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Institution

Tehran University of Medical Sciences

EducationTehran, Iran
About: Tehran University of Medical Sciences is a education organization based out in Tehran, Iran. It is known for research contribution in the topics: Population & Cancer. The organization has 35661 authors who have published 57234 publications receiving 878523 citations. The organization is also known as: TUMS.


Papers
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Journal ArticleDOI
TL;DR: The VANCO-loaded silk fibroin nanoparticles entrapped in scaffolds reduced bone infections at the defected site with better outcomes than the other treatment groups, and the delivery system with good biocompatibility and sustained release properties would be appropriate for further study in the context of osteomyelitis disease.
Abstract: The successful treatment of bone infections is a major challenge in the field of orthopedics. There are some common methods for treating bone infections, including systemic antibiotic administration, local nondegradable drug vehicles, and surgical debridement, and each of these approaches has advantages and disadvantages. In the present study, the antibiotic vancomycin (VANCO) was loaded in silk fibroin nanoparticles (SFNPs) and the complexes were then entrapped in silk scaffolds to form sustained drug delivery systems. The release kinetics of VANCO from SFNPs alone and when the SFNPs were entrapped in silk scaffolds were assessed at two different pH values, 4.5 and 7.4, that affected the release profiles of VANCO. Disk diffusion tests performed with pathogens causing osteomyelitis methicillin-resistant Staphylococcus aureus (MRSA) showed antibacterial activity of the released drug at two different pH values. Additionally, injection of 8 × 106 CFU MRSA in rat’s tibia induced severe osteomyelitis disease. ...

118 citations

Journal ArticleDOI
TL;DR: The fluorescent probe exhibits high selectivity over other common metal ions, and the proposed fluorescent sensor was applied to determine zinc in water samples and waste water.

118 citations

Journal Article
TL;DR: It seems that CUS is superior to CXR in detection of pneumothorax, even after adjusting for possible sources of heterogeneity.
Abstract: Background: Early detection of pneumothorax is critically important. Several studies have shown that chest ultrasonography (CUS) is a highly sensitive and specific tool. The present systematic review and meta-analysis was designed to evaluate the diagnostic accuracy of CUS and chest radiography (CXR) for detection of pneumothorax. Materials and Methods: The literature search was conducted using PubMed, EMBASE, Cochrane, CINAHL, SUMSearch, Trip databases, and review article references. Eligible articles were defined as diagnostic studies on patients suspected for pneumothorax who underwent chest computed tomography (CT) scan and those assessing the screening role of CUS and CXR. Results: The analysis showed the pooled sensitivity and specificity of CUS were 0.87 (95% CI: 0.81-0.92; I2= 88.89, P<0.001) and 0.99 (95% CI: 0.98-0.99; I2= 86.46, P<0.001), respectively. The pooled sensitivity and specificity of CXR were 0.46 (95% CI: 0.36-0.56; I2= 85.34, P<0.001) and 1.0 (95% CI: 0.99-1.0; I2= 79.67, P<0.001), respectively. The Meta regression showed that the sensitivity (0.88; 95% CI: 0.82 - 0.94) and specificity (0.99; 95% CI: 0.98 - 1.00) of ultrasound performed by the emergency physician was higher than by non-emergency physician. Non-trauma setting was associated with higher pooled sensitivity (0.90; 95% CI: 0.83 – 0.98) and lower specificity (0.97; 95% CI: 0.95 – 0.99). Conclusion: The present meta-analysis showed that the diagnostic accuracy of CUS was higher than supine CXR for detection of pneumothorax. It seems that CUS is superior to CXR in detection of pneumothorax, even after adjusting for possible sources of heterogeneity. Key words: Pneumothorax; Ultrasonography; Radiography; Diagnostic tests, Routine

118 citations

Journal ArticleDOI
TL;DR: The clinical effects of a number of commonly used types of herbal medicines for the treatment of Alzheimer's disease are reviewed, finding that there is a place for alternative medicine, in particular, herbal medicine.
Abstract: Alzheimer's disease (AD) is characterized by profound memory loss sufficient to interfere with social and occupational functioning. It is the most common form of dementia, affecting more than 20 million people worldwide. AD is characterized by an insidious loss of memory, associated functional decline, and behavioral disturbances. Patients may live for more than a decade after they are diagnosed with AD, making it the leading cause of disability in the elderly. The incidence of AD ranges from 1 to 4 percent of the population per year, rising from its lowest level at ages 65 to 70 years to rates that may approach 6 percent for those over the age of 85 years. The first neurotransmitter defect discovered in AD involved acetylcholine (ACh). As cholinergic function is required for short-term memory, the cholinergic deficit in AD was also believed to be responsible for much of the short-term memory deficit. Clinical drug trials in patients with AD have focused on drugs that augment levels of ACh in the brain to compensate for the loss of cholinergic function. These drugs have included ACh precursors, muscarinic agonists, nicotinic agonists, and acetylcholinesterase inhibitors. The most highly developed and successful approaches to date have employed acetylcholinestrase inhibition. Although some Food and Drug Administration-approved drugs are available for the treatment of Alzheimer's disease, the outcomes are often unsatisfactory, and there is a place for alternative medicine, in particular, herbal medicine. This paper reviews the clinical effects of a number of commonly used types of herbal medicines for the treatment of AD.

118 citations

Journal ArticleDOI
TL;DR: A microtoxicity study of the inhibition of bacterial growth showed a decrease in toxicity of the laccase-treated sulfonamide solution, and a lower K m value for STZ compared to that of SMZ confirmed a higher affinity of immobilized l Accase toward STZ.

118 citations


Authors

Showing all 35946 results

NameH-indexPapersCitations
Graeme J. Hankey137844143373
Paul D.P. Pharoah13079471338
Jerome Ritz12064447987
Reza Malekzadeh118900139272
Robert N. Weinreb117112459101
Javad Parvizi11196951075
Omid C. Farokhzad11032964226
Ali Mohammadi106114954596
Alexander R. Vaccaro102117939346
John R. Speakman9566734484
Philip J. Devereaux94443110428
Rafael Lozano94265126513
Mohammad Abdollahi90104535531
Ingmar Skoog8945828998
Morteza Mahmoudi8333426229
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023105
2022524
20216,041
20206,181
20195,322
20184,885