Institution
Technion – Israel Institute of Technology
Education•Haifa, Israel•
About: Technion – Israel Institute of Technology is a education organization based out in Haifa, Israel. It is known for research contribution in the topics: Population & Upper and lower bounds. The organization has 31714 authors who have published 79377 publications receiving 2603976 citations. The organization is also known as: Technion Israel Institute of Technology & Ṭekhniyon, Makhon ṭekhnologi le-Yiśraʼel.
Topics: Population, Upper and lower bounds, Nonlinear system, Decoding methods, Large Hadron Collider
Papers published on a yearly basis
Papers
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TL;DR: It is conjectured that the barrier of O(log n) cannot be surpassed by any polynomial number of processors and that this performance cannot be achieved in the weaker model.
628 citations
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TL;DR: In this article, the authors show that photorefractive media can support a new type of spatial soliton, in which the diffraction is balanced by the self-scattering (two-wave mixing) of the beam spatial frequency components.
Abstract: We show that photorefractive media can support a new type of spatial soliton, in which the diffraction is balanced by the self-scattering (two-wave mixing) of the beam spatial frequency components. This photorefractive soliton possessses some unique properties, such as independence of the absolute light intensity, and can experience absorption (or gain) with no change in its transverse structure.
626 citations
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TL;DR: It is demonstrated that p27 ubiquitination (as assayed in vivo and in an in vitro reconstituted system) is cell-cycle regulated and that Cdk activity is required for the in vitro ubiquitinations of p27.
Abstract: The cellular abundance of the cyclin-dependent kinase (Cdk) inhibitor p27 is regulated by the ubiquitin–proteasome system. Activation of p27 degradation is seen in proliferating cells and in many types of aggressive human carcinomas. p27 can be phosphorylated on threonine 187 by Cdks, and cyclin E/Cdk2 overexpression can stimulate the degradation of wild-type p27, but not of a threonine 187-to-alanine p27 mutant [p27(T187A)]. However, whether threonine 187 phosphorylation stimulates p27 degradation through the ubiquitin–proteasome system or an alternative pathway is still not known. Here, we demonstrate that p27 ubiquitination (as assayed in vivo and in an in vitro reconstituted system) is cell-cycle regulated and that Cdk activity is required for the in vitro ubiquitination of p27. Furthermore, ubiquitination of wild-type p27, but not of p27(T187A), can occur in G1-enriched extracts only upon addition of cyclin E/Cdk2 or cyclin A/Cdk2. Using a phosphothreonine 187 site-specific antibody for p27, we show that threonine 187 phosphorylation of p27 is also cell-cycle dependent, being present in proliferating cells but undetectable in G1 cells. Finally, we show that in addition to threonine 187 phosphorylation, efficient p27 ubiquitination requires formation of a trimeric complex with the cyclin and Cdk subunits. In fact, cyclin B/Cdk1 which can phosphorylate p27 efficiently, but cannot form a stable complex with it, is unable to stimulate p27 ubiquitination by G1 extracts. Furthermore, another p27 mutant [p27(CK−)] that can be phosphorylated by cyclin E/Cdk2 but cannot bind this kinase complex, is refractory to ubiquitination. Thus throughout the cell cycle, both phosphorylation and trimeric complex formation act as signals for the ubiquitination of a Cdk inhibitor.
626 citations
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TL;DR: A survey of methods for imposition of radiation boundary conditions in numerical schemes is presented in this article, where combining of absorbing boundary conditions with damping (in particular, sponge filters) and with wave-speed modification are shown to offer significant improvements over earlier methods.
625 citations
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Katholieke Universiteit Leuven1, University of Texas MD Anderson Cancer Center2, Johns Hopkins University3, University of Texas Health Science Center at San Antonio4, University of Cologne5, University of Manitoba6, Sheba Medical Center7, Université libre de Bruxelles8, University of Alabama at Birmingham9, Tel Aviv University10, University of Würzburg11, University of Strasbourg12, University of Liverpool13, München Klinik Bogenhausen14, Catholic University of Korea15, Necker-Enfants Malades Hospital16, University of Minnesota17, Technion – Israel Institute of Technology18, University of California, Davis19, Center for Global Development20
TL;DR: The results support the use of isavuconazole for the primary treatment of patients with invasive mould disease and non-inferiority was shown.
622 citations
Authors
Showing all 31937 results
Name | H-index | Papers | Citations |
---|---|---|---|
Robert Langer | 281 | 2324 | 326306 |
Nicholas G. Martin | 192 | 1770 | 161952 |
Tobin J. Marks | 159 | 1621 | 111604 |
Grant W. Montgomery | 157 | 926 | 108118 |
David Eisenberg | 156 | 697 | 112460 |
David J. Mooney | 156 | 695 | 94172 |
Dirk Inzé | 149 | 647 | 74468 |
Jerrold M. Olefsky | 143 | 595 | 77356 |
Joseph J.Y. Sung | 142 | 1240 | 92035 |
Deborah Estrin | 135 | 562 | 106177 |
Bruce Yabsley | 133 | 1191 | 84889 |
Jerry W. Shay | 133 | 639 | 74774 |
Richard N. Bergman | 130 | 477 | 91718 |
Shlomit Tarem | 129 | 1306 | 86919 |
Allen Mincer | 129 | 1040 | 80059 |