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Institution

Technion – Israel Institute of Technology

EducationHaifa, Israel
About: Technion – Israel Institute of Technology is a education organization based out in Haifa, Israel. It is known for research contribution in the topics: Population & Upper and lower bounds. The organization has 31714 authors who have published 79377 publications receiving 2603976 citations. The organization is also known as: Technion Israel Institute of Technology & Ṭekhniyon, Makhon ṭekhnologi le-Yiśraʼel.


Papers
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Proceedings ArticleDOI
14 Feb 2004
TL;DR: The characterization of interconnect power in a state-of-the-art high-performance microprocessor designed for power efficiency shows the obtainable benefits of tuning physical design algorithms to save power.
Abstract: Interconnect power is dynamic power dissipation due to switching of interconnection capacitances. This paper describes the characterization of interconnect power in a state-of-the-art high-performance microprocessor designed for power efficiency. The analysis showed that interconnect power is over 50% of the dynamic power. Over 90% of the interconnect power is consumed by only 10% of the interconnections. Relations of interconnect power to wire length distribution and hierarchy level of nets were examined. In light of the results, a router's algorithms were modified, to use larger wire spacing and minimal length routing for the high power consuming interconnects. The power-aware router algorithm was tested on synthesized blocks, demonstrating average saving of 14% in the dynamic power consumption without timing degradation or area increase. The results demonstrate the obtainable benefits of tuning physical design algorithms to save power.

462 citations

Journal ArticleDOI
TL;DR: Increasing cartilage AGE crosslinking by in vitro incubation with threose resulted in increased stiffness of the collagen network, which may contribute to the age-related failure ofThe collagen network in human articular cartilage to resist damage.
Abstract: Objective. Age is an important risk factor for osteoarthritis (OA). During aging, nonenzymatic glycation results in the accumulation of advanced glycation end products (AGEs) in cartilage collagen. We studied the effect of AGE crosslinking on the stiffness of the collagen network in human articular cartilage. Methods. To increase AGE levels, human adult articular cartilage was incubated with threose. The stiffness of the collagen network was measured as the instantaneous deformation (ID) of the cartilage and as the change in tensile stress in the collagen network as a function of hydration (osmotic stress technique). AGE levels in the collagen network were determined as: Ne-(carboxy[m]ethyl)lysine, pentosidine, amino acid modification (loss of arginine and [hydroxy-]lysine), AGE fluorescence (360/460 nm), and digestibility by bacterial collagenase. Results. Incubation of cartilage with threose resulted in a dose-dependent increase in AGEs and a concomitant decrease in ID (r = -0.81, P < 0.001; up to a 40% decrease at 200 mM threose), i.e., increased stiffness, which was confirmed by results from the osmotic stress technique. The decreased ID strongly correlated with AGE levels (e.g., AGE fluorescence r = -0.81, P < 0.0001). Coincubation with arginine or lysine (glycation inhibitors) attenuated the threose-induced decrease in ID (P < 0.05). Conclusion. Increasing cartilage AGE crosslinking by in vitro incubation with threose resulted in increased stiffness of the collagen network. Increased stiffness by AGE crosslinking may contribute to the age-related failure of the collagen network in human articular cartilage to resist damage. Thus, the age-related accumulation of AGE crosslinks presents a putative molecular mechanism whereby age is a predisposing factor for the development of OA.

460 citations

Journal ArticleDOI
TL;DR: In this paper, a matrix that juxtaposes BIM functionalities with prescriptive lean construction principles is used to explore the degree of validity of the interactions between the two paradigms and find that a synergy exists which, if properly understood in theoretical terms, can be exploited to improve construction processes beyond the degree to which it might be improved by application of either of them independently.
Abstract: Lean construction and Building Information Modeling are quite different initiatives, but both are having profound impacts on the construction industry. A rigorous analysis of the myriad specific interactions between them indicates that a synergy exists which, if properly understood in theoretical terms, can be exploited to improve construction processes beyond the degree to which it might be improved by application of either of these paradigms independently. Using a matrix that juxtaposes BIM functionalities with prescriptive lean construction principles, fifty-six interactions have been identified, all but four of which represent constructive interaction. Although evidence for the majority of these has been found, the matrix is not considered complete, but rather a framework for research to explore the degree of validity of the interactions. Construction executives, managers, designers and developers of IT systems for construction can also benefit from the framework as an aid to recognizing the potential synergies when planning their lean and BIM adoption strategies.

460 citations

Journal ArticleDOI
TL;DR: In this article, the strategic reference point (SRP) matrix is developed, and a theory is developed which posits an optimal SRP structure, and propositions are offered which articulate the expected relationships between the SRP, strategic choice behavior, and firm performance.
Abstract: How can executives achieve a match between expected external environmental conditions and internal organizational capabilities that facilitates improved performance? This paper argues that a firm's choice of ‘reference points’ can help achieve strategic alignment capable of yielding improved performance and potentially even a sustainable competitive advantage. Building upon prospect theory and other relevant theoretical perspectives, the strategic reference point (SRP) matrix is developed. A firm's SRP consists of three dimensions: internal capability, external conditions, and time. A theory is developed which posits an optimal SRP structure, and propositions are offered which articulate the expected relationships between the SRP, strategic choice behavior, and firm performance. The paper closes with some suggestions for using strategic reference points in both research and practice.

459 citations


Authors

Showing all 31937 results

NameH-indexPapersCitations
Robert Langer2812324326306
Nicholas G. Martin1921770161952
Tobin J. Marks1591621111604
Grant W. Montgomery157926108118
David Eisenberg156697112460
David J. Mooney15669594172
Dirk Inzé14964774468
Jerrold M. Olefsky14359577356
Joseph J.Y. Sung142124092035
Deborah Estrin135562106177
Bruce Yabsley133119184889
Jerry W. Shay13363974774
Richard N. Bergman13047791718
Shlomit Tarem129130686919
Allen Mincer129104080059
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023147
2022390
20213,397
20203,526
20193,273
20183,131