Technion – Israel Institute of Technology

About: Technion – Israel Institute of Technology is a education organization based out in Haifa, Israel. It is known for research contribution in the topics: Population & Upper and lower bounds. The organization has 31714 authors who have published 79377 publications receiving 2603976 citations. The organization is also known as: Technion Israel Institute of Technology & Ṭekhniyon, Makhon ṭekhnologi le-Yiśraʼel.

How to play ANY mental game

Abstract: We present a polynomial-time algorithm that, given as a input the description of a game with incomplete information and any number of players, produces a protocol for playing the game that leaks no partial information, provided the majority of the players is honest. Our algorithm automatically solves all the multi-party protocol problems addressed in complexity-based cryptography during the last 10 years. It actually is a completeness theorem for the class of distributed protocols with honest majority. Such completeness theorem is optimal in the sense that, if the majority of the players is not honest, some protocol problems have no efficient solution [C].

Vascular endothelial growth factor (VEGF) and its receptors

Abstract: Vascular endothelial growth factor (VEGF) is a highly specific mitogen for vascular endothelial cells. Five VEGF isoforms are generated as a result of alternative splicing from a single VEGF gene. These isoforms differ in their molecular mass and in biological properties such as their ability to bind to cell-surface heparan-sulfate proteoglycans. The expression of VEGF is potentiated in response to hypoxia, by activated oncogenes, and by a variety of cytokines. VEGF induces endothelial cell proliferation, promotes cell migration, and inhibits apoptosis. In vivo VEGF induces angiogenesis as well as permeabilization of blood vessels, and plays a central role in the regulation of vasculogenesis. Deregulated VEGF expression contributes to the development of solid tumors by promoting tumor angiogenesis and to the etiology of several additional diseases that are characterized by abnormal angiogenesis. Consequently, inhibition of VEGF signaling abrogates the development of a wide variety of tumors. The various VEGF forms bind to two tyrosine-kinase receptors, VEGFR-1 (flt-1) and VEGFR-2 (KDR/flk-1), which are expressed almost exclusively in endothelial cells. Endothelial cells express in addition the neuropilin-1 and neuropilin-2 coreceptors, which bind selectively to the 165 amino acid form of VEGF (VEGF165). This review focuses on recent developments that have widened considerably our understanding of the mechanisms that control VEGF production and VEGF signal transduction and on recent studies that have shed light on the mechanisms by which VEGF regulates angiogenesis.

Metal-free efficient photocatalyst for stable visible water splitting via a two-electron pathway

Abstract: The use of solar energy to produce molecular hydrogen and oxygen (H2 and O2) from overall water splitting is a promising means of renewable energy storage. In the past 40 years, various inorganic and organic systems have been developed as photocatalysts for water splitting driven by visible light. These photocatalysts, however, still suffer from low quantum efficiency and/or poor stability. We report the design and fabrication of a metal-free carbon nanodot-carbon nitride (C3N4) nanocomposite and demonstrate its impressive performance for photocatalytic solar water splitting. We measured quantum efficiencies of 16% for wavelength λ = 420 ± 20 nanometers, 6.29% for λ = 580 ± 15 nanometers, and 4.42% for λ = 600 ± 10 nanometers, and determined an overall solar energy conversion efficiency of 2.0%. The catalyst comprises low-cost, Earth-abundant, environmentally friendly materials and shows excellent stability.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Abstract: Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.

The rate-distortion function for source coding with side information at the decoder

Abstract: Let \{(X_{k}, Y_{k}) \}^{ \infty}_{k=1} be a sequence of independent drawings of a pair of dependent random variables X, Y . Let us say that X takes values in the finite set \cal X . It is desired to encode the sequence \{X_{k}\} in blocks of length n into a binary stream of rate R , which can in turn be decoded as a sequence \{ \hat{X}_{k} \} , where \hat{X}_{k} \in \hat{ \cal X} , the reproduction alphabet. The average distortion level is (1/n) \sum^{n}_{k=1} E[D(X_{k},\hat{X}_{k})] , where D(x,\hat{x}) \geq 0, x \in {\cal X}, \hat{x} \in \hat{ \cal X} , is a preassigned distortion measure. The special assumption made here is that the decoder has access to the side information \{Y_{k}\} . In this paper we determine the quantity R \ast (d) , defined as the infimum ofrates R such that (with \varepsilon > 0 arbitrarily small and with suitably large n )communication is possible in the above setting at an average distortion level (as defined above) not exceeding d + \varepsilon . The main result is that R \ast (d) = \inf [I(X;Z) - I(Y;Z)] , where the infimum is with respect to all auxiliary random variables Z (which take values in a finite set \cal Z ) that satisfy: i) Y,Z conditionally independent given X ; ii) there exists a function f: {\cal Y} \times {\cal Z} \rightarrow \hat{ \cal X} , such that E[D(X,f(Y,Z))] \leq d . Let R_{X | Y}(d) be the rate-distortion function which results when the encoder as well as the decoder has access to the side information \{ Y_{k} \} . In nearly all cases it is shown that when d > 0 then R \ast(d) > R_{X|Y} (d) , so that knowledge of the side information at the encoder permits transmission of the \{X_{k}\} at a given distortion level using a smaller transmission rate. This is in contrast to the situation treated by Slepian and Wolf [5] where, for arbitrarily accurate reproduction of \{X_{k}\} , i.e., d = \varepsilon for any \varepsilon >0 , knowledge of the side information at the encoder does not allow a reduction of the transmission rate.