We run a suite of 68 independent cluster simulations, exploring a variety of physical assumptions pertaining to growth through stellar collisions, including primordial cluster mass segregation and the efficiency of envelope stripping during collisions. We find that as many as ~20% of all BH progenitors undergo one or more collisions prior to stellar collapse and up to ~1% of all BHs reside within or above the pair-instability gap through the effects of these collisions. We show that these BHs readily go on to merge with other BHs in the cluster, creating a population of massive BH mergers at a rate that may compete with the "multiple-generation" merger channel described in other analyses. This has clear relevance for the formation of very massive BH binaries as recently detected by the Laser Interferometer Gravitational-Wave Observatory/Virgo in GW190521. Finally, we describe how stellar collisions in clusters may provide a unique pathway to PISNe and briefly discuss the expected rate of these events and other electromagnetic transients.

Journal ArticleDOI
TL;DR: In this article, the authors used high-resolution cosmological radiative transfer simulations in large volumes to simulate a long absorption trough in the Ly$\alpha$ forest and found that the troughs are caused by islands of neutral hydrogen.
Abstract: A long (110 cMpc/$h$) and deep absorption trough in the Ly$\alpha$ forest has been observed extending down to redshift 5.5 in the spectrum of ULAS J0148+0600. Although no Ly$\alpha$ transmission is detected, Ly$\beta$ spikes are present which has led to claims that the gas along this trough must be ionized. Using high resolution cosmological radiative transfer simulations in large volumes, we show that in a scenario where reionization ends late ($z \sim 5.2$), our simulations can reproduce troughs as long as observed. In this model, we find that the troughs are caused by islands of neutral hydrogen. Small ionized holes within the neutral islands allow for the transmission of Ly$\beta$. We have also modelled the Ly$\alpha$ emitter population around the simulated troughs, and show that there is a deficit of Ly$\alpha$ emitters close to the trough as is observed.

Journal ArticleDOI
Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam, Federico Ambrogi  +2292 moreInstitutions (165)
TL;DR: The standard model (SM) production of four top quarks in proton-proton collisions is studied by the CMS Collaboration, with limits set on the production of a heavy scalar or pseudoscalar boson in Type-II two-Higgs-doublet and simplified dark matter models.
Abstract: The standard model (SM) production of four top quarks ($\text {t} {}{\overline{\text {t}}} \text {t} {}{\overline{\text {t}}} $) in proton–proton collisions is studied by the CMS Collaboration. The data sample, collected during the 2016–2018 data taking of the LHC, corresponds to an integrated luminosity of 137$\,\text {fb}^{-1}$ at a center-of-mass energy of 13$\,\text {TeV}$. The events are required to contain two same-sign charged leptons (electrons or muons) or at least three leptons, and jets. The observed and expected significances for the $\text {t} {}{\overline{\text {t}}} \text {t} {}{\overline{\text {t}}} $ signal are respectively 2.6 and 2.7 standard deviations, and the $\text {t} {}{\overline{\text {t}}} \text {t} {}{\overline{\text {t}}} $ cross section is measured to be $12.6^{+5.8}_{-5.2}\,\text {fb} $. The results are used to constrain the Yukawa coupling of the top quark to the Higgs boson, $y_{\text {t}}$, yielding a limit of $|y_{\text {t}}/y_{\text {t}}^{\mathrm {SM}} | < 1.7$ at $95\%$ confidence level, where $y_{\text {t}}^{\mathrm {SM}}$ is the SM value of $y_{\text {t}}$. They are also used to constrain the oblique parameter of the Higgs boson in an effective field theory framework, $\hat{H}<0.12$. Limits are set on the production of a heavy scalar or pseudoscalar boson in Type-II two-Higgs-doublet and simplified dark matter models, with exclusion limits reaching 350–470$\,\text {GeV}$ and 350–550$\,\text {GeV}$ for scalar and pseudoscalar bosons, respectively. Upper bounds are also set on couplings of the top quark to new light particles.

Journal ArticleDOI
TL;DR: The results identify neuronal activity as a critical target of early-life stress and demonstrate its function in controlling both postnatal oligodendrogenesis and adult mPFC-related behaviours.
Abstract: Exposure to stress during early life (infancy/childhood) has long-term effects on the structure and function of the prefrontal cortex (PFC), and increases the risk for adult depression and anxiety disorders. However, little is known about the molecular and cellular mechanisms of these effects. Here, we focused on changes induced by chronic maternal separation during the first 2 weeks of postnatal life. Unbiased mRNA expression profiling in the medial PFC (mPFC) of maternally separated (MS) pups identified an increased expression of myelin-related genes and a decreased expression of immediate early genes. Oligodendrocyte lineage markers and birthdating experiments indicated a precocious oligodendrocyte differentiation in the mPFC at P15, leading to a depletion of the oligodendrocyte progenitor pool in MS adults. We tested the role of neuronal activity in oligodendrogenesis, using designed receptors exclusively activated by designed drugs (DREADDs) techniques. hM4Di or hM3Dq constructs were transfected into mPFC neurons using fast-acting AAV8 viruses. Reduction of mPFC neuron excitability during the first 2 postnatal weeks caused a premature differentiation of oligodendrocytes similar to the MS pups, while chemogenetic activation normalised it in the MS animals. Bidirectional manipulation of neuron excitability in the mPFC during the P2–P14 period had long lasting effects on adult emotional behaviours and on temporal object recognition: hM4Di mimicked MS effects, while hM3Dq prevented the pro-depressive effects and short-term memory impairment of MS. Thus, our results identify neuronal activity as a critical target of early-life stress and demonstrate its function in controlling both postnatal oligodendrogenesis and adult mPFC-related behaviours.

Journal ArticleDOI
TL;DR: In this article, the authors used the angular moments of the energy-integrated electron lepton number distribution up to second order to track the fast neutrino flavor conversion near the collapsed stellar core.
Abstract: It has been speculated for a long time that neutrinos from a supernova (SN) may undergo fast flavor conversions near the collapsed stellar core. We perform a detailed study of this intriguing possibility, for the first time analyzing two time-dependent state-of-the-art three-dimensional (3D) SN models of $9{M}_{\ensuremath{\bigodot}}$ and $20\text{ }{M}_{\ensuremath{\bigodot}}$ from recent papers of Glas et al. Both models were computed with multidimensional three-flavor neutrino transport based on a two-moment solver, and both exhibit the presence of the so-called lepton-number emission self-sustained asymmetry (LESA). The transport solution does not provide the angular distributions of the flavor-dependent neutrino fluxes, which are crucial to track the fast flavor instability. To overcome this limitation, we use a recently proposed approach based on the angular moments of the energy-integrated electron lepton-number distribution up to second order, i.e., angle-energy integrals of the difference between ${\ensuremath{ u}}_{e}$ and ${\overline{\ensuremath{ u}}}_{e}$ phase-space distributions multiplied by corresponding powers of the unit vector of the neutrino velocity. With this method we find the possibility of fast neutrino flavor instability at radii smaller than $\ensuremath{\sim}20\text{ }\text{ }\mathrm{km}$, which is well interior to the neutrinosphere where neutrinos are still in the diffusive and near-equilibrium regime. Our results confirm recent observations in a two-dimensional (2D) (axisymmetric) SN model and in 2D and 3D models with a fixed matter background, which were computed with Boltzmann neutrino transport. However, the flavor unstable locations are not isolated points as discussed previously, but thin skins surrounding volumes where ${\overline{\ensuremath{ u}}}_{e}$ are more abundant than ${\ensuremath{ u}}_{e}$. These volumes grow with time and appear first in the convective layer of the proto-neutron star (PNS), where a decreasing electron fraction and high temperatures favor the occurrence of regions with negative neutrino chemical potential. Since the electron fraction remains higher in the LESA dipole direction, where convective lepton-number transport out from the nonconvective PNS core slows down the deleptonization, flavor unstable conditions become more widespread in the opposite hemisphere. This interesting phenomenon deserves further investigation, since its impact on SN modeling and possible consequences for SN dynamics and neutrino observations are presently unclear.

Journal ArticleDOI
Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam, Federico Ambrogi  +2357 moreInstitutions (213)
TL;DR: In this article, a search for narrow and broad resonances with masses greater than 1.8 TeV decaying to a pair of jets is presented, and the results show that no significant evidence for the production of new particles is observed.
Abstract: A search for narrow and broad resonances with masses greater than 1.8 TeV decaying to a pair of jets is presented. The search uses proton-proton collision data at $ \sqrt{s} $ = 13 TeV collected at the LHC, corresponding to an integrated luminosity of 137 fb$^{−1}$. The background arising from standard model processes is predicted with the fit method used in previous publications and with a new method. The dijet invariant mass spectrum is well described by both data-driven methods, and no significant evidence for the production of new particles is observed. Model independent upper limits are reported on the production cross sections of narrow resonances, and broad resonances with widths up to 55% of the resonance mass. Limits are presented on the masses of narrow resonances from various models: string resonances, scalar diquarks, axigluons, colorons, excited quarks, color-octet scalars, W′ and Z′ bosons, Randall-Sundrum gravitons, and dark matter mediators. The limits on narrow resonances are improved by 200 to 800 GeV relative to those reported in previous CMS dijet resonance searches. The limits on dark matter mediators are presented as a function of the resonance mass and width, and on the associated coupling strength as a function of the mediator mass. These limits exclude at 95% confidence level a dark matter mediator with a mass of 1.8 TeV and width 1% of its mass or higher, up to one with a mass of 4.8 TeV and a width 45% of its mass or higher.[graphic not available: see fulltext]

Journal ArticleDOI
Enrico Barausse1, Enrico Barausse2, Emanuele Berti3, Thomas Hertog4  +323 moreInstitutions (98)
TL;DR: In this article, the future potential of the LISA mission in the area of fundamental physics was further delineated and sharpen the potential of LISA data in a broad range of topics.
Abstract: In this paper, which is of programmatic rather than quantitative nature, we aim to further delineate and sharpen the future potential of the LISA mission in the area of fundamental physics. Given the very broad range of topics that might be relevant to LISA,we present here a sample of what we view as particularly promising fundamental physics directions. We organize these directions through a “science-first” approach that allows us to classify how LISA data can inform theoretical physics in a variety of areas. For each of these theoretical physics classes, we identify the sources that are currently expected to provide the principal contribution to our knowledge, and the areas that need further development. The classification presented here should not be thought of as cast in stone, but rather as a fluid framework that is amenable to change with the flow of new insights in theoretical physics.

Journal ArticleDOI
17 Mar 2020
TL;DR: In this article, it was shown that crystalline topological phases can be materialized in non-crystalline systems and that when weak structural disorder is confined within the interior of the system, it can support amorphous higher-order topological insulators.
Abstract: This paper shows that crystalline topological phases can be materialized in noncrystalline systems. The authors use explicit computation of the corner modes and bulk multipolar invariant and find that when weak structural disorder is confined within the interior of the system it can support amorphous higher-order topological insulators