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Institution

Tata Memorial Hospital

HealthcareMumbai, India
About: Tata Memorial Hospital is a healthcare organization based out in Mumbai, India. It is known for research contribution in the topics: Cancer & Breast cancer. The organization has 3187 authors who have published 4636 publications receiving 109143 citations.


Papers
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Journal ArticleDOI
TL;DR: Induction chemotherapy was effective in converting technically unresectable oral cavity cancers to operable disease in approximately 40% of patients and was associated with significantly improved overall survival in comparison to nonsurgical treatment.
Abstract: Background: Locally advanced and unresectable oral cavity cancers have a poor prognosis. Induction might be beneficial in this setting by reducing tumor bulk and allowing definitive surgery. Aim: To analyze the impact of induction chemotherapy on locally advanced, technically unresectable oral cavity cancers. Materials and Methods: Retrospective analysis of patients with locally advanced oral cavity cancers, who were treated with neoadjuvant chemotherapy (NACT) during the period between June 2009 and December 2010. Data from a prospectively filled database were analyzed for information on patient characteristics, chemotherapy received, toxicity, response rates, local treatment offered, patterns of failure, and overall survival. The statistical analysis was performed with SPSS version 16. Results: 123 patients, with a median age of 42 years were analyzed. Buccal mucosa was the most common subsite (68.30%). Three drug regimen was utilized in 26 patients (21.10%) and the rest received two drug regimen. Resectability was achieved in 17 patients treated with 3 drug regimen (68.00%) and 36 patients receiving 2 drug regimen. Febrile neutropenia was seen in 3 patients (3.09%) receiving 2 drug regimen and in 9 patients (34.62%) receiving 3 drug regimen. The estimated median OS was not reached in patients who had clinical response and underwent surgery as opposed to 8 months in patients treated with non-surgical modality post NACT (P = 0.0001). Conclusion: Induction chemotherapy was effective in converting technically unresectable oral cavity cancers to operable disease in approximately 40% of patients and was associated with significantly improved overall survival in comparison to nonsurgical treatment.

36 citations

Journal ArticleDOI
TL;DR: Monthly palliative pelvic radiotherapy results in satisfactory control of symptoms in patients with locally advanced carcinoma of cervix with acceptable complications.
Abstract: Background: Patients with locally advanced cervical cancer are often severely distressed with incessant vaginal bleeding, offensive discharge and pelvic pain and are in some instances are beyond curative potential. At our institution we routinely use monthly palliative pelvic radiotherapy for these patients. Methods and Material: One hundred patients treated between 2000 & 2004 were included in this analysis. Patients were treated with parallel-opposed pelvic portals with megavoltage radiation monthly up to a maximum of three fractions (10Gy/ fraction). Patients with good response after second fraction were considered for intracavitary brachytherapy delivering 30Gy to point A. Response was documented with regard to relief of bleeding, vaginal discharge and pelvic pain. The other aspects evaluated were patient compliance, disease response, toxicity and survival. Results: Sixty-eight percent had FIGO stage IIIB, 12% had stage IVA and 14% had IVB disease. Twenty patients had metastatic disease. The median symptom duration was 5 months. Majority (67%) presented with vaginal bleeding, followed by discharge (69%) and pelvic pain (48%). All patients received at least one fraction of palliative pelvic radiotherapy. Sixty-one patients received the second fraction and 33 the third. Five patients received an intracavitary application. The overall response rates in terms of control of bleeding, discharge and pain were 100%, 49% and 33% respectively. The treatment was generally well tolerated with a median survival of 7 months. Conclusions: Monthly palliative pelvic radiotherapy results in satisfactory control of symptoms in patients with locally advanced carcinoma of cervix with acceptable complications.

36 citations

Journal ArticleDOI
TL;DR: The role of modern imaging modalities in investigating skeletal involvement by cancer is explored, and the significance and implications of the osseous abnormalities visualized by FDG-PET are understood.
Abstract: In this communication, we have explored the role of modern imaging modalities in investigating skeletal involvement by cancer. Obviously, detecting and characterizing disease sites at early stages are most desirable for the early and accurate assessment of disease activity. Based on the differences in physical and biological principles of each of these imaging modalities, they can be broadly categorized into two groups: those that detect the disease sites at the “bone marrow” (BM) level and those that rely on indirect evidence including osteoblastic reaction after invasion of the surrounding bone by the pathologic process. We further subclassify the first group of methodologies into two categories: those that visualize lesions as negative focal marrow defects as seen on BM scintigraphy (BMS) or MRI, and those that are based on targeting of abnormal tissue directly such as with fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging. The emergence of the latter method combined with whole-body tomographic imaging has truly revolutionized diagnosis and staging of patients with cancer and other serious disorders. This is particularly true for FDG-PET imaging, which is now commonly employed. It is imperative to understand the significance and implications of the osseous abnormalities visualized by FDG-PET as opposed to those seen by either structural (CT or MRI) or other functional imaging modalities (bone scintigraphy). Inappropriate interpretation of the results from these distinctly different types of imaging studies has resulted in misunderstanding of the optimal utility of different approaches. In this communication, we shall make an effort to clarify the underlying concepts that are related to this subject and the controversies that are reported in the literature. For years, functional imaging with bone scintigraphy has been utilized as the initial imaging modality to screen the skeleton for metastatic disease. Because of its widespread availability, low cost, relatively high sensitivity, and ability to evaluate the entire skeleton in a single examination, this technique has been quite effective in many settings. However, as the role of FDG-PET in the management of patients with cancer and other disorders is becoming well established, the role of conventional bone scintigraphy and similar imaging techniques is being questioned in this setting [1, 2]. The principles by which these modalities Eur J Nucl Med Mol Imaging (2008) 35:465–471 DOI 10.1007/s00259-007-0593-0

36 citations

Journal ArticleDOI
TL;DR: The levels of plasma cFN, determined by ELISA using the 2 antibodies, are found to be increased in G-I and H-N cancers, and an additional anti-EDA-reactive 30 kD peptide is seen in the plasma.

36 citations

Journal ArticleDOI
TL;DR: Clinical evidence of neck metastases is an independent predictor of outcome, even in patients with pN− nodes, and cN classification was associated with recurrence-free survival and locoregional (neck and primary tumor) control but not with local and distant recurrence rates.
Abstract: Background We aimed to study the importance of clinical N classification (cN) in a subgroup of patients with oral cavity squamous cell carcinoma (OSCC) and pathologically negative neck nodes (pN−).

35 citations


Authors

Showing all 3213 results

NameH-indexPapersCitations
Al B. Benson11357848364
Keitaro Matsuo9781837349
Ashish K. Jha8750330020
Noopur Raje8250627878
Muthupandian Ashokkumar7651120771
Snehal G. Patel7336716905
Rainu Kaushal5823216794
Ajit S. Puri543699948
Jasbir S. Arora5135115696
Sudeep Sarkar4827310087
Ian T. Magrath471078084
Pankaj Chaturvedi4532515871
Pradeep Kumar Gupta444167181
Shiv K. Gupta431508911
Kikkeri N. Naresh432456264
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20235
202232
2021223
2020244
2019206
2018239