scispace - formally typeset
Search or ask a question
Institution

Tata Memorial Hospital

HealthcareMumbai, India
About: Tata Memorial Hospital is a healthcare organization based out in Mumbai, India. It is known for research contribution in the topics: Cancer & Breast cancer. The organization has 3187 authors who have published 4636 publications receiving 109143 citations.


Papers
More filters
Proceedings ArticleDOI
22 Aug 2009
TL;DR: A CAOS system called OrthoSYS is developed, driven by geometric reasoning algorithms to visualize tumor size, shape, and plan for resection according to the tumor's spread, starting from a 3D model reconstructed from CT images.
Abstract: Computer Assisted Orthopedic Surgery (CAOS) employing information and computer graphics technologies for preoperative planning, intraoperative navigation, and for guiding or performing surgical interventions, has received very little attention for bone tumor surgery applications. We have developed a CAOS system called OrthoSYS, driven by geometric reasoning algorithms to visualize tumor size, shape, and plan for resection according to the tumor's spread, starting from a 3D model reconstructed from CT images. Anatomical landmarks on bone are automatically identified and labeled, useful for registering patient model with virtual model during surgery and also as a reference for tumor resection and prosthesis positioning. The thickness of bone stock remaining after tumor resection is automatically analyzed to choose the best modular stem and fix the prosthesis. A method for prosthesis components selection using fuzzy logic has been developed to assist the surgeons. The medial axis of the long bones and anatomical landmarks are used for positioning the prosthesis in virtual planning and verification in the intraoperative stage. A set of anatomical metrics have been developed to measure the effectiveness of the prosthetic replacement of bone.

51 citations

Journal ArticleDOI
TL;DR: Findings indicate that a combination of cytotoxic agents and IGF-1R inhibitor is more effective at early stages of chemoresistant ovarian cancer.

51 citations

Journal ArticleDOI
TL;DR: The study indicated that blood vessel invasion in the primary breast carcinoma is more significant than lymph node metastasis.
Abstract: Prognostic significance of blood vessel invasion in carcinoma of the female breast has been evaluated by study of 242 cases of radical mastectomy done at the Tata Memorial Hospital. The significance of axillary node involvement with the disease has been simultaneously evaluated. In the absence of blood vessel invasion and lymph node metastasis the 5 year survival rate was 98%. Compared with this, 5 year survival rate was reduced to 59% when the blood vessel invasion was present but no lymph node metastasis. Only 12% survived for 5 years when both blood vessels and lymph nodes were involved with the disease. The study indicated that blood vessel invasion in the primary breast carcinoma is more significant than lymph node metastasis.

51 citations

Journal Article
TL;DR: SGA is a simple and inexpensive way to identify clinically relevant malnutrition in Indian patients undergoing cancer surgery, and its use for nutritional screening is likely to overestimate severe malnutrition in Indians.
Abstract: Background and Aims: Subjective global assessment (SGA) is a simple and reliable malnutritionscreening tool. The SGA has not been evaluated in India or in populations where chronic energy deficiency (CED) is rampant. We evaluated the value of preoperative nutrition, determined using the SGA, in predicting postoperative adverse outcomes in cancer patients. Methods: Two hundred and ninetyfour cancer patients undergoing elective surgery were screened for malnutrition using a modified version of the SGA, and 266 patients (aged 14-73 years [median 50]; 165 male) were eligible. All patients were followed up till discharge, and number of days on antibiotics, length of postoperative stay, occurrence of major adverse events, and death within 30 days were recorded. The association of preoperative SGA scores (A, B, or C) and BMI groups ( 20 Kg/m 2 ) and four outcome variables were tested for statistical significance. Results: The cancer sites included head and neck region in 112, gastrointestinal tract in 53, thoracic organs in 28, and other sites in 73 patients. The SGA scores were A in 152, B in 98, and C in 16 patients. The BMI was <18.5 in 110 (41.8%) patients. The length of postoperative stay and the number of antibiotic days revealed a significant trend from SGA-A to SGA-C (p=0.000). Pre-defined adverse events occurred in 7.9%, 17.3% and 25% of SGA groups A, B, and C, respectively (p=0.025). The risk for adverse events was significantly higher in SGA-C group (OR 5.27, 95% CI 1.35-20.51, p<0.016) compared to SGA-A group. Three patients in SGA-B group and one in SGA-C group died within 30 days (p=0.04). No significant association was detected between the three BMI groups and duration of antibiotic use, length of postoperative stay, adverse events or mortality. Conclusion: SGA is a simple and inexpensive way to identify clinically relevant malnutrition in Indian patients undergoing cancer surgery. Low BMI was not associated with postoperative adverse outcomes, and its use for nutritional screening is likely to overestimate severe malnutrition in Indian patients. [Indian J Gastroenterol

51 citations

Journal ArticleDOI
TL;DR: It can be concluded that at 9 months after surgery both therapies resulted in significant PD reductions and CAL gains and significant improvement was seen in bone fill and percentage gain with both the material, however, there was no significant difference between both.
Abstract: The purpose of the present study was to clinically and radiographically evaluate and compare the efficacy of demineralized freeze dried bone allograft (DFDBA) and bovine derived xenogenic bone graft (BDX) [Bio-Oss] with amniotic membrane (AM) as guided tissue regeneration (GTR) in the treatment of human periodontal Grade II buccal furcation defects. Ten patients suffering from chronic periodontitis, displaying bilateral Grade II buccal furcation defect, were randomly treated using DFDBA with AM (Experimental site A) or using bovine derived xenograft (BDX) with AM (Experimental site B). The clinical and radiographic parameters were recorded at baseline, 6 and 9 months. Healing was uneventful in all patients except one site which was treated with BDX + AM. At 9 months after therapy, soft tissue measurements for the DFDBA + AM group showed pocket depth (PD) reduction of 4.7 mm ± 0.58, and relative attachment level gain of 4.8 mm + 0.32, while the BDX + AM group showed a PD reduction of 4.4 mm ± 0.27, and AL gain of 5.1 mm ± 0.09. Osseous measurements showed bone fill of 2.1 mm ± 0.36 for the DFDBA + AM group and 2.43 mm ± 0.38 for the BDX + AM group. Percentage gain in bone was 76.3% for the DFDBA + AM group and 79.6% for the BDX + AM group. Statistical analysis revealed there was no statistical difference between the two materials in all measurements. Within the limits of the present study, it can be concluded that: (1) at 9 months after surgery both therapies resulted in significant PD reductions and CAL gains and (2) significant improvement was seen in bone fill and percentage gain with both the material, however, there was no significant difference between both.

51 citations


Authors

Showing all 3213 results

NameH-indexPapersCitations
Al B. Benson11357848364
Keitaro Matsuo9781837349
Ashish K. Jha8750330020
Noopur Raje8250627878
Muthupandian Ashokkumar7651120771
Snehal G. Patel7336716905
Rainu Kaushal5823216794
Ajit S. Puri543699948
Jasbir S. Arora5135115696
Sudeep Sarkar4827310087
Ian T. Magrath471078084
Pankaj Chaturvedi4532515871
Pradeep Kumar Gupta444167181
Shiv K. Gupta431508911
Kikkeri N. Naresh432456264
Network Information
Related Institutions (5)
All India Institute of Medical Sciences
40.1K papers, 640.4K citations

91% related

The Royal Marsden NHS Foundation Trust
13.4K papers, 668.8K citations

87% related

Memorial Sloan Kettering Cancer Center
65.3K papers, 4.4M citations

85% related

University of Texas MD Anderson Cancer Center
92.5K papers, 4.7M citations

85% related

Peter MacCallum Cancer Centre
9.8K papers, 458.8K citations

84% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20235
202232
2021223
2020244
2019206
2018239