Technical University of Dortmund

About: Technical University of Dortmund is a education organization based out in Dortmund, Nordrhein-Westfalen, Germany. It is known for research contribution in the topics: Context (language use) & Large Hadron Collider. The organization has 13028 authors who have published 27666 publications receiving 615557 citations. The organization is also known as: Dortmund University & University of Dortmund.

European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene

Abstract: Three genome-wide association studies in Europe and the USA have reported eight urinary bladder cancer (UBC) susceptibility loci. Using extended case and control series and 1000 Genomes imputations of 5 340 737 single-nucleotide polymorphisms (SNPs), we searched for additional loci in the European GWAS. The discovery sample set consisted of 1631 cases and 3822 controls from the Netherlands and 603 cases and 37 781 controls from Iceland. For follow-up, we used 3790 cases and 7507 controls from 13 sample sets of European and Iranian ancestry. Based on the discovery analysis, we followed up signals in the urea transporter (UT) gene SLC14A. The strongest signal at this locus was represented by a SNP in intron 3, rs17674580, that reached genome-wide significance in the overall analysis of the discovery and follow-up groups: odds ratio = 1.17, P = 7.6 × 10(-11). SLC14A1 codes for UTs that define the Kidd blood group and are crucial for the maintenance of a constant urea concentration gradient in the renal medulla and, through this, the kidney's ability to concentrate urine. It is speculated that rs17674580, or other sequence variants in LD with it, indirectly modifies UBC risk by affecting urine production. If confirmed, this would support the 'urogenous contact hypothesis' that urine production and voiding frequency modify the risk of UBC.

A systematic review and taxonomy of explanations in decision support and recommender systems

Abstract: With the recent advances in the field of artificial intelligence, an increasing number of decision-making tasks are delegated to software systems. A key requirement for the success and adoption of such systems is that users must trust system choices or even fully automated decisions. To achieve this, explanation facilities have been widely investigated as a means of establishing trust in these systems since the early years of expert systems. With today’s increasingly sophisticated machine learning algorithms, new challenges in the context of explanations, accountability, and trust towards such systems constantly arise. In this work, we systematically review the literature on explanations in advice-giving systems. This is a family of systems that includes recommender systems, which is one of the most successful classes of advice-giving software in practice. We investigate the purposes of explanations as well as how they are generated, presented to users, and evaluated. As a result, we derive a novel comprehensive taxonomy of aspects to be considered when designing explanation facilities for current and future decision support systems. The taxonomy includes a variety of different facets, such as explanation objective, responsiveness, content and presentation. Moreover, we identified several challenges that remain unaddressed so far, for example related to fine-grained issues associated with the presentation of explanations and how explanation facilities are evaluated.

A systematic review and taxonomy of explanations in decision support and recommender systems

Abstract: With the recent advances in the field of artificial intelligence, an increasing number of decision-making tasks are delegated to software systems. A key requirement for the success and adoption of such systems is that users must trust system choices or even fully automated decisions. To achieve this, explanation facilities have been widely investigated as a means of establishing trust in these systems since the early years of expert systems. With today's increasingly sophisticated machine learning algorithms, new challenges in the context of explanations, accountability, and trust towards such systems constantly arise. In this work, we systematically review the literature on explanations in advice-giving systems. This is a family of systems that includes recommender systems, which is one of the most successful classes of advice-giving software in practice. We investigate the purposes of explanations as well as how they are generated, presented to users, and evaluated. As a result, we derive a novel comprehensive taxonomy of aspects to be considered when designing explanation facilities for current and future decision support systems. The taxonomy includes a variety of different facets, such as explanation objective, responsiveness, content and presentation. Moreover, we identified several challenges that remain unaddressed so far, for example related to fine-grained issues associated with the presentation of explanations and how explanation facilities are evaluated.

Measurements of CP violation in the three-body phase space of charmless B-+/- decays

Abstract: The charmless three-body decay modes B±→K±π+π−, B±→K±K+K−, B±→π±K+K− and B±→π±π+π− are reconstructed using data, corresponding to an integrated luminosity of 3.0 fb−1, collected by the LHCb detector. The inclusive CP asymmetries of these modes are measured to be ACP(B±→K±π+π−)=+0.025±0.004±0.004±0.007,ACP(B±→K±K+K−)=−0.036±0.004±0.002±0.007,ACP(B±→π±π+π−)=+0.058±0.008±0.009±0.007,ACP(B±→π±K+K−)=−0.123±0.017±0.012±0.007, where the first uncertainty is statistical, the second systematic, and the third is due to the CP asymmetry of the B±→J/ψK± reference mode. The distributions of these asymmetries are also studied as functions of position in the Dalitz plot and suggest contributions from rescattering and resonance interference processes.