Showing papers by "Tata Memorial Hospital published in 1981"
TL;DR: A patient with an unusual case of endodermal sinus (yolk sac) tumor arising in the vulva and presenting during pregnancy succumbed to her illness due to widespread pulmonary and pleural involvement within 11 months of onset of symptoms.
24 citations
TL;DR: Data on tumorigenicity and mutagenicity of INH show that INH is tumorigenic in mice but not in rats, and in vivo and in vitro studies on INH interaction with macromolecules reveal that there is a greater interaction with RNA than with DNA.
Abstract: Data on tumorigenicity and mutagenicity of INH show that INH is tumorigenic in mice but not in rats. The metabolic studies on the two species denote that rats are rapid inactivators whereas mice are slow inactivators of INH. Rats are also resistant to the immediate inhibitory effect of INH on DNA biosynthesis. Using Ames test it was observed that INH is mutagenic to salmonella typhimurium strains TA 100 and 1535 and this effect is abolished in presence of 59 mixture. In vivo and in vitro studies on INH interaction with macromolecules reveal that there is a greater interaction with RNA than with DNA and the site of interaction is the cytidine and deoxycytidine, respectively. A preliminary study is undertaken to see if healed TB cases have a higher risk for cancer. It is found that cancer incidence in this group is higher as compared to noncancer patients.
13 citations
TL;DR: Evidence that T-CLL, a rare variant of CLL, is an aggressive disease with relative resistance to therapy and short survival is provided.
Abstract: A case of T-cell chronic lymphocytic leukemia (T-CLL) is reported. The surface receptor for sheep erythrocytes and acid phosphatase staining confirmed the diagnosis of T-CLL. This report provides evidence that T-CLL, a rare variant of CLL, is an aggressive disease with relative resistance to therapy and short survival.
9 citations
TL;DR: Twenty patients of primary urethral carcinoma in females with vague symptoms in early stage delayed the diagnosis, and 33% three years and 21% five years survivals were noted.
Abstract: Twenty patients of primary urethral carcinoma in females are presented. Age group affected was between 40 and 60 years. Vague symptoms in early stage delayed the diagnosis in most patients. Surgery is the treatment of choice for meatal or anterior urethral lesions while combined Radiotherapy and surgery has been suggested as treatment for entire urethral lesions. In the present series 33% three years and 21% five years survivals were noted.
7 citations
TL;DR: Strong evidence is presented to suggest that methemoglobinemia is acquired in leukemia as a result of greatly increased in vivo oxidation of hemoglobin by oxidants generated by the leukemic cells, in spite of a normal Hi-reducing system in the red cells.
6 citations
TL;DR: Serum hPL was not detectable in normal or nonneoplastic conditions and its high incidence in cervical cancer patients indicate its possible use as marker in cancer of cervix.
2 citations
TL;DR: This paper analyses 66 patients during a period of 20 years who underwent thoracotomy for such solitary pulmonary lesions, and emphasizes the role of diagnostic‐cum‐therapeutic‐thoracotomy in such a clinical situation where in prethOracotomy tissue diagnosis is not forthcoming.
Abstract: Surgical resection of a solitary pulmonary metastasis is an established procedure. A medical generation ago when such a shadow appeared on chest roentgenogram of a patient who had known cancer elsewhere in body, it was assumed to be "metastasis" from an extrathoracic site. With increasing advances in knowledge, the occurrence of second primary or new lesion is now no more curiosity in clinical practice. To one's surprise, the lesions that are assumed to be metastatic have often turned out to be "fresh" lesion or even unrelated benign, granulomatous, inflammatory, or parasitic lesion. This paper analyses 66 patients during a period of 20 years who underwent thoracotomy for such solitary pulmonary lesions, and emphasizes the role of diagnostic-cum-therapeutic-thoracotomy in such a clinical situation where in prethoracotomy tissue diagnosis is not forthcoming.
2 citations