Tata Institute of Fundamental Research

About: Tata Institute of Fundamental Research is a education organization based out in Mumbai, Maharashtra, India. It is known for research contribution in the topics: Magnetization & Large Hadron Collider. The organization has 7786 authors who have published 21742 publications receiving 622368 citations. The organization is also known as: TIFR.

Development of the indirect flight muscles of Drosophila.

Abstract: We have followed the pupal development of the indirect flight muscles (IFMs) of Drosophila melanogaster. At the onset of metamorphosis larval muscles start to histolyze, with the exception of a specific set of thoracic muscles. Myoblasts surround these persisting larval muscles and begin the formation of one group of adult indirect flight muscles, the dorsal longitudinal muscles. We show that the other group of indirect flight muscles, the dorsoventral muscles, develops simultaneously but without the use of larval templates. By morphological criteria and by patterns of specific gene expression, our experiments define events in IFM development.

Structural and conformational stability of horseradish peroxidase: effect of temperature and pH.

Abstract: Detailed circular dichroism and fluorescence studies at different pHs have been carried out to monitor thermal unfolding of horseradish peroxidase isoenzyme c (HRPc). The change in CD in the 222 nm region corresponds to changes in the overall secondary structure of the enzyme, while that in the 400 nm region (Soret region) corresponds to changes in the tertiary structure around the heme in the enzyme. The temperature dependence of the tertiary structure around the heme also affected the intrinsic tryptophan fluorescence emission spectrum of the enzyme. The results suggested that melting of the tertiary structure to a pre-molten globule form takes place at 45 degrees C, which is much lower than the temperature (T(m) = 74 degrees C) at which depletion of heme from the heme cavity takes place. The melting of the tertiary structure was found to be associated with a pK(a) of approximately 5, indicating that this phase possibly involves breaking of the hydrogen-bonding network of the heme pocket, keeping the heme moiety still inside it. The stability of the secondary structure of the enzyme was also found to decrease at pH below 4.5. A 'high temperature' unfolding phase was observed which was, however, independent of pH. The stability of the secondary structure was found to drastically decrease in the presence of DTT (dithiothreitol), indicating that the 'high temperature' form is possibly stabilized due to interhelical disulfide bonds. Depletion of Ca(2+) ions resulted in a marked decrease in the stability of the secondary structure of the enzyme.

Constraining solar abundances using helioseismology

Abstract: Recent analyses of solar photospheric abundances suggest that the oxygen abundance in the solar atmosphere needs to be revised downward. In this study, we investigate the consequence of this revision on helioseismic analyses of the depth of the solar convection zone and the helium abundance in the solar envelope and find no significant effect. We also find that the revised abundances along with the current OPAL opacity tables are not consistent with seismic data. A significant upward revision of the opacity tables is required to make solar models with lower oxygen abundance consistent with seismic observations.

Conformal Nonlinear Fluid Dynamics from Gravity in Arbitrary Dimensions

Abstract: We generalize recent work to construct a map from the conformal Navier Stokes equations with holographically determined transport coefficients, in d spacetime dimensions, to the set of asymptotically locally AdSd+1 long wavelength solutions of Einstein's equations with a negative cosmological constant, for all 2$>d>2. We find simple explicit expressions for the stress tensor (slightly generalizing the recent result by Haack and Yarom (arXiv:0806.4602)), the full dual bulk metric and an entropy current of this strongly coupled conformal fluid, to second order in the derivative expansion, for arbitrary 2$>d>2. We also rewrite the well known exact solutions for rotating black holes in AdSd+1 space in a manifestly fluid dynamical form, generalizing earlier work in d = 4. To second order in the derivative expansion, this metric agrees with our general construction of the metric dual to fluid flows.