Tata Institute of Fundamental Research

About: Tata Institute of Fundamental Research is a education organization based out in Mumbai, Maharashtra, India. It is known for research contribution in the topics: Magnetization & Large Hadron Collider. The organization has 7786 authors who have published 21742 publications receiving 622368 citations. The organization is also known as: TIFR.

Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells

Abstract: Although the importance of clathrin- and caveolin-independent endocytic pathways has recently emerged, key aspects of these routes remain unknown. Using quantitative ultrastructural approaches, we show that clathrin-independent carriers (CLICs) account for approximately three times the volume internalized by the clathrin-mediated endocytic pathway, forming the major pathway involved in uptake of fluid and bulk membrane in fibroblasts. Electron tomographic analysis of the 3D morphology of the earliest carriers shows that they are multidomain organelles that form a complex sorting station as they mature. Proteomic analysis provides direct links between CLICs, cellular adhesion turnover, and migration. Consistent with this, CLIC-mediated endocytosis of key cargo proteins, CD44 and Thy-1, is polarized at the leading edge of migrating fibroblasts, while transient ablation of CLICs impairs their ability to migrate. These studies provide the first quantitative ultrastructural analysis and molecular characterization of the major endocytic pathway in fibroblasts, a pathway that provides rapid membrane turnover at the leading edge of migrating cells.

A Higgs in the Warped Bulk and LHC signals

Abstract: Warped models with the Higgs in the bulk can generate light Kaluza-Klein (KK) Higgs modes consistent with the electroweak precision analysis. The first KK mode of the Higgs (h 1) could lie in the 1-2 TeV range in the models with a bulk custodial symmetry. We find that the h 1 is gaugephobic and decays dominantly into a $$ t\overline{t} $$ pair. We also discuss the search strategy for h 1 decaying to $$ t\overline{t} $$ at the Large Hadron Collider. We used substructure tools to suppress the large QCD background associated with this channel. We find that h 1 can be probed at the LHC run-2 with an integrated luminosity of 300 fb−1.

Effects of nematic fluctuations on the elastic properties of iron arsenide superconductors.

Abstract: We demonstrate that the changes in the elastic properties of the FeAs systems, as seen in our resonant ultrasound spectroscopy data, can be naturally understood in terms of fluctuations of emerging nematic degrees of freedom. Both the softening of the lattice in the normal, tetragonal phase as well as its hardening in the superconducting phase are consistently described by our model. Our results confirm the view that structural order is induced by magnetic fluctuations.

Clusters, asters, and collective oscillations in chemotactic colloids.

Abstract: The creation of synthetic systems that emulate the defining properties of living matter, such as motility, gradient-sensing, signaling, and replication, is a grand challenge of biomimetics. Such imitations of life crucially contain active components that transform chemical energy into directed motion. These artificial realizations of motility point in the direction of a new paradigm in engineering, through the design of emergent behavior by manipulating properties at the scale of the individual components. Catalytic colloidal swimmers are a particularly promising example of such systems. Here we present a comprehensive theoretical description of gradient-sensing of an individual swimmer, leading controllably to chemotactic or anti-chemotactic behavior, and use it to construct a framework for studying their collective behavior. We find that both the positional and the orientational degrees of freedom of the active colloids can exhibit condensation, signaling formation of clusters and asters. The kinetics of catalysis introduces a natural control parameter for the range of the interaction mediated by the diffusing chemical species. For various regimes in parameter space in the long-ranged limit our system displays precise analogs to gravitational collapse, plasma oscillations, and electrostatic screening. We present prescriptions for how to tune the surface properties of the colloids during fabrication to achieve each type of behavior.

Search for resonances and quantum black holes using dijet mass spectra in proton-proton collisions at s =8TeV

Abstract: A search for resonances and quantum black holes is performed using the dijet mass spectra measured in proton-proton collisions at s√=8 TeV with the CMS detector at the LHC. The data set corresponds to an integrated luminosity of 19.7 fb^(−1). In a search for narrow resonances that couple to quark-quark, quark-gluon, or gluon-gluon pairs, model-independent upper limits, at 95% confidence level, are obtained on the production cross section of resonances, with masses above 1.2 TeV. When interpreted in the context of specific models the limits exclude string resonances with masses below 5.0 TeV; excited quarks below 3.5 TeV; scalar diquarks below 4.7 TeV; W′ bosons below 1.9 TeV or between 2.0 and 2.2 TeV; Z′ bosons below 1.7 TeV; and Randall-Sundrum gravitons below 1.6 TeV. A separate search is conducted for narrow resonances that decay to final states including b quarks. The first exclusion limit is set for excited b quarks, with a lower mass limit between 1.2 and 1.6 TeV depending on their decay properties. Searches are also carried out for wide resonances, assuming for the first time width-to-mass ratios up to 30%, and for quantum black holes with a range of model parameters. The wide resonance search excludes axigluons and colorons with mass below 3.6 TeV, and color-octet scalars with mass below 2.5 TeV. Lower bounds between 5.0 and 6.3 TeV are set on the masses of quantum black holes.