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Institution

Technical University of Berlin

EducationBerlin, Germany
About: Technical University of Berlin is a education organization based out in Berlin, Germany. It is known for research contribution in the topics: Quantum dot & Laser. The organization has 27292 authors who have published 59342 publications receiving 1414623 citations. The organization is also known as: Technische Universität Berlin & TU Berlin.


Papers
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Journal ArticleDOI

216 citations

Journal ArticleDOI
TL;DR: This review outlines the connection between zinc and immunity by giving a survey on the major roles of zinc in immune cell function, and their potential consequences in vivo.

216 citations

Journal ArticleDOI
TL;DR: The effect of silicon on manganese tolerance of bean plants (Phaseolus vulgaris L var ‘Red Kidney’) grown in water culture was studied at different levels of manganous supply.
Abstract: The effect of silicon on manganese tolerance of bean plants (Phaseolus vulgaris L var ‘Red Kidney’) grown in water culture was studied at different levels of manganese supply Without silicon, growth depression and toxicity symptoms occurred already at 5 × 10−4 mM Mn in the nutrient solution After addition of Aerosil (075 ppm Si), the plants tolerated 5 × 10−3 mM Mn and, at a higher silicon supply of 40 ppm, as much as 10−2 mM Mn in the nutrient solution without any growth depression This increase in manganese tolerance was not caused by a depressing effect of silicon on uptake or translocation of manganese but rather by an increase in the manganese tolerance of the leaf tissue In absence of silicon, 100 ppm Mn was already toxic for the leaf tissue, whereas with a supply of 40 ppm Si, this ‘critical level’ in the leaves was increased to more than 1000 ppm Mn At lower manganese levels in the leaf tissue, a molar ratio Si/Mn of 6 within the tissue was sufficient to prevent manganese toxicity Above 1000 ppm Mn, however, even a much wider Si/Mn ratio (> 20) could not prevent growth depression by manganese toxicity With54Mn and autoradiographic studies, it could be demonstrated that, in absence of silicon, even at optimal manganese supply (10−4 mM), the distribution of manganese within the leaf blades was inhomogeneous and characterized by spot-like accumulations In presence of silicon, however, the manganese distribution was homogeneous in the lower concentration range of manganese and still fairly homogeneous in the high concentration range This effect of silicon on manganese distribution on the tissue level was also reflected on the cellular level In the presence of silicon, a higher proportion of the leaf manganese could be found in the press sap,ie, had been transported into the vacuoles, than in the absence of silicon The increase in manganese tolerance of bean leaves by silicon therefore seems to be primarily caused by the prevention of local manganese accumulation within the leaf tissue which leads to local disorders of the metabolism and, correspondingly, growth depression

216 citations

Journal ArticleDOI
TL;DR: A new method to directly monitor mechanotransduction at defined regions of the cell-substrate interface is developed and it is shown that molecular-scale (~13 nm) displacements are sufficient to gate mechanosensitive currents in mouse touch receptors.
Abstract: In sensory neurons, mechanotransduction is sensitive, fast and requires mechanosensitive ion channels. Here we develop a new method to directly monitor mechanotransduction at defined regions of the cell-substrate interface. We show that molecular-scale (~13 nm) displacements are sufficient to gate mechanosensitive currents in mouse touch receptors. Using neurons from knockout mice, we show that displacement thresholds increase by one order of magnitude in the absence of stomatin-like protein 3 (STOML3). Piezo1 is the founding member of a class of mammalian stretch-activated ion channels, and we show that STOML3, but not other stomatin-domain proteins, brings the activation threshold for Piezo1 and Piezo2 currents down to ~10 nm. Structure-function experiments localize the Piezo modulatory activity of STOML3 to the stomatin domain, and higher-order scaffolds are a prerequisite for function. STOML3 is the first potent modulator of Piezo channels that tunes the sensitivity of mechanically gated channels to detect molecular-scale stimuli relevant for fine touch.

216 citations

Journal ArticleDOI
TL;DR: In this article, the authors examined how psychological safety fosters knowledge-sharing processes and enables team creative performance using survey data collected from 73 patient-centred healthcare teams working in the field on rare diseases.
Abstract: We examined how psychological safety fosters knowledge-sharing processes and enables team creative performance. Using a multi-respondent design, we tested our hypotheses using survey data collected from 73 patient-centred healthcare teams working in the field on rare diseases. The data were analysed using latent class regression analysis. We confirmed that a high level of psychological safety within the team is a significant predictor of creative team performance and is mediated by the sharing of two types of knowledge: information and know-how.

216 citations


Authors

Showing all 27602 results

NameH-indexPapersCitations
Markus Antonietti1761068127235
Jian Li133286387131
Klaus-Robert Müller12976479391
Michael Wagner12435154251
Shi Xue Dou122202874031
Xinchen Wang12034965072
Michael S. Feld11955251968
Jian Liu117209073156
Ary A. Hoffmann11390755354
Stefan Grimme113680105087
David M. Karl11246148702
Lester Packer11275163116
Andreas Heinz108107845002
Horst Weller10545144273
G. Hughes10395746632
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023191
2022650
20213,307
20203,387
20193,105
20182,910