Institution
Technical University of Dortmund
Education•Dortmund, Nordrhein-Westfalen, Germany•
About: Technical University of Dortmund is a education organization based out in Dortmund, Nordrhein-Westfalen, Germany. It is known for research contribution in the topics: Large Hadron Collider & Neutrino. The organization has 13028 authors who have published 27666 publications receiving 615557 citations. The organization is also known as: Dortmund University & University of Dortmund.
Papers published on a yearly basis
Papers
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TL;DR: This review highlights various strategies that have been developed to utilizing exclusive structural features of kinases and thereby modulating their activity allosterically and thought to provide various advantages such as higher selectivity and extended drug target residence times.
Abstract: The modulation of kinase function has become an important goal in modern drug discovery and chemical biology research. In cancer-targeted therapies, kinase inhibitors have been experiencing an upsurge, which can be measured by the increasing number of kinase inhibitors approved by the FDA in recent years. However, lack of efficacy, limited selectivity, and the emergence of acquired drug resistance still represent major bottlenecks in the clinic and challenge inhibitor development. Most known kinase inhibitors target the active kinase and are ATP competitive. A second class of small organic molecules, which address remote sites of the kinase and stabilize enzymatically inactive conformations, is rapidly moving to the forefront of kinase inhibitor research. Such allosteric modulators bind to sites that are less conserved across the kinome and only accessible upon conformational changes. These molecules are therefore thought to provide various advantages such as higher selectivity and extended drug target residence times. This review highlights various strategies that have been developed to utilizing exclusive structural features of kinases and thereby modulating their activity allosterically.
175 citations
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TL;DR: Whereas the effect of ‘strain’ was stable in the four heterogenized experiments, outcomes of the four standardized experiments were highly variable, suggesting that withinSystematic variation improves reproducibility of animal experiments.
Abstract: measures to compare between-experiment variation for the standardized and heterogenized design. Whereas strain differences were relatively consistent among heterogenized experiments, they varied considerably between standardized experiments (Fig. 1a–c). In 33 of 36 measures, between-experiment variation was lower in the heterogenized design, indicating better reproducibility. We also analyzed each experiment separately as if conducted independently in different laboratories and assessed the effect of ‘strain’ on each of the 36 measures using a general linear model (GLM). Based on the 2 × 2 factorial nature of the heterogenized design and cage position in the rack, we divided each replicate experiment into four ‘blocks’, each comprising one cage per strain (Supplementary Fig. 1), and included ‘block’ nested within experiment as blocking factor in the GLM (Supplementary Methods). Whereas the effect of ‘strain’ was stable in the four heterogenized experiments, outcomes of the four standardized experiments were highly variable (Supplementary Fig. 2), suggesting that withinSystematic variation improves reproducibility of animal experiments
175 citations
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TL;DR: In this paper, an attempt is made to extract the gluon distributionG(x, Q2=4 GeV2) from the observed scaling violations of structure functions.
Abstract: Using recent data on deep inelastic lepton-nucleon scattering an attempt is made to extract the gluon distributionG(x, Q
2=4 GeV2) from the observed scaling violations of structure functions. The accuracy of the data allows only for a rough determination of the gluon distribution. In particular it is found that a hard gluon distributionis consistent with present measurements. Implications of the hard gluon distribution for charm production in the gluon fusion model and for the perturbative contributions to σ
L
/σ
T
are further discussed. Finally, analytic parametrizations of the QCDx- andQ
2-dependence of quark and gluon distributions are presented facilitating further possible applications.
174 citations
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TL;DR: A novel magneto-optical phenomenon that originates solely from suitably designed nanostructured metal-dielectric material, the so-called Magneto-plasmonic crystal, which allows manipulating and exciting waveguide modes by a magnetic field and light of proper polarization.
Abstract: Magnetic field control of light is among the most intriguing methods for modulation of light intensity and polarization on sub-nanosecond timescales. The implementation in nanostructured hybrid materials provides a remarkable increase of magneto-optical effects. However, so far only the enhancement of already known effects has been demonstrated in such materials. Here we postulate a novel magneto-optical phenomenon that originates solely from suitably designed nanostructured metal-dielectric material, the so-called magneto-plasmonic crystal. In this material, an incident light excites coupled plasmonic oscillations and a waveguide mode. An in-plane magnetic field allows excitation of an orthogonally polarized waveguide mode that modifies optical spectrum of the magneto-plasmonic crystal and increases its transparency. The experimentally achieved light intensity modulation reaches 24%. As the effect can potentially exceed 100%, it may have great importance for applied nanophotonics. Further, the effect allows manipulating and exciting waveguide modes by a magnetic field and light of proper polarization.
174 citations
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TL;DR: Combined 95% confidence-level upper limits are set on the production cross section for a range of vectorlike quark scenarios, significantly improving upon the reach of the individual searches.
Abstract: A combination of the searches for pair-produced vectorlike partners of the top and bottom quarks in various decay channels (T -> Zt/Wb/Ht, B -> Zb/Wt/Hb) is performed using 36.1 fb(-1) of pp ...
174 citations
Authors
Showing all 13240 results
Name | H-index | Papers | Citations |
---|---|---|---|
Hermann Kolanoski | 145 | 1279 | 96152 |
Marc Besancon | 143 | 1799 | 106869 |
Kerstin Borras | 133 | 1341 | 92173 |
Emmerich Kneringer | 129 | 1021 | 80898 |
Achim Geiser | 129 | 1331 | 84136 |
Valerio Vercesi | 129 | 937 | 79519 |
Jens Weingarten | 128 | 896 | 74667 |
Giuseppe Mornacchi | 127 | 894 | 75830 |
Kevin Kroeninger | 126 | 836 | 70010 |
Daniel Muenstermann | 126 | 885 | 70855 |
Reiner Klingenberg | 126 | 733 | 70069 |
Claus Gössling | 126 | 775 | 71975 |
Diane Cinca | 126 | 822 | 70126 |
Frank Meier | 124 | 677 | 64889 |
Daniel Dobos | 124 | 679 | 67434 |