Tata Memorial Hospital

About: Tata Memorial Hospital is a healthcare organization based out in Mumbai, India. It is known for research contribution in the topics: Cancer & Breast cancer. The organization has 3187 authors who have published 4636 publications receiving 109143 citations.

A Malignant Sertoli Cell Tumour of the Testis

Abstract: Summary A case of a malignant Sertoli cell tumour (androblastoma) of the testis in a Hindu male aged 33 is reported. A table summarises the features of 8 malignant Sertoli cell tumours of the testis previously recorded in the world literature. In the present case the local appearances were deceptively benign and gynaecomastia persisted after apparently satisfactory control of tumour growth.

Incremental value of 18F-FDG PET/CT in therapeutic decision-making of potentially curable esophageal adenocarcinoma.

Abstract: AIMS AND OBJECTIVES The aim of the study was to estimate the incremental value of fluorine-18 fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) in aiding treatment decisions in a specific cohort of patients with lower esophageal and gastroesophageal junction adenocarcinoma who were considered for potentially curative treatment on the basis of conventional imaging. MATERIALS AND METHODS The study included patients referred for a staging F-FDG PET/CT who were considered for potentially curative treatment (neoadjuvant therapy followed by surgery or definitive chemoradiotherapy) by a multidisciplinary tumor board. The proportion of patients with M1b disease (American Joint Committee on Cancer, 6th ed.) detected on F-FDG PET/CT was calculated. The sensitivity, specificity, positive and negative predictive values, and accuracy of F-FDG PET/CT for M1b disease were calculated. PET/CT findings were verified with histopathological analysis; when it was not possible to obtain pathological confirmation, correlative imaging or follow-up imaging studies were used for validation. RESULTS A total of 156 patients who fulfilled the inclusion criteria were analyzed. F-FDG PET/CT detected M1b disease in 25 patients (16%), changing the intent of treatment from potentially curative to palliative. In five patients, PET/CT failed to detect distant metastases. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of F-FDG PET/CT for detecting M1b disease were 83.3, 98.4, 92.5, 96.1, and 95.3%, respectively. Additional surgical procedures (hemicolectomy and polypectomy) were performed in three patients because of the detection of a second primary cancer in the colon in two patients and a colonic dysplastic polyp in one patient. CONCLUSION In patients who are considered to be potentially curable after conventional imaging, F-FDG PET/CT can detect unsuspected sites of distant metastases (M1b) in a significant number of cases and thus contribute to the clinical decision-making process. PET/CT should be an integral part of the staging workup of patients with esophageal adenocarcinoma.

Bilateral persistent hyperplastic primary vitreous.

Abstract: We report a case of bilateral persistent hyperplastic primary vitreous (PHPV) in a 5-month-old infant who presented with bilateral leukokoria. The child was referred for ocular ultrasound with a clinical suspicion of retinoblastoma. Grey-scale evaluation revealed an echogenic band in the posterior segment of the left globe extending from the posterior surface of the lens capsule to the optic disc. Doppler examination revealed the presence of blood flow in the band. Ultrasound assessment of the contralateral globe showed an elevated mass of echogenic tissue in the posterior segment, in contact with the optic disc. Most cases of PHPV are sporadic and unilateral. Bilateral PHPV is rare. In a study by Pollard of 83 cases, only two patients (2.4%) had bilateral PHPV. The imaging features in this case point toward the diagnosis of bilateral PHPV. We suggest that this entity, although rare, should be considered in the differential diagnosis while evaluating bilateral leukokoria.