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Showing papers by "Technische Universität Darmstadt published in 2011"


Journal ArticleDOI
TL;DR: This paper proposes a new set of benchmarks and evaluation methods for the next generation of optical flow algorithms and analyzes the results obtained to date to draw a large number of conclusions.
Abstract: The quantitative evaluation of optical flow algorithms by Barron et al. (1994) led to significant advances in performance. The challenges for optical flow algorithms today go beyond the datasets and evaluation methods proposed in that paper. Instead, they center on problems associated with complex natural scenes, including nonrigid motion, real sensor noise, and motion discontinuities. We propose a new set of benchmarks and evaluation methods for the next generation of optical flow algorithms. To that end, we contribute four types of data to test different aspects of optical flow algorithms: (1) sequences with nonrigid motion where the ground-truth flow is determined by tracking hidden fluorescent texture, (2) realistic synthetic sequences, (3) high frame-rate video used to study interpolation error, and (4) modified stereo sequences of static scenes. In addition to the average angular error used by Barron et al., we compute the absolute flow endpoint error, measures for frame interpolation error, improved statistics, and results at motion discontinuities and in textureless regions. In October 2007, we published the performance of several well-known methods on a preliminary version of our data to establish the current state of the art. We also made the data freely available on the web at http://vision.middlebury.edu/flow/ . Subsequently a number of researchers have uploaded their results to our website and published papers using the data. A significant improvement in performance has already been achieved. In this paper we analyze the results obtained to date and draw a large number of conclusions from them.

2,534 citations


Proceedings ArticleDOI
19 Dec 2011
TL;DR: A system for fast online learning of occupancy grid maps requiring low computational resources is presented that combines a robust scan matching approach using a LIDAR system with a 3D attitude estimation system based on inertial sensing to achieve reliable localization and mapping capabilities in a variety of challenging environments.
Abstract: For many applications in Urban Search and Rescue (USAR) scenarios robots need to learn a map of unknown environments. We present a system for fast online learning of occupancy grid maps requiring low computational resources. It combines a robust scan matching approach using a LIDAR system with a 3D attitude estimation system based on inertial sensing. By using a fast approximation of map gradients and a multi-resolution grid, reliable localization and mapping capabilities in a variety of challenging environments are realized. Multiple datasets showing the applicability in an embedded hand-held mapping system are provided. We show that the system is sufficiently accurate as to not require explicit loop closing techniques in the considered scenarios. The software is available as an open source package for ROS.

919 citations


Book ChapterDOI
14 Feb 2011
TL;DR: A new lattice attack on LWE that combines basis reduction with an enumeration algorithm admitting a time/success tradeoff performs better than the simple distinguishing attack considered in prior analyses.
Abstract: We analyze the concrete security and key sizes of theoretically sound lattice-based encryption schemes based on the "learning with errors" (LWE) problem. Our main contributions are: (1) a new lattice attack on LWE that combines basis reduction with an enumeration algorithm admitting a time/success tradeoff, which performs better than the simple distinguishing attack considered in prior analyses; (2) concrete parameters and security estimates for an LWE-based cryptosystem that is more compact and efficient than the well-known schemes from the literature. Our new key sizes are up to 10 times smaller than prior examples, while providing even stronger concrete security levels.

595 citations


Journal ArticleDOI
TL;DR: In this paper, the centrality dependence of the chargedparticle multiplicity density at midrapidity in Pb-Pb collisions at root s(NN) = 2: 76 TeV is presented.
Abstract: The centrality dependence of the charged-particle multiplicity density at midrapidity in Pb-Pb collisions at root s(NN) = 2: 76 TeV is presented. The charged-particle density normalized per participating nucleon pair increases by about a factor of 2 from peripheral (70%-80%) to central (0%-5%) collisions. The centrality dependence is found to be similar to that observed at lower collision energies. The data are compared with models based on different mechanisms for particle production in nuclear collisions.

553 citations


Posted Content
01 Jan 2011
TL;DR: In this paper, the authors compared four seeding strategies in two complementary small-scale field experiments, as well as in one real-life viral marketing campaign involving more than 200,000 customers of a mobile phone service provider.
Abstract: Seeding strategies have strong influences on the success of viral marketing campaigns, but previous studies using computer simulations and analytical models have produced conflicting recommendations about the optimal seeding strategy. This study compares four seeding strategies in two complementary small-scale field experiments, as well as in one real-life viral marketing campaign involving more than 200,000 customers of a mobile phone service provider. The empirical results show that the best seeding strategies can be up to eight times more successful than other seeding strategies. Seeding to well-connected people is the most successful approach because these attractive seeding points are more likely to participate in viral marketing campaigns. This finding contradicts a common assumption in other studies. Well-connected people also actively use their greater reach but do not have more influence on their peers than do less well-connected people.

534 citations


Journal ArticleDOI
TL;DR: In this paper, a three-valued semantics (with truth values true, false, inconclusive) is introduced as an adequate interpretation as to whether a partial observation of a running system meets an LTL or TLTL property.
Abstract: This article studies runtime verification of properties expressed either in lineartime temporal logic (LTL) or timed lineartime temporal logic (TLTL). It classifies runtime verification in identifying its distinguishing features to model checking and testing, respectively. It introduces a three-valued semantics (with truth values true, false, inconclusive) as an adequate interpretation as to whether a partial observation of a running system meets an LTL or TLTL property.For LTL, a conceptually simple monitor generation procedure is given, which is optimal in two respects: First, the size of the generated deterministic monitor is minimal, and, second, the monitor identifies a continuously monitored trace as either satisfying or falsifying a property as early as possible. The feasibility of the developed methodology is demontrated using a collection of real-world temporal logic specifications. Moreover, the presented approach is related to the properties monitorable in general and is compared to existing concepts in the literature. It is shown that the set of monitorable properties does not only encompass the safety and cosafety properties but is strictly larger.For TLTL, the same road map is followed by first defining a three-valued semantics. The corresponding construction of a timed monitor is more involved, yet, as shown, possible.

533 citations


Journal ArticleDOI
TL;DR: In this article, the authors measured the transverse momentum spectra of primary charged particles in Pb-Pb collisions at root s(NN) = 2.76 TeV at the ALICE Collaboration at the LHC.

519 citations


Journal ArticleDOI
TL;DR: This State‐of‐the‐Art Report surveys available techniques for the visual analysis of large graphs and discusses various graph algorithmic aspects useful for the different stages of the visual graph analysis process.
Abstract: The analysis of large graphs plays a prominent role in various fields of research and is relevant in many important application areas. Effective visual analysis of graphs requires appropriate visual presentations in combination with respective user interaction facilities and algorithmic graph analysis methods. How to design appropriate graph analysis systems depends on many factors, including the type of graph describing the data, the analytical task at hand and the applicability of graph analysis methods. The most recent surveys of graph visualization and navigation techniques cover techniques that had been introduced until 2000 or concentrate only on graph layouts published until 2002. Recently, new techniques have been developed covering a broader range of graph types, such as timevarying graphs. Also, in accordance with ever growing amounts of graph-structured data becoming available, the inclusion of algorithmic graph analysis and interaction techniques becomes increasingly important. In this State-of-the-Art Report, we survey available techniques for the visual analysis of large graphs. Our review first considers graph visualization techniques according to the type of graphs supported. The visualization techniques form the basis for the presentation of interaction approaches suitable for visual graph exploration. As an important component of visual graph analysis, we discuss various graph algorithmic aspects useful for the different stages of the visual graph analysis process. We also present main open research challenges in this field.

518 citations


Journal ArticleDOI
K. Aamodt1, Betty Abelev2, A. Abrahantes Quintana, Dagmar Adamová3  +972 moreInstitutions (84)
11 Jul 2011
TL;DR: The first measurement of the triangular v3, quadrangular v4, and pentagonal v5 charged particle flow in Pb-Pb collisions is reported, and a double peaked structure in the two-particle azimuthal correlations is observed, which can be naturally explained from the measured anisotropic flow Fourier coefficients.
Abstract: We report on the first measurement of the triangular nu(3), quadrangular nu(4), and pentagonal nu(5) charged particle flow in Pb-Pb collisions at root s(NN) = 2.76 TeV measured with the ALICE detector at the CERN Large Hadron Collider. We show that the triangular flow can be described in terms of the initial spatial anisotropy and its fluctuations, which provides strong constraints on its origin. In the most central events, where the elliptic flow nu(2) and nu(3) have similar magnitude, a double peaked structure in the two-particle azimuthal correlations is observed, which is often interpreted as a Mach cone response to fast partons. We show that this structure can be naturally explained from the measured anisotropic flow Fourier coefficients.

515 citations


Journal ArticleDOI
TL;DR: In this article, the authors compared four seeding strategies in two complementary small-scale field experiments, as well as in one real-life viral marketing campaign involving more than 200,000 customers of a mobile phone service provider.
Abstract: Seeding strategies have strong influences on the success of viral marketing campaigns, but previous studies using computer simulations and analytical models have produced conflicting recommendations about the optimal seeding strategy. This study compares four seeding strategies in two complementary small-scale field experiments, as well as in one real-life viral marketing campaign involving more than 200,000 customers of a mobile phone service provider. The empirical results show that the best seeding strategies can be up to eight times more successful than other seeding strategies. Seeding to well-connected people is the most successful approach because these attractive seeding points are more likely to participate in viral marketing campaigns. This finding contradicts a common assumption in other studies. Well-connected people also actively use their greater reach but do not have more influence on their peers than do less well-connected people.

473 citations


Journal ArticleDOI
TL;DR: This survey identifies the sensing modalities used in current participatory sensing applications, and assess the threats to user privacy when personal information is sensed and disclosed, and identifies open issues and possible solutions to guarantee user privacy in Participatory sensing.

Journal ArticleDOI
TL;DR: It is proposed that NHEJ initially attempts to repair DSBs and, if rapid rejoining does not ensue, then resection occurs promoting repair by HR, and novel roles for ATM in regulating DSB end resection are identified.
Abstract: DNA non-homologous end joining (NHEJ) and homologous recombination (HR) function to repair DNA double-strand breaks (DSBs) in G2 phase with HR preferentially repairing heterochromatin-associated DSBs (HC-DSBs). Here, we examine the regulation of repair pathway usage at two-ended DSBs in G2. We identify the speed of DSB repair as a major component influencing repair pathway usage showing that DNA damage and chromatin complexity are factors influencing DSB repair rate and pathway choice. Loss of NHEJ proteins also slows DSB repair allowing increased resection. However, expression of an autophosphorylation-defective DNA-PKcs mutant, which binds DSBs but precludes the completion of NHEJ, dramatically reduces DSB end resection at all DSBs. In contrast, loss of HR does not impair repair by NHEJ although CtIP-dependent end resection precludes NHEJ usage. We propose that NHEJ initially attempts to repair DSBs and, if rapid rejoining does not ensue, then resection occurs promoting repair by HR. Finally, we identify novel roles for ATM in regulating DSB end resection; an indirect role in promoting KAP-1-dependent chromatin relaxation and a direct role in phosphorylating and activating CtIP.

Journal ArticleDOI
TL;DR: The design and synthesis of well-defined nanocrystals which are uniform in size, shape and surface structure are ideal candidates for fundamental studies of mechanisms of gas sensing which should involve gas sensing measurements on specific surfaces, their atomistic/quantum chemical modelling and spectroscopic information obtained on same surfaces under operation conditions of sensors.
Abstract: Anisotropy is a basic property of single crystals. Dissimilar facets/surfaces have different geometric and electronic structure that results in dissimilar functional properties. Several case studies unambiguously demonstrated that the gas sensing activity of metal oxides is determined by the nature of surfaces exposed to ambient gas. Accordingly, a control over crystal morphology, i.e. over the angular relationships, size and shape of faces in a crystal, is required for the development of better sensors with increased selectivity and sensitivity in the chemical determination of gases. The first step toward this nanomorphological control of the gas sensing properties is the design and synthesis of well-defined nanocrystals which are uniform in size, shape and surface structure. These materials possess the planes of the symmetrical set {hkl} and must therefore behave identically in chemical reactions and adsorption processes. Because of these characteristics, the form-controlled nanocrystals are ideal candidates for fundamental studies of mechanisms of gas sensing which should involve (i) gas sensing measurements on specific surfaces, (ii) their atomistic/quantum chemical modelling and (ii) spectroscopic information obtained on same surfaces under operation conditions of sensors.

Journal ArticleDOI
TL;DR: In this paper, a mini-review is devoted to coaxial electrospinning (co-electrospinning), a group of novel methods for making core-shell nanofibers and hollow nanotubes.
Abstract: The mini-review is devoted to coaxial electrospinning (co-electrospinning, emulsion electrospinning), a group of novel methods for making core–shell nanofibers and hollow nanotubes. The physical aspects of the process are described in brief, in particular, its modeling and possible drawbacks of the process resulting in formation of fibers without a long intact core. After that the main applications of co-electrospinning are considered. They include drug release, encapsulation of different biologically active compounds, cell scaffolds, formation of nanotubes, and nanofluidics. Copyright © 2010 John Wiley & Sons, Ltd.

Journal ArticleDOI
TL;DR: The extracted E1 polarizability leads to a neutron skin thickness close to that of a neutron star, thereby constraining the symmetry energy and its density dependence relevant to the description of neutron stars.
Abstract: A benchmark experiment on Pb-208 shows that polarized proton inelastic scattering at very forward angles including 0 degrees is a powerful tool for high-resolution studies of electric dipole (E1) and spin magnetic dipole (M1) modes in nuclei over a broad excitation energy range to test up-to-date nuclear models. The extracted E1 polarizability leads to a neutron skin thickness r(skin) = 0.156(-0.021)(+0.025) fm in Pb-208 derived within a mean-field model [Phys. Rev. C 81, 051303 (2010)], thereby constraining the symmetry energy and its density dependence relevant to the description of neutron stars.

Journal ArticleDOI
TL;DR: A review of recently acquired knowledge on the physico-chemical properties of mineral dust from Africa and Asia based on data presented and discussed during the Third International Dust Workshop, held in Leipzig (Germany) in September 2008 is presented in this paper.
Abstract: . This paper presents a review of recently acquired knowledge on the physico-chemical properties of mineral dust from Africa and Asia based on data presented and discussed during the Third International Dust Workshop, held in Leipzig (Germany) in September 2008. Various regional field experiments have been conducted in the last few years, mostly close to source regions or after short-range transport. Although significant progress has been made in characterising the regional variability of dust properties close to source regions, in particular the mineralogy of iron and the description of particle shape and mixing state, difficulties remain in estimating the range of variability of those properties within one given source region. As consequence, the impact of these parameters on aerosol properties like optical properties, solubility, hygroscopicity, etc. – determining the dust impact on climate – is only partly understood. Long-term datasets in remote regions such as the dust source regions remain a major desideratum. Future work should also focus on the evolution of dust properties during transport. In particular, the prediction of the mineral dust size distribution at emission and their evolution during transport should be considered as a high-priority. From the methodological point of view, a critical assessment and standardisation of the experimental and analytical techniques is highly recommended. Techniques to characterize the internal state of mixing of dust particles, particularly with organic material, should be further developed.

Proceedings ArticleDOI
20 Jun 2011
TL;DR: This work proposes to formulate multi-target tracking as minimization of a continuous energy function, and constructs a suitable optimization scheme to find strong local minima of the proposed energy.
Abstract: We propose to formulate multi-target tracking as minimization of a continuous energy function. Other than a number of recent approaches we focus on designing an energy function that represents the problem as faithfully as possible, rather than one that is amenable to elegant optimization. We then go on to construct a suitable optimization scheme to find strong local minima of the proposed energy. The scheme extends the conjugate gradient method with periodic trans-dimensional jumps. These moves allow the search to escape weak minima and explore a much larger portion of the variable-dimensional search space, while still always reducing the energy. To demonstrate the validity of this approach we present an extensive quantitative evaluation both on synthetic data and on six different real video sequences. In both cases we achieve a significant performance improvement over an extended Kalman filter baseline as well as an ILP-based state-of-the-art tracker.

Journal ArticleDOI
TL;DR: Risks from treatments such as particle therapy have not yet been determined and are unlikely to become apparent for many years, therefore, there is a need to develop risk assessments based on current knowledge of radiation-induced carcinogenesis.
Abstract: Recent advances in radiotherapy have enabled the use of different types of particles, such as protons and heavy ions, as well as refinements to the treatment of tumours with standard sources (photons). However, the risk of second cancers arising in long-term survivors continues to be a problem. The long-term risks from treatments such as particle therapy have not yet been determined and are unlikely to become apparent for many years. Therefore, there is a need to develop risk assessments based on our current knowledge of radiation-induced carcinogenesis.

Book ChapterDOI
04 Dec 2011
TL;DR: In this article, the authors introduce the concept of a history-free reduction which is a category of classical random oracle reductions that basically determine oracle answers independently of the history of previous queries, and prove that such reductions imply security in the quantum model.
Abstract: The interest in post-quantum cryptography -- classical systems that remain secure in the presence of a quantum adversary -- has generated elegant proposals for new cryptosystems. Some of these systems are set in the random oracle model and are proven secure relative to adversaries that have classical access to the random oracle. We argue that to prove post-quantum security one needs to prove security in the quantum-accessible random oracle model where the adversary can query the random oracle with quantum state. We begin by separating the classical and quantum-accessible random oracle models by presenting a scheme that is secure when the adversary is given classical access to the random oracle, but is insecure when the adversary can make quantum oracle queries. We then set out to develop generic conditions under which a classical random oracle proof implies security in the quantum-accessible random oracle model. We introduce the concept of a history-free reduction which is a category of classical random oracle reductions that basically determine oracle answers independently of the history of previous queries, and we prove that such reductions imply security in the quantum model. We then show that certain post-quantum proposals, including ones based on lattices, can be proven secure using history-free reductions and are therefore postquantum secure. We conclude with a rich set of open problems in this area.

Journal ArticleDOI
TL;DR: In this article, the physical basis of space radiation protection is described, including the most recent achievements in space radiation transport codes and shielding approaches, and improved risk assessment and genetic and biomedical approaches are a more likely solution to GCR radiation protection issues.
Abstract: The health risks of space radiation are arguably the most serious challenge to space exploration, possibly preventing these missions due to safety concerns or increasing their costs to amounts beyond what would be acceptable. Radiation in space is substantially different from Earth: high-energy ($E$) and charge ($Z$) particles (HZE) provide the main contribution to the equivalent dose in deep space, whereas $\ensuremath{\gamma}$ rays and low-energy $\ensuremath{\alpha}$ particles are major contributors on Earth. This difference causes a high uncertainty on the estimated radiation health risk (including cancer and noncancer effects), and makes protection extremely difficult. In fact, shielding is very difficult in space: the very high energy of the cosmic rays and the severe mass constraints in spaceflight represent a serious hindrance to effective shielding. Here the physical basis of space radiation protection is described, including the most recent achievements in space radiation transport codes and shielding approaches. Although deterministic and Monte Carlo transport codes can now describe well the interaction of cosmic rays with matter, more accurate double-differential nuclear cross sections are needed to improve the codes. Energy deposition in biological molecules and related effects should also be developed to achieve accurate risk models for long-term exploratory missions. Passive shielding can be effective for solar particle events; however, it is limited for galactic cosmic rays (GCR). Active shielding would have to overcome challenging technical hurdles to protect against GCR. Thus, improved risk assessment and genetic and biomedical approaches are a more likely solution to GCR radiation protection issues.

Journal ArticleDOI
TL;DR: In this article, the authors used an improved treatment of the three-nucleon force (3NF) contribution that includes a corrected combinatorial factor beyond Hartree-Fock that was omitted in previous nuclear matter calculations.
Abstract: We present nuclear matter calculations based on low-momentum interactions derived from chiral effective field theory potentials. The current calculations use an improved treatment of the three-nucleon force (3NF) contribution that includes a corrected combinatorial factor beyond Hartree-Fock that was omitted in previous nuclear matter calculations. We find realistic saturation properties using parameters fit only to few-body data, but with larger uncertainty estimates from cutoff dependence and the 3NF parametrization than in previous calculations.

Journal ArticleDOI
TL;DR: A comprehensive review on the latest development of the antiferroelectric ↔ ferroelectric phase transition is presented in this paper, where the electric field-induced Antifroelectric-to-Ferroelectric transition is a key to the poling process to develop piezoelectricity in morphotropic phase boundary (MPB) compositions.
Abstract: A comprehensive review on the latest development of the antiferroelectric ↔ ferroelectric phase transition is presented. The abrupt volume expansion and sudden development of polarization at the phase transition has been extensively investigated in PbZrO3-based perovskite ceramics. New research developments in these compositions, including the incommensurate domain structure, the auxetic behavior under electric fields in the induced ferroelectric phase, the ferroelastic behavior of the multicell cubic phase, the impact of radial compression, the unexpected electric field-induced ferroelectric-to-antiferroelectric transition, and the phase transition mechanical toughening effect have been summarized. Due to their significance to leadfree piezoelectric ceramics, compounds with antiferroelectric phases, including NaNbO3, AgNbO3, and (Bi1/2Na1/2)TiO3, are also critically reviewed. Focus has been placed on the (Bi1/2Na1/2)TiO3–BaTiO3 solid solution where the electric field-induced ferroelectric phase remains even after the applied field is removed at room temperature. Therefore, the electric field-induced antiferroelectric-to-ferroelectric phase transition is a key to the poling process to develop piezoelectricity in morphotropic phase boundary (MPB) compositions. The competing phase transition and domain switching processes in 0.93 (Bi1/2Na1/2)TiO3–0.07BaTiO3 are directly imaged with nanometer resolution using the unique in situ transmission electron microscopy (TEM) technique.

Journal ArticleDOI
TL;DR: In this article, the authors performed in-situ measurements of volcanic ash plumes over Europe between Southern Germany and Iceland with the Falcon aircraft during the eruption period of the Eyjafjalla volcano between 19 April and 18 May 2010.
Abstract: . Airborne lidar and in-situ measurements of aerosols and trace gases were performed in volcanic ash plumes over Europe between Southern Germany and Iceland with the Falcon aircraft during the eruption period of the Eyjafjalla volcano between 19 April and 18 May 2010. Flight planning and measurement analyses were supported by a refined Meteosat ash product and trajectory model analysis. The volcanic ash plume was observed with lidar directly over the volcano and up to a distance of 2700 km downwind, and up to 120 h plume ages. Aged ash layers were between a few 100 m to 3 km deep, occurred between 1 and 7 km altitude, and were typically 100 to 300 km wide. Particles collected by impactors had diameters up to 20 μm diameter, with size and age dependent composition. Ash mass concentrations were derived from optical particle spectrometers for a particle density of 2.6 g cm−3 and various values of the refractive index (RI, real part: 1.59; 3 values for the imaginary part: 0, 0.004 and 0.008). The mass concentrations, effective diameters and related optical properties were compared with ground-based lidar observations. Theoretical considerations of particle sedimentation constrain the particle diameters to those obtained for the lower RI values. The ash mass concentration results have an uncertainty of a factor of two. The maximum ash mass concentration encountered during the 17 flights with 34 ash plume penetrations was below 1 mg m−3. The Falcon flew in ash clouds up to about 0.8 mg m−3 for a few minutes and in an ash cloud with approximately 0.2 mg m−3 mean-concentration for about one hour without engine damage. The ash plumes were rather dry and correlated with considerable CO and SO2 increases and O3 decreases. To first order, ash concentration and SO2 mixing ratio in the plumes decreased by a factor of two within less than a day. In fresh plumes, the SO2 and CO concentration increases were correlated with the ash mass concentration. The ash plumes were often visible slantwise as faint dark layers, even for concentrations below 0.1 mg m−3. The large abundance of volatile Aitken mode particles suggests previous nucleation of sulfuric acid droplets. The effective diameters range between 0.2 and 3 μm with considerable surface and volume contributions from the Aitken and coarse mode aerosol, respectively. The distal ash mass flux on 2 May was of the order of 500 (240–1600) kg s−1. The volcano induced about 10 (2.5–50) Tg of distal ash mass and about 3 (0.6–23) Tg of SO2 during the whole eruption period. The results of the Falcon flights were used to support the responsible agencies in their decisions concerning air traffic in the presence of volcanic ash.

Journal ArticleDOI
TL;DR: In the field of scanned beam delivery, the report focuses on the results of research on countermeasures of the interference effect and clinical application of these techniques can be expected in the near future.
Abstract: Charged particle beam radiotherapy requires dedicated measures to compensate for the dosimetric influence of inter- and intra-fractional target motion. Independent of the delivery technique, these measures have to incorporate the strong influence of the radiological depth on the delivered dose. For scanned beam delivery, interference effects of target motion and scanned beam can further cause under-dosage of the clinical target volume despite using margins. Within the scope of this review, published data with respect to motion management in scattered as well as scanned beam treatment delivery will be summarized. Based on a section covering the dosimetric impact of organ motion, motion management during treatment planning, patient positioning, treatment delivery and treatment validation will be summarized. For scattered beam delivery, the concepts and data are often based on clinical usage since treatment of moving tumors has been performed for several years. In the field of scanned beam delivery, the report focuses on the results of research on countermeasures of the interference effect. Clinical application of these techniques can be expected in the near future.

Proceedings ArticleDOI
22 Mar 2011
TL;DR: This paper presents a tool, ROPdefender, that dynamically detects conventional ROP attacks (that are based on return instructions) and can be immediately deployed by end-users, since it does not rely on side information which is rarely provided in practice.
Abstract: Modern runtime attacks increasingly make use of the powerful return-oriented programming (ROP) attack techniques and principles such as recent attacks on Apple iPhone and Acrobat products to name some. These attacks even work under the presence of modern memory protection mechanisms such as data execution prevention (DEP). In this paper, we present our tool, ROPdefender, that dynamically detects conventional ROP attacks (that are based on return instructions). In contrast to existing solutions, ROPdefender can be immediately deployed by end-users, since it does not rely on side information (e.g., source code or debugging information) which are rarely provided in practice. Currently, our tool adds a runtime overhead of 2x which is comparable to similar instrumentation-based tools.

Journal ArticleDOI
TL;DR: This work demonstrates that H2AX is early phosphorylated within HC, but the damage site is subsequently expelled from the center to the periphery of chromocenters within ∼20 min, and describes a local decondensation of HC at the sites of ion hits, potentially allowing for DSB movement via physical forces.
Abstract: DNA double-strand breaks (DSBs) can induce chromosomal aberrations and carcinogenesis and their correct repair is crucial for genetic stability. The cellular response to DSBs depends on damage signaling including the phosphorylation of the histone H2AX (γH2AX). However, a lack of γH2AX formation in heterochromatin (HC) is generally observed after DNA damage induction. Here, we examine γH2AX and repair protein foci along linear ion tracks traversing heterochromatic regions in human or murine cells and find the DSBs and damage signal streaks bending around highly compacted DNA. Given the linear particle path, such bending indicates a relocation of damage from the initial induction site to the periphery of HC. Real-time imaging of the repair protein GFP-XRCC1 confirms fast recruitment to heterochromatic lesions inside murine chromocenters. Using single-ion microirradiation to induce localized DSBs directly within chromocenters, we demonstrate that H2AX is early phosphorylated within HC, but the damage site is subsequently expelled from the center to the periphery of chromocenters within ∼20 min. While this process can occur in the absence of ATM kinase, the repair of DSBs bordering HC requires the protein. Finally, we describe a local decondensation of HC at the sites of ion hits, potentially allowing for DSB movement via physical forces.

01 Jun 2011
TL;DR: This work focuses on the classical Gilbert-Elliott model whose second order statistics is derived over arbitrary time scales and used to fit packet loss processes of traffic traces measured in the IP backbone of Deutsche Telekom.
Abstract: The estimation of quality for real-time services over telecommunication networks requires realistic models for impairments and failures during transmission. We focus on the classical Gilbert-Elliott model whose second order statistics is derived over arbitrary time scales and used to fit packet loss processes of traffic traces measured in the IP backbone of Deutsche Telekom. The results show that simple Markov models are appropriate to capture the observed loss pattern.

Journal ArticleDOI
TL;DR: In this paper, the authors comprehensively review the present level of understanding for such impact situations, by considering effects introduced by morphological changes to the surface and by changes of the wettability.
Abstract: Drop impact onto surfaces has long been a popular and important subject of experimental, numerical and theoretical studies to explain phenomena observed both in nature and in many engineering applications. Progress in understanding and describing the hydrodynamics involved in drop impacts has been rapid in recent years, due partly to the availability of high-speed cameras, but also because of accompanying advances in theoretical and numerical approaches. Thus, for simple surfaces, i.e. smooth surfaces of uniform chemistry, the outcome of a drop impact can be well predicted over a large range of impact parameters, including quantitative values of spread dynamics and splash characteristics. This article comprehensively reviews the present level of understanding for such impact situations. However many practical applications involve impacts onto surfaces of higher complexity, either morphologically or chemically, involving textured or porous surfaces or surfaces with non-uniform wettability characteristics. This expands greatly the parameter space for which descriptions of the impact must be found and the present understanding is significantly more rudimentary compared to drop impacts onto simple surfaces. In this review such impacts are discussed by considering effects introduced by morphological changes to the surface and by changes of the wettability. Comparisons to corresponding impacts onto simple surfaces are drawn to underline the additional physical mechanisms that must be considered.

Journal ArticleDOI
K. Aamodt1, N. Abel2, U. Abeysekara3, A. Abrahantes Quintana  +1054 moreInstitutions (74)
15 Jun 2011
TL;DR: In this article, the authors used the specific energy loss in the inner tracking silicon detector and the time projection chamber to identify hadrons at higher momenta, and the distinctive kink topology of the weak decay of charged kaons was used for an alternative measurement of the kaon transverse momentum (pt) spectra.
Abstract: The production of π+, π−, K+, K−, p, and \(\overline{\mathrm{p}}\) at mid-rapidity has been measured in proton-proton collisions at \(\sqrt{s} = 900~\mathrm{GeV}\) with the ALICE detector. Particle identification is performed using the specific energy loss in the inner tracking silicon detector and the time projection chamber. In addition, time-of-flight information is used to identify hadrons at higher momenta. Finally, the distinctive kink topology of the weak decay of charged kaons is used for an alternative measurement of the kaon transverse momentum (pt) spectra. Since these various particle identification tools give the best separation capabilities over different momentum ranges, the results are combined to extract spectra from pt=100 MeV/c to 2.5 GeV/c. The measured spectra are further compared with QCD-inspired models which yield a poor description. The total yields and the mean pt are compared with previous measurements, and the trends as a function of collision energy are discussed.

Journal ArticleDOI
TL;DR: Environmental warming generally increases the direct short-term per capita interaction strengths between predators and their prey as described by functional-response models, which implies that warming of natural ecosystems may dampen predator–prey oscillations thus stabilizing their dynamics.
Abstract: Predictions on the consequences of the rapidly increasing atmospheric CO2 levels and associated climate warming for population dynamics, ecological community structure and ecosystem functioning depend on mechanistic energetic models of temperature effects on populations and their interactions. However, such mechanistic approaches combining warming effects on metabolic (energy loss of organisms) and feeding rates (energy gain by organisms) remain a key, yet elusive, goal. Aiming to fill this void, we studied the metabolic rates and functional responses of three differently sized, predatory ground beetles on one mobile and one more resident prey species across a temperature gradient (5, 10, 15, 20, 25 and 30 °C). Synthesizing metabolic and functional-response theory, we develop novel mechanistic predictions how predator–prey interaction strengths (i.e., functional responses) should respond to warming. Corroborating prior theory, warming caused strong increases in metabolism and decreases in handling time. Consistent with our novel model, we found increases in predator attack rates on a mobile prey, whereas attack rates on a mostly resident prey remained constant across the temperature gradient. Together, these results provide critically important information that environmental warming generally increases the direct short-term per capita interaction strengths between predators and their prey as described by functional-response models. Nevertheless, the several fold stronger increase in metabolism with warming caused decreases in energetic efficiencies (ratio of per capita feeding rate to metabolic rate) for all predator–prey interactions. This implies that warming of natural ecosystems may dampen predator–prey oscillations thus stabilizing their dynamics. The severe long-term implications; however, include predator starvation due to energetic inefficiency despite abundant resources.