Tehran University of Medical Sciences

About: Tehran University of Medical Sciences is a education organization based out in Tehran, Iran. It is known for research contribution in the topics: Population & Medicine. The organization has 35661 authors who have published 57234 publications receiving 878523 citations. The organization is also known as: TUMS.

Nanoparticle and Protein Corona

Abstract: Nanoparticles and other nanomaterials are increasingly considered for use in biomedical applications such as imaging, drug delivery, and hyperthermic therapies. Thus, understanding the interaction of nanomaterials with biological systems becomes key for their safe and efficient application. It is increasingly being accepted that the surface of nanomaterials would be covered by protein corona upon their entrance to the biological medium. The biological medium will then see the achieved modified surface of nanomaterials, and therefore further cellular/tissue responses depend on the composition of corona. In this chapter, we describe the corona variations according to the physicochemical properties of nanomaterials (e.g., size, shape, surface charge, surface functional groups, and hydrophilicity/hydrophobicity). Besides the nanomaterials’ effects, the role of environment factors, such as protein source and slight temperature variations, is discussed in details.

Human and animal fascioliasis in mazandaran province, northern iran

Abstract: The fascioliasis situation in humans and livestock of Iranian Mazandaran is analysed for the first time. Coprological studies showed 7.3% and 25.4% global prevalences in sheep and cattle, respectively. Studies in slaughterhouses indicate that sheep and cattle may be the main reservoir species, buffaloes may play local roles in the transmission, and goats and horses probably only participate sporadically. Morphometric studies by computer image analysis showed that forms intermediate between Fasciola hepatica and F. gigantica appear in addition to both species. A total of 107 infected humans were diagnosed during the 1999-2002 period, which suggests that fascioliasis may be widespread. The absence of differences in human fascioliasis among gender and age groups differs from other human endemic areas. Both human and animal infections show marked differences between western and eastern Mazandaran. Traditions in herbal condiments for human consumption, methods of animal husbandry and annual rainfall may explain the higher prevalences in western Mazandaran.