Tehran University of Medical Sciences

About: Tehran University of Medical Sciences is a education organization based out in Tehran, Iran. It is known for research contribution in the topics: Population & Cancer. The organization has 35661 authors who have published 57234 publications receiving 878523 citations. The organization is also known as: TUMS.

Screening of the adult population in Iran for coeliac disease: comparison of the tissue-transglutaminase antibody and anti-endomysial antibody tests.

Abstract: Background and aimsPopulation-based studies for the prevalence of coeliac disease (CD) in west-Asian countries are scarce. We aimed to determine the prevalence of gluten-sensitive enteropathy (GSE) in the general population of northern and southern Iran, and evaluate the sensitivity and specificity

Cytokine imbalance in irritable bowel syndrome: a systematic review and meta-analysis.

Abstract: Background Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder of unknown etiology; although infection and inflammation have recently been considered as important etiologic agents. A recent meta-analysis showed correlations between cytokine [interleukin-10 (IL-10) and tumor necrosis factor (TNF)] gene polymorphisms and IBS; however, it is still unknown whether patients with IBS have different cytokine profiles compared to healthy population. Methods To determine the relationships between serum/plasma levels or mucosal expression of IL-10/TNF-α and IBS, we conducted a systematic review and meta-analysis based on case–control studies retrieved from PubMed and EMBASE search through August 2013. Standardized mean difference (SMD) was generated by using the inverse variance method. Heterogeneity was assessed based on I2 values. Key Results Serum/plasma levels of TNF-α tended to be higher in IBS vs controls (p = 0.09); this reached significance in IBS subtypes vs controls and in female patients with IBS. However, serum/plasma levels of IL-10 were not significantly different in IBS patients vs controls. Further analysis of serum/plasma IL-10 levels in IBS subtypes did not show any difference; however, analysis based on gender showed a significantly lower serum/plasma IL-10 levels in male patients with IBS vs male controls (p = 0.02). Colonic IL-10 mRNA had a significantly lower expression in IBS vs control (p = 0.001). Conclusions & Inferences There is an imbalance of proinflammatory TNF-α, and anti-inflammatory IL-10, cytokines in IBS. Stratifying IBS patients based on cytokine profile may represent an opportunity for personalized treatment of this condition.

Prevalence of overweight and obesity in adolescent Tehrani students, 2000-2001: an epidemic health problem.

Abstract: Department of Community Nutrition,Faculty of Nutrition Sciences and Food Technology, Shaheed Beheshti University of Medical Sciences and HealthServices, Tehran, IranSubmitted 28 April 2003: Accepted 1 December 2003AbstractObjective: Overweight has become a public health problem in most developingcountries. Evidence suggests that adolescence is a critical period in determiningadulthood obesity and its complications. The present study was carried out to assessthe prevalence of overweight and obesity among secondary school students.Design and setting: This descriptive study was conducted in Tehran city, 2000–2001.Body weight and height were measured and body mass index (BMI) valueswere calculated. Underweight, overweight and obesity were defined as ,5th, $85thand $95th percentile, respectively, of age- and sex-specific BMI values fromthe National Center for Health Statistics/Centers for Disease Control andPrevention (2000).Subjects: Using a multistage sampling method, 2321 students (1068 males and 1253females) aged 11–16 years were assessed in Tehran, the capital city of Iran.Results: The overall prevalences of overweight and obesity were 21.1 and 7.8%,respectively. The prevalence of overweight among girl students (i.e. 23.1%;95% confidence interval (CI) 20.8–25.4) was significantly higher than that amongboys (i.e. 18.8%; 95% CI 16.5–21.1, P ¼ 0.01) even after adjustment for age(odds ratio 1.26, 95% CI 1.03–1.55, P ¼ 0.02). No significant risk of obesityassociated with age was found in girls or boys. In both sexes, median values ofage-specific BMI in this study were statistically higher than corresponding valuescollected in Tehrani adolescents 10 years ago (P ¼ 0.03). Similarly, a significantdifference was seen between girl students in this study and the referencepopulation (P ¼ 0.03).Conclusion: According to this study, overweight, especially in girls, should beconsidered an epidemic health problem among adolescent students in Tehran.KeywordsAdolescenceOverweightObesityTehranOverweight, as a main feature of epidemiologicaltransition, has increased in most developing countriesover the last two decades