Technische Universität Darmstadt

About: Technische Universität Darmstadt is a education organization based out in Darmstadt, Germany. It is known for research contribution in the topics: Computer science & Context (language use). The organization has 17316 authors who have published 40619 publications receiving 937916 citations. The organization is also known as: Darmstadt University of Technology & University of Darmstadt.

An Ant Approach to the Flow Shop Problem

Abstract: In this article we present an Ant Colony Optimization approach to the Flow Shop Problem. ACO is a new algorithmic approach, inspired by the foraging behavior of real ants, that can be applied to the solution of combinatorial optimization problems. Artificial ants are used to construct solutions for Flow Shop Problems that subsequently are improved by a local search procedure. Comparisons with other heuristics for the Flow Shop Scheduling problem show that with our approach very promising results are obtained.

Carbon nanotubes as emerging quantum-light sources

Abstract: Progress in quantum computing and quantum cryptography requires efficient, electrically triggered, single-photon sources at room temperature in the telecom wavelengths. It has been long known that semiconducting single-wall carbon nanotubes (SWCNTs) display strong excitonic binding and emit light over a broad range of wavelengths, but their use has been hampered by a low quantum yield and a high sensitivity to spectral diffusion and blinking. In this Perspective, we discuss recent advances in the mastering of SWCNT optical properties by chemistry, electrical contacting and resonator coupling towards advancing their use as quantum light sources. We describe the latest results in terms of single-photon purity, generation efficiency and indistinguishability. Finally, we consider the main fundamental challenges stemming from the unique properties of SWCNTs and the most promising roads for SWCNT-based chip integrated quantum photonic sources. This Perspective describes the recent advances in understanding and controlling the properties of single-wall carbon nanotubes as well as the progress towards the fabrication of new electrically driven single-photon sources.

Dead reckoning from the pocket - An experimental study

Abstract: Modern mobile phones enable absolute positioning based on GPS or WiFi. However, incremental positioning based on dead reckoning is an interesting source of complementary information, e.g., for indoor positioning or for filling in reception gaps. In the literature however, reasonable dead reckoning accuracies have been reported for fixed and typically a priori known device placements only, e.g., on the hip. Therefore, this paper contributes an experimental study of several published as well as novel approaches for dead reckoning in a scenario with unconstrained placement of a device in the user's trouser pockets. Utilizing the movement of a sensor in a trouser pocket due to body motion, we estimate the user's walking direction and steps robustly for arbitrary placements in the pocket and without additional body-worn sensors. We evaluate these methods on a large dataset of 23 traces of 8 different persons, and compare different approaches.

Covalent Attachment of Cyclic TAT Peptides to GFP Results in Protein Delivery into Live Cells with Immediate Bioavailability

Abstract: The delivery of free molecules into the cytoplasm and nucleus by using arginine-rich cell-penetrating peptides (CPPs) has been limited to small cargoes, while large cargoes such as proteins are taken up and trapped in endocytic vesicles. Based on recent work, in which we showed that the transduction efficiency of arginine-rich CPPs can be greatly enhanced by cyclization, the aim was to use cyclic CPPs to transport full-length proteins, in this study green fluorescent protein (GFP), into the cytosol of living cells. Cyclic and linear CPP-GFP conjugates were obtained by using azido-functionalized CPPs and an alkyne-functionalized GFP. Our findings reveal that the cyclic-CPP-GFP conjugates are internalized into live cells with immediate bioavailability in the cytosol and the nucleus, whereas linear CPP analogues do not confer GFP transduction. This technology expands the application of cyclic CPPs to the efficient transport of functional full-length proteins into live cells.