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Institution

Technische Universität Darmstadt

EducationDarmstadt, Germany
About: Technische Universität Darmstadt is a education organization based out in Darmstadt, Germany. It is known for research contribution in the topics: Neutron & Finite element method. The organization has 17316 authors who have published 40619 publications receiving 937916 citations. The organization is also known as: Darmstadt University of Technology & University of Darmstadt.


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Journal ArticleDOI
TL;DR: It is shown that in G2, as in G1, NHEJ represents the major DSB‐repair pathway whereas HR is only essential for repair of ∼15% of X‐ or γ‐ray‐induced DSBs.
Abstract: Homologous recombination (HR) and non-homologous end joining (NHEJ) represent distinct pathways for repairing DNA double-strand breaks (DSBs). Previous work implicated Artemis and ATM in an NHEJ-dependent process, which repairs a defined subset of radiation-induced DSBs in G1-phase. Here, we show that in G2, as in G1, NHEJ represents the major DSB-repair pathway whereas HR is only essential for repair of ∼15% of X- or γ-ray-induced DSBs. In addition to requiring the known HR proteins, Brca2, Rad51 and Rad54, repair of radiation-induced DSBs by HR in G2 also involves Artemis and ATM suggesting that they promote NHEJ during G1 but HR during G2. The dependency for ATM for repair is relieved by depleting KAP-1, providing evidence that HR in G2 repairs heterochromatin-associated DSBs. Although not core HR proteins, ATM and Artemis are required for efficient formation of single-stranded DNA and Rad51 foci at radiation-induced DSBs in G2 with Artemis function requiring its endonuclease activity. We suggest that Artemis endonuclease removes lesions or secondary structures, which inhibit end resection and preclude the completion of HR or NHEJ.

512 citations

Journal ArticleDOI
TL;DR: Biodiversity loss explained indirect effects in a region of intermediate productivity and was most damaging when land‐use objectives favoured supporting and cultural services, and functional composition shifts, towards fast‐growing plant species, strongly increased provisioning services in more inherently unproductive grasslands.
Abstract: Global change, especially land-use intensification, affects human well-being by impacting the delivery of multiple ecosystem services (multifunctionality). However, whether biodiversity loss is a major component of global change effects on multifunctionality in real-world ecosystems, as in experimental ones, remains unclear. Therefore, we assessed biodiversity, functional composition and 14 ecosystem services on 150 agricultural grasslands differing in land-use intensity. We also introduce five multifunctionality measures in which ecosystem services were weighted according to realistic land-use objectives. We found that indirect land-use effects, i.e. those mediated by biodiversity loss and by changes to functional composition, were as strong as direct effects on average. Their strength varied with land-use objectives and regional context. Biodiversity loss explained indirect effects in a region of intermediate productivity and was most damaging when land-use objectives favoured supporting and cultural services. In contrast, functional composition shifts, towards fast-growing plant species, strongly increased provisioning services in more inherently unproductive grasslands.

507 citations

Journal ArticleDOI
TL;DR: In this article, changes in annual, June-September and March-May rainfall and rainy days have been analyzed based on 11 key stations located in different climatic zones of Ethiopia over the common period 1965-2002.
Abstract: Changes in annual, June–September and March–May rainfall and rainy days herein (defined as a day with rainfall greater than 1 mm) have been analysed based on 11 key stations located in different climatic zones of Ethiopia over the common period 1965–2002. The progressive Mann–Kendall trend test shows that there is no trend in the annual rainfall total, the seasonal rainfall total or rainy days over central, northern and northwestern Ethiopia in the period 1965–2002. In contrast, the annual and the June–September total rainfalls for the eastern (Jijiga, 137 mm/decade), southern (Negele, 119 mm/decade) and southwestern (Gore 257 mm/decade) stations show a significant decline since about 1982. Correlation analysis shows that the decline of rainfall in eastern, south and southwestern Ethiopia is caused by the corresponding persistent warming of the South Atlantic Ocean over the period approximately from 1986 to 2002. The sea-surface temperature (SST) over the tropical eastern Pacific Ocean is not significantly correlated with the main rainfall of the semi-arid lowland areas of eastern, southern, and southwestern Ethiopia, except at marginal zones in transition to the Ethiopian Highlands. June–September rainfall over the Ethiopian Highlands is positively correlated to the equatorial east Pacific sea-level pressure and the southern oscillation index, and negatively correlated to SST over the tropical eastern Pacific Ocean as expected, confirming again that warm El Nino–southern oscillation episodes are associated with below-average June–September rainfall over the Ethiopian Highlands. Copyright © 2004 Royal Meteorological Society

504 citations

Journal ArticleDOI
TL;DR: The parameters in greatest need of additional measurements are S(c), mesophyll cell wall thickness, and the permeabilities of the plasma membrane and chloroplast envelope.
Abstract: CO2 faces a series of resistances while diffusing between the substomatal cavities and the sites of carboxylation within chloroplasts. The absence of techniques to measure the resistance of individual steps makes it difficult to define their relative importance. Resistance to diffusion through intercellular airspace differs between leaves, but is usually of minor importance. Leaves with high photosynthetic capacity per unit leaf area reduce mesophyll resistance by increasing the surface area of chloroplasts exposed to intercellular airspace per unit leaf area, Sc. Cell walls impose a significant resistance. Assuming an effective porosity of the cell wall of 0.1 or 0.05, then cell walls could account for 25% or 50% of the total mesophyll resistance, respectively. Since the fraction of apoplastic water that is unbound and available for unhindered CO2 diffusion is unknown, it is possible that the effective porosity is 50% of the total resistance and a variable proportion. Most of the remaining resistance is imposed by one or more of the three membranes as mesophyll resistance can be altered by varying the expression of cooporins. The CO2 permeability of vesicles prepared from chloroplast envelopes has been reduced by RNA interference (RNAi) expression of NtAQP1, but not those prepared from the plasma membrane. Carbonic anhydrase activity also influences mesophyll resistance. Mesophyll resistance is relatively insensitive to the manipulation of any step in the pathway because it represents only part of the total and may also be countered by pleiotropic compensatory changes. The parameters in greatest need of additional measurements are Sc, mesophyll cell wall thickness, and the permeabilities of the plasma membrane and chloroplast envelope.

498 citations

Proceedings ArticleDOI
01 Jun 2017
TL;DR: IoT Sentinel is presented, a system capable of automatically identifying the types of devices being connected to an IoT network and enabling enforcement of rules for constraining the communications of vulnerable devices so as to minimize damage resulting from their compromise.
Abstract: With the rapid growth of the Internet-of-Things (IoT), concerns about the security of IoT devices have become prominent. Several vendors are producing IP-connected devices for home and small office networks that often suffer from flawed security designs and implementations. They also tend to lack mechanisms for firmware updates or patches that can help eliminate security vulnerabilities. Securing networks where the presence of such vulnerable devices is given, requires a brownfield approach: applying necessary protection measures within the network so that potentially vulnerable devices can coexist without endangering the security of other devices in the same network. In this paper, we present IoT Sentinel, a system capable of automatically identifying the types of devices being connected to an IoT network and enabling enforcement of rules for constraining the communications of vulnerable devices so as to minimize damage resulting from their compromise. We show that IoT Sentinel is effective in identifying device types and has minimal performance overhead.

498 citations


Authors

Showing all 17627 results

NameH-indexPapersCitations
Yang Gao1682047146301
Herbert A. Simon157745194597
Stephen Boyd138822151205
Jun Chen136185677368
Harold A. Mooney135450100404
Bernt Schiele13056870032
Sascha Mehlhase12685870601
Yuri S. Kivshar126184579415
Michael Wagner12435154251
Wolf Singer12458072591
Tasawar Hayat116236484041
Edouard Boos11675764488
Martin Knapp106106748518
T. Kuhl10176140812
Peter Braun-Munzinger10052734108
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023135
2022624
20212,462
20202,585
20192,609
20182,493