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Institution

Technische Universität Darmstadt

EducationDarmstadt, Germany
About: Technische Universität Darmstadt is a education organization based out in Darmstadt, Germany. It is known for research contribution in the topics: Neutron & Finite element method. The organization has 17316 authors who have published 40619 publications receiving 937916 citations. The organization is also known as: Darmstadt University of Technology & University of Darmstadt.


Papers
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Journal ArticleDOI
TL;DR: It is found that recombinant human CtIP exhibits 5' flap endonuclease activity on branched DNA structures, independent of the MRN complex, suggesting that the nucleaseActivity of CtIP is specifically required for the removal of DNA adducts at sites of DNA breaks.

173 citations

Journal ArticleDOI
TL;DR: In this paper, a vibrating surface driven by an electromagnetic turbulator was mounted in a flat plate to excite the Tollmien-Schlichting (TS) waves and these were amplified by an adverse pressure gradient induced by an insert on the upper wall of the test section.
Abstract: In the present work artificially excited Tollmien–Schlichting (TS) waves were cancelled using plasma actuators operated in pulsed mode. In order to achieve this a vibrating surface driven by an electromagnetic turbulator was flush mounted in a flat plate to excite the TS waves. These were amplified by an adverse pressure gradient induced by an insert on the upper wall of the test section. A control plasma actuator positioned downstream of the excitation actuator attenuates the waves by imparting an unsteady force into the boundary layer to counteract the oscillation. As a result the amplitude of the velocity fluctuations at the excitation frequency is reduced significantly depending on the distance from the wall. A parameter study was performed to identify the influence of several operation parameters of the control actuator.

172 citations

Journal ArticleDOI
TL;DR: It is shown that the lack of hemodynamic forces triggers apoptosis in endothelial cells, hinting at mechanical forces as essential stimuli for the maintenance of blood vessels.

172 citations

Journal ArticleDOI
TL;DR: Some new stochastic Runge-Kutta (SRK) methods for the strong approximation of solutions of Stochastic differential equations (SDEs) with improved efficiency are introduced and their convergence is proved by applying multicolored rooted tree analysis.
Abstract: Some new stochastic Runge-Kutta (SRK) methods for the strong approximation of solutions of stochastic differential equations (SDEs) with improved efficiency are introduced. Their convergence is proved by applying multicolored rooted tree analysis. Order conditions for the coefficients of explicit and implicit SRK methods are calculated. As the main novelty, order 1.0 strong SRK methods with significantly reduced computational complexity for Ito as well as for Stratonovich SDEs with a multidimensional driving Wiener process are presented where the number of stages is independent of the dimension of the Wiener process. Further, an order 1.0 strong SRK method customized for Ito SDEs with commutative noise is introduced. Finally, some order 1.5 strong SRK methods for SDEs with scalar, diagonal, and additive noise are proposed. All introduced SRK methods feature significantly reduced computational complexity compared to well-known schemes.

172 citations

Journal ArticleDOI
TL;DR: The MLPs provide substantive credence to the view, that not only the amylose-iodine complex formation is mediated to an essential degree by hydrophobic attractions at the guest-host interface, but that the same factors determine the stability of this unique supramolecular assembly.
Abstract: Two polymorphs of amylose, the native double-helical A-form and the single-stranded V H counterpart, as well as the amylose polyiodide complex were subjected to a molecular modeling study. Based on their X-ray diffraction-derived structures, the solvent-accessible' contact surfaces were generated, onto which the computed molecular lipophilicity profiles (MLPs) were projected in color-coded form, easily allowing to locate hydrophobic and hydrophilic surface regions. Their detailed analysis revealed the double-stranded A-form to be a rather compact structure with an irregular distribution of hydrophilic and hydrophobic regions over the entire outer surface, with the interior of the double helix being inaccessible even for small molecules. By contrast, V H -amylose, in accord with its water solubility, has a pronouncedly hydrophilic outside surface with an as distinctly hydrophobic channel. - In the dark-blue amylose-polyiodide complex, the hydrophobic channel of the single-helical V H -form serves as a well-ordered matrix for incorporation and alignment of the iodine-iodide species to elaborate a linear polyiodide chain in a nearly perfect steric fit and in full complementarity of hydrophobic regions of guest and host. Thus, the MLPs provide substantive credence to the view, that not only the amylose-iodine complex formation is mediated to an essential degree by hydrophobic attractions at the guest-host interface, but that the same factors determine the stability of this unique supramolecular assembly.

172 citations


Authors

Showing all 17627 results

NameH-indexPapersCitations
Yang Gao1682047146301
Herbert A. Simon157745194597
Stephen Boyd138822151205
Jun Chen136185677368
Harold A. Mooney135450100404
Bernt Schiele13056870032
Sascha Mehlhase12685870601
Yuri S. Kivshar126184579415
Michael Wagner12435154251
Wolf Singer12458072591
Tasawar Hayat116236484041
Edouard Boos11675764488
Martin Knapp106106748518
T. Kuhl10176140812
Peter Braun-Munzinger10052734108
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023135
2022624
20212,462
20202,585
20192,609
20182,493