Institution
Technion – Israel Institute of Technology
Education•Haifa, Israel•
About: Technion – Israel Institute of Technology is a education organization based out in Haifa, Israel. It is known for research contribution in the topics: Population & Upper and lower bounds. The organization has 31714 authors who have published 79377 publications receiving 2603976 citations. The organization is also known as: Technion Israel Institute of Technology & Ṭekhniyon, Makhon ṭekhnologi le-Yiśraʼel.
Topics: Population, Upper and lower bounds, Nonlinear system, Decoding methods, Large Hadron Collider
Papers published on a yearly basis
Papers
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National Renewable Energy Laboratory1, Massachusetts Institute of Technology2, Weizmann Institute of Science3, Princeton University4, Georgia Institute of Technology5, Bar-Ilan University6, University of Utah7, Duke University8, Technion – Israel Institute of Technology9, University of Pennsylvania10, University of California, Los Angeles11, SLAC National Accelerator Laboratory12
TL;DR: The conclusions reached by a diverse group of scientists who attended an intense 2-day workshop on hybrid organic-inorganic perovskites are presented, including their thoughts on the most burning fundamental and practical questions regarding this unique class of materials.
Abstract: The conclusions reached by a diverse group of scientists who attended an intense 2-day workshop on hybrid organic-inorganic perovskites are presented, including their thoughts on the most burning fundamental and practical questions regarding this unique class of materials, and their suggestions on various approaches to resolve these issues.
381 citations
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TL;DR: EGCG has protective effects against Aβ‐induced neurotoxicity and regulates secretory processing of non‐amyloidogenic APP via PKC pathway and is not only able to protect, but it can rescue PC12 cells against the β‐ameloid (Aβ) toxicity in a dose‐dependent manner.
Abstract: Green tea extract and its main polyphenol constituent (-)-epigallocatechin-3-gallate (EGCG) possess potent neuroprotective activity in cell culture and mice model of Parkinson's disease. The central hypothesis guiding this study is that EGCG may play an important role in amyloid precursor protein (APP) secretion and protection against toxicity induced by beta-amyloid (Abeta). The present study shows that EGCG enhances (approximately 6-fold) the release of the non-amyloidogenic soluble form of the amyloid precursor protein (sAPPalpha) into the conditioned media of human SH-SY5Y neuroblastoma and rat pheochromocytoma PC12 cells. sAPPalpha release was blocked by the hydroxamic acid-based metalloprotease inhibitor Ro31-9790, which indicated mediation via alpha-secretase activity. Inhibition of protein kinase C (PKC) with the inhibitor GF109203X, or by down-regulation of PKC, blocked the EGCG-induced sAPPalpha secretion, suggesting the involvement of PKC. Indeed, EGCG induced the phosphorylation of PKC, thus identifying a novel PKC-dependent mechanism of EGCG action by activation of the non-amyloidogenic pathway. EGCG is not only able to protect, but it can rescue PC12 cells against the beta-amyloid (Abeta) toxicity in a dose-dependent manner. In addition, administration of EGCG (2 mg/kg) to mice for 7 or 14 days significantly decreased membrane-bound holoprotein APP levels, with a concomitant increase in sAPPalpha levels in the hippocampus. Consistently, EGCG markedly increased PKCalpha and PKC in the membrane and the cytosolic fractions of mice hippocampus. Thus, EGCG has protective effects against Abeta-induced neurotoxicity and regulates secretory processing of non-amyloidogenic APP via PKC pathway.
380 citations
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TL;DR: It is shown that unmethylated regions (UMRs) seem to be formed during early embryogenesis, not as a result of CpG-ness, but rather through the recognition of specific sequence motifs closely associated with transcription start sites.
Abstract: CpG island-like sequences are commonly thought to provide the sole signals for designating constitutively unmethylated regions in the genome, thus generating open chromatin domains within a sea of global repression. Using a new database obtained from comprehensive microarray analysis, we show that unmethylated regions (UMRs) seem to be formed during early embryogenesis, not as a result of CpG-ness, but rather through the recognition of specific sequence motifs closely associated with transcription start sites. This same system probably brings about the resetting of pluripotency genes during somatic cell reprogramming. The data also reveal a new class of nonpromoter UMRs that become de novo methylated in a tissue-specific manner during development, and this process may be involved in gene regulation. In short, we show that UMRs are an important aspect of genome structure that have a dynamic role in development.
380 citations
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TL;DR: A new version of the widely-used PROSPECT model is presented, hereafter namedPROSPECT-D for dynamic, which adds anthocyanins to chlorophylls and carotenoids, the two plant pigments in the current version, and outperforms all the previous versions.
380 citations
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TL;DR: The alliance between the shared-aperture concepts and the geometric phase phenomenon arising from spin-orbit interaction provides a route to implement photonic spin-control multifunctional metasurfaces to improve functionality in photonics.
Abstract: The shared-aperture phased antenna array developed in the field of radar applications is a promising approach for increased functionality in photonics. The alliance between the shared-aperture concepts and the geometric phase phenomenon arising from spin-orbit interaction provides a route to implement photonic spin-control multifunctional metasurfaces. We adopted a thinning technique within the shared-aperture synthesis and investigated interleaved sparse nanoantenna matrices and the spin-enabled asymmetric harmonic response to achieve helicity-controlled multiple structured wavefronts such as vortex beams carrying orbital angular momentum. We used multiplexed geometric phase profiles to simultaneously measure spectrum characteristics and the polarization state of light, enabling integrated on-chip spectropolarimetric analysis. The shared-aperture metasurface platform opens a pathway to novel types of nanophotonic functionality.
380 citations
Authors
Showing all 31937 results
Name | H-index | Papers | Citations |
---|---|---|---|
Robert Langer | 281 | 2324 | 326306 |
Nicholas G. Martin | 192 | 1770 | 161952 |
Tobin J. Marks | 159 | 1621 | 111604 |
Grant W. Montgomery | 157 | 926 | 108118 |
David Eisenberg | 156 | 697 | 112460 |
David J. Mooney | 156 | 695 | 94172 |
Dirk Inzé | 149 | 647 | 74468 |
Jerrold M. Olefsky | 143 | 595 | 77356 |
Joseph J.Y. Sung | 142 | 1240 | 92035 |
Deborah Estrin | 135 | 562 | 106177 |
Bruce Yabsley | 133 | 1191 | 84889 |
Jerry W. Shay | 133 | 639 | 74774 |
Richard N. Bergman | 130 | 477 | 91718 |
Shlomit Tarem | 129 | 1306 | 86919 |
Allen Mincer | 129 | 1040 | 80059 |