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Institution

Technion – Israel Institute of Technology

EducationHaifa, Israel
About: Technion – Israel Institute of Technology is a education organization based out in Haifa, Israel. It is known for research contribution in the topics: Population & Upper and lower bounds. The organization has 31714 authors who have published 79377 publications receiving 2603976 citations. The organization is also known as: Technion Israel Institute of Technology & Ṭekhniyon, Makhon ṭekhnologi le-Yiśraʼel.


Papers
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Journal ArticleDOI
TL;DR: High-resolution crystal structures of sequence-specific complexes between the core domain of human p53 and different DNA half-sites are presented and establish a structural framework for understanding the mechanisms of specificity, affinity, and cooperativity of DNA binding by p53.

376 citations

Journal ArticleDOI
TL;DR: The Informed-Source Coding On Demand approach for efficiently supplying nonidentical data from a central server to multiple caching clients over a broadcast channel is presented and k-partial cliques in a directed graph are defined and cast ISCOD in terms of partial-clique covers.
Abstract: The Informed-Source Coding On Demand (ISCOD) approach for efficiently supplying nonidentical data from a central server to multiple caching clients over a broadcast channel is presented. The key idea underlying ISCOD is the joint exploitation of the data blocks already cached by each client, the server's full knowledge of client-cache contents and client requests, and the fact that each client only needs to be able to derive the blocks requested by it rather than all the blocks ever transmitted or even the union of the blocks requested by the different clients. We present two-phase ISCOD algorithms: the server first creates ad-hoc error-correction sets based on its knowledge of client states; next, it uses erasure-correction codes to construct the data for transmission. Each client uses its cached data and the received supplemental data to derive its requested blocks. The result is up to a several-fold reduction in the amount of transmitted supplemental data. Also, we define k-partial cliques in a directed graph and cast ISCOD in terms of partial-clique covers.

375 citations

Journal ArticleDOI
TL;DR: The large repertoire of SAGs identified here provides global insights about regulatory, biochemical and cellular events occurring during leaf senescence, and is likely to participate in macromolecule degradation, detoxification of oxidative metabolites, induction of defense mechanisms, and signaling and regulatory events.
Abstract: Leaf senescence is a form of programmed cell death, and is believed to involve preferential expression of a specific set of "senescence-associated genes" (SAGs). To decipher the molecular mechanisms and the predicted complex network of regulatory pathways involved in the senescence program, we have carried out a large-scale gene identification study in a reference plant, Arabidopsis thaliana. Using suppression subtractive hybridization, we isolated approximately 800 cDNA clones representing SAGs expressed in senescing leaves. Differential expression was confirmed by Northern blot analysis for 130 non-redundant genes. Over 70 of the identified genes have not previously been shown to participate in the senescence process. SAG-encoded proteins are likely to participate in macromolecule degradation, detoxification of oxidative metabolites, induction of defense mechanisms, and signaling and regulatory events. Temporal expression profiles of selected genes displayed several distinct patterns, from expression at a very early stage, to the terminal phase of the senescence syndrome. Expression of some of the novel SAGs, in response to age, leaf detachment, darkness, and ethylene and cytokinin treatment was compared. The large repertoire of SAGs identified here provides global insights about regulatory, biochemical and cellular events occurring during leaf senescence.

375 citations

Journal ArticleDOI
TL;DR: This manuscript documents the development of a validated index for capsule endoscopy findings and states that this index is likely to be applicable to small bowel mucosal inflammatory change.
Abstract: Summary Background Capsule endoscopy can identify small bowel mucosal inflammatory change. However, there has been no validated index for capsule endoscopy findings. This manuscript documents the development of such an index. Aim To develop a capsule endoscopy scoring index for small bowel mucosal inflammatory change. Methods The index was created in four separate steps. First, parameters and descriptors of inflammatory change were identified. Secondly, blinded readers prospectively graded the presence or absence of each parameter on de-identified videos and graded a perceived global assessment of overall severity. Thirdly, the individual parameters and descriptors were ranked in order of severity. Fourthly, values for each parameter were created using the descent gradient methodology. The premise was to assure that the final numerical score reflected the global assessment and that the global assessment agreed with the ranking of finding severity. Results were compiled for the three categories: no or clinically insignificant change, mild change, and moderate or severe change. Thresholds were determined. Results The final index includes three parameters: villous oedema, ulcer and stenosis. A score <135 is designated normal or clinically insignificant mucosal inflammatory change, a score between 135 and 790 is mild, and a score ≥790 is moderate to severe. Conclusion This capsule endoscopy score provides a common language to quantify small bowel inflammatory changes.

374 citations

Journal ArticleDOI
TL;DR: The present paper reviews primarily the topic of basil essential oils with regards to their chemical composition, their effect on microorganisms, the test methods for antimicrobial activity determination, and their possible future use in food preservation or as the active, slow release, component of an active package.
Abstract: Basil (Ocimum basilicum L.) is a popular culinary herb, and its essential oils have been used extensively for many years in food products, perfumery, and dental and oral products. Basil essential oils and their principal constituents were found to exhibit antimicrobial activity against a wide range of Gram-negative and Gram-positive bacteria, yeast, and mold. The present paper reviews primarily the topic of basil essential oils with regards to their chemical composition, their effect on microorganisms, the test methods for antimicrobial activity determination, and their possible future use in food preservation or as the active (antimicrobial), slow release, component of an active package.

374 citations


Authors

Showing all 31937 results

NameH-indexPapersCitations
Robert Langer2812324326306
Nicholas G. Martin1921770161952
Tobin J. Marks1591621111604
Grant W. Montgomery157926108118
David Eisenberg156697112460
David J. Mooney15669594172
Dirk Inzé14964774468
Jerrold M. Olefsky14359577356
Joseph J.Y. Sung142124092035
Deborah Estrin135562106177
Bruce Yabsley133119184889
Jerry W. Shay13363974774
Richard N. Bergman13047791718
Shlomit Tarem129130686919
Allen Mincer129104080059
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023147
2022390
20213,397
20203,526
20193,273
20183,131