Institution
Temasek Polytechnic
Education•Singapore, Singapore•
About: Temasek Polytechnic is a education organization based out in Singapore, Singapore. It is known for research contribution in the topics: Proton exchange membrane fuel cell & Organizational learning. The organization has 517 authors who have published 415 publications receiving 10459 citations. The organization is also known as: Temasek Poly & Politeknik Temasek.
Topics: Proton exchange membrane fuel cell, Organizational learning, Catalysis, Battery (electricity), Homomorphic encryption
Papers published on a yearly basis
Papers
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TL;DR: Analysis of the measured data shows a high correlation between the scaffold porosity and the compressive properties based on a power-law relationship.
1,635 citations
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TL;DR: FDM allows the design and fabrication of highly reproducible bioresorbable 3D scaffolds with a fully interconnected pore network and shows that fibroblasts and osteoblast-like cells can proliferate, differentiate, and produce a cellular tissue in an entirely interconnected 3D polycaprolactone matrix.
Abstract: A number of different processing techniques have been developed to design and fabricate three-dimensional (3D) scaffolds for tissue-engineering applications. The imperfection of the current techniques has encouraged the use of a rapid prototyping technology known as fused deposition modeling (FDM). Our results show that FDM allows the design and fabrication of highly reproducible bioresorbable 3D scaffolds with a fully interconnected pore network. The mechanical properties and in vitro biocompatibility of polycaprolactone scaffolds with a porosity of 61 +/- 1% and two matrix architectures were studied. The honeycomb-like pores had a size falling within the range of 360 x 430 x 620 microm. The scaffolds with a 0/60/120 degrees lay-down pattern had a compressive stiffness and a 1% offset yield strength in air of 41.9 +/- 3.5 and 3.1 +/- 0.1 MPa, respectively, and a compressive stiffness and a 1% offset yield strength in simulated physiological conditions (a saline solution at 37 degrees C) of 29.4 +/- 4.0 and 2.3 +/- 0.2 MPa, respectively. In comparison, the scaffolds with a 0/72/144/36/108 degrees lay-down pattern had a compressive stiffness and a 1% offset yield strength in air of 20.2 +/- 1.7 and 2.4 +/- 0.1 MPa, respectively, and a compressive stiffness and a 1% offset yield strength in simulated physiological conditions (a saline solution at 37 degrees C) of 21.5 +/- 2.9 and 2.0 +/- 0.2 MPa, respectively. Statistical analysis confirmed that the five-angle scaffolds had significantly lower stiffness and 1% offset yield strengths under compression loading than those with a three-angle pattern under both testing conditions (p < or = 0.05). The obtained stress-strain curves for both scaffold architectures demonstrate the typical behavior of a honeycomb structure undergoing deformation. In vitro studies were conducted with primary human fibroblasts and periosteal cells. Light, environmental scanning electron, and confocal laser microscopy as well as immunohistochemistry showed cell proliferation and extracellular matrix production on the polycaprolactone surface in the 1st culturing week. Over a period of 3-4 weeks in a culture, the fully interconnected scaffold architecture was completely 3D-filled by cellular tissue. Our cell culture study shows that fibroblasts and osteoblast-like cells can proliferate, differentiate, and produce a cellular tissue in an entirely interconnected 3D polycaprolactone matrix.
1,361 citations
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TL;DR: The important properties of the biomaterials and the scaffold design in the making of tissue engineered bone constructs are discussed in detail, with special emphasis placed on the new material developments, namely composites made of synthetic polymers and calcium phosphates.
Abstract: Scaffold-based bone tissue engineering aims to repair/regenerate bone defects. Such a treatment concept involves seeding autologous osteogenic cells throughout a biodegradable scaffold to create a scaffold-cell hybrid that may be called a tissue-engineered construct (TEC). A variety of materials and scaffolding fabrication techniques for bone tissue engineering have been investigated over the past two decades. This review aims to discuss the advances in bone engineering from a scaffold material point of view. In the first part the reader is introduced to the basic principles of bone engineering. The important properties of the biomaterials and the scaffold design in the making of tissue engineered bone constructs are discussed in detail, with special emphasis placed on the new material developments, namely composites made of synthetic polymers and calcium phosphates. Advantages and limitations of these materials are analysed along with various architectural parameters of scaffolds important for bone tissue engineering, e.g. porosity, pore size, interconnectivity and pore-wall microstructures.
867 citations
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TL;DR: Polysaccharide major functions involved in antitumor, anti-virus, and anti-inflammatory bioactivities are described and the methods widely used in isolation and purification of polysaccharides are introduced.
297 citations
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TL;DR: In this paper, a comprehensive review about the BP materials (metallic, non-porous graphite and composite materials) and corresponding fabrication methods, flow field layouts, and PEM fuel cells applications is presented.
212 citations
Authors
Showing all 517 results
Name | H-index | Papers | Citations |
---|---|---|---|
Julian D. Marshall | 57 | 206 | 10104 |
Shabbir Moochhala | 56 | 186 | 10294 |
Kian Jon Chua | 50 | 201 | 8361 |
Christopher Marlowe A. Caipang | 34 | 72 | 2877 |
Eng Shi Ong | 29 | 52 | 2835 |
Roland K. Yeo | 24 | 64 | 1509 |
Chung Yen Ang | 24 | 40 | 1904 |
Wang Zhou | 23 | 111 | 1858 |
Subbiah Ravichandran | 21 | 101 | 1488 |
Cheng Siong Chin | 20 | 115 | 1197 |
Meng Fatt Leong | 20 | 27 | 1382 |
Ashok K. Lalwani | 18 | 43 | 1648 |
Hanhua Feng | 18 | 44 | 1311 |
Aldy Gunawan | 16 | 67 | 896 |
Lijun Liu | 16 | 23 | 1699 |