Showing papers by "Temple University published in 1975"
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01 Jan 1975TL;DR: In this article, a therapist and inspiring guide, Dr. May draws on his experience to show how we can break out of old patterns in our lives, and offers us a way through our fears into a fully realized self.
Abstract: What if imagination and art are not, as many of us might think, the frosting on life but the fountainhead of human experience? What if our logic and science derive from art forms, rather than the other way around? In this trenchant volume, Rollo May helps all of us find those creative impulses that, once liberated, offer new possibilities for achievement. A renowned therapist and inspiring guide, Dr. May draws on his experience to show how we can break out of old patterns in our lives. His insightful book offers us a way through our fears into a fully realized self.
662 citations
TL;DR: In this article, the experimentalist's familiar formula for multiple scattering is investigated in terms of the more exact theory, and a new value for the constant is suggested: Es=17.5 MeV.
425 citations
TL;DR: This paper found that popularity ratings and perceived psychological adjustment of both passive-dependent men and aggressive-assertive women were adversely affected by sex role reversals, and their findings were discussed in terms of their contribution to recent theories about women's achievement motivation.
288 citations
TL;DR: Human gingival fibroblasts were used to study the in vitro attachment of cells to the root surface of periodontally-involved teeth, and extrapolation of these data to an in vivo situation dictates that a clinical success would depend upon complete removal of toxic materials from diseased cementum or the removal of the cementum itself.
Abstract: Human gingival fibroblasts were used to study the in vitro attachment of cells to the root surface of periodontally-involved teeth. The portion of the root exposed to the disease process had little or no cell attachment; on the remainder of the root, the cells attached normally. Prior extraction of the roots with phenol-water or the mechanical removal of diseased cementum allowed the cells to attach normally. All things being equal, the extrapolation of these data to an in vivo situation dictates that a clinical success would depend upon complete removal of toxic materials from diseased cementum or the removal of the cementum itself.
267 citations
TL;DR: Somatostatin, a hypothalamic peptide, suppresses hydrochloric acid-stimulated release of secretin, pancreatic flow rate, and bicarbonate and protein secretion in fasted, conscious dogs.
Abstract: Somatostatin, a hypothalamic peptide, suppresses hydrochloric acid-stimulated release of secretin, pancreatic flow rate, and bicarbonate and protein secretion in fasted, conscious dogs. It also reduces nonstimulated pancreatic exocrine secretion but does not affect basal secretin concentrations. Suppression of HCl-stimulated secretin release is complete, whereas pancreatic flow rate and bicarbonate and protein secretions are only partially inhibited. The action of somatostatin is rapid in onset and quickly reversible.
252 citations
TL;DR: In this article, a vector definition of multivariate hazard rate and associated definitions of increasing and decreasing hazard rate distributions are presented, and the results of these definitions are worked out in a number of special cases.
238 citations
TL;DR: Although the rat K- NPPase appeared almost completely insensitive to ouabain with this cytochemical medium, parallel studies with the more glycoside-sensitive rabbit kidney indicated that K-NPPase activity in these nephron segments is sensitive to this inhibitor.
Abstract: A cytochemical method for the light and electron microscope localization of the K- and Mg-dependent phosphatase component of the Na-K-ATPase complex was applied to rat kidney cortex, utilizing p-nitrophenylphosphate (NPP) as substrate. Localization of K-N-ATPase activity in kidneys fixed by perfusion with 1% paraformaldehyde -0.25% glutaraldehyde demonstrated that distal tubules are the major cortical site for this sodium transport enzyme. Cortical collecting tubules were moderately reactive, whereas activity in proximal tubules was resolved only after short fixation times and long incubations. In all cases, K-NPPase activity was restricted to the cytoplasmic side of the basolateral plasma membranes, which are characterized in these neplron segments by elaborate folding of the cell surface. Although the rat K-NPPase appeared almost completely insensitive to ouabain with this cytochemical medium, parallel studies with the more glycoside-sensitive rabbit kidney indicated that K-NPPase activity in these nephron segments is sensitive to this inhibitor. In addition to K-NPPase, nonspecific alkaline phosphatase also hydrolyzed NPP. The latter could be differentiated cytochemically from the specific phosphatase, since alkaline phosphatase was K-independent, insensitive to ouabain, and specifically inhibited by cysteine. Unlike K-NPPPase, alkaline phosphatase was localized primarily to the extracellular side of the microvillar border of proximal tubules. A small amount of cysteine-sensitive activity was resolved along peritubular surfaces of proximal tubules. Distal tubules were unreactive. In comparative studies, Mg-ATPase activity was localized along the extracellular side of the luminal and basolateral surfaces of proximal and distal tubules and the basolateral membranes of collecting tubules.
197 citations
TL;DR: The NAPA/procainamide ratio in urine (collected 90 to 180 min after last dose) was found to be higher in rapid than in slow acetylators, indicating that NAP A probably contributes to the antiarrhythmic activity of procainamide therapy, especially in genetic rapid acetylator groups.
Abstract: N-Acetylprocainamide (NAPA) and procainamide plasma and urine concentrations were determined by thin-layer chromatography (TLC) densitometry in people of known acetylator phenotype (dapsone phenotyping) taking procainamide for more than 3 days. The plasma NAPA/procainamide ratio 3 hr after the last dose for fast acetylators (mean plus or minus SD) is 1.8 plus or minus 0.59 (N equal to 8) and for slow acetylators, 0.61 plus or minus 0.09 (N equal to 6) P smaller than 0.001). The renal clearance of NAPA averaged 1.2 times the simultaneously measured endogenous creatinine clearance, whereas procainamide clearance was approximately double the creatinine clearance. There was no difference between slow and rapid acetylators in the renal clearance of either drug or the urine pH, indicating that the difference in plasma NAPA/procainamide ratios between these two groups is due to differences in their rates of acetylation. Therefore, procainamide is probably acetylated by the polymorphic N-acetyltransferase in man. Reflecting the blood level differences, the NAPA/procainamide ratio in urine (collected 99 to 180 min after last dose) was found to be higher in rapid than in slow acetylators. The plasma protein binding of NAa and of procainamide are similar. Since NAPA seems to have an antiarrhythmic potency similar to procainamide, NAPA probably contributes to the antiarrhythmic activity of procainamide therapy, especially in genetic rapid acetylators.
188 citations
TL;DR: It is concluded that adrenaline, thrombin, 5HT, and vasopressin each can induce primary aggregation of human platelets by a mechanism independent of extracellular ADP.
173 citations
TL;DR: In this paper, a multivariate generalization of the farlie-Gumbel-Morgenstern bivariate system of distribution is described, and properties of orthant dependence are investigated.
Abstract: A multivariate generalization of the farlie-Gumbel-Morgenstern bivariate system of distribution is described. Certain properties, particularly those concerning orthant dependence, are investigated.
171 citations
TL;DR: Fifty-seven aneurysmal bone cysts which were associated with or secondary to other lesions of bone are reported, and the most common associations were with solitary or unicameral bone cyst, and with osteoclastoma.
Abstract: Fifty-seven aneurysmal bone cysts which were associated with or secondary to other lesions of bone are reported. The most common associations were with solitary or unicameral bone cyst, and with osteoclastoma. Other associated lesions included osteosarcoma, nonosteogenic fibroma, osteoblastoma, hemangioendothelioma, and hemangioma of bone. Five aneurysmal bone cysts were secondary to fracture or other bone trauma.
TL;DR: In this article, the coefficient vectors are treated as random drawings from a continuous multivariate distribution, and an approximate Bayesian solution is proposed to solve the problem of discontinuous shifts in regression regimes at unknown points in the data series.
Abstract: Quandt [20] analyzed the problem of discontinuous shifts in regression regimes at unknown points in the data series. We note that Quandt's statistical approach based solely on the likelihood function can be misleading, whereas the Bayesian method based on a proper prior distribution of the unknown parameters yields sensible results. However, the exact evaluation of the posterior distribution is unusually burdensome and cannot be simplified even in large samples. To avoid this difficulty, we suggest an alternative formulation and provide an approximate Bayesian solution. In this alternative formulation, the coefficient vectors are treated as random drawings from a continuous multivariate distribution.
TL;DR: Lipoteichoic acid from several Gram-positive microorganisms, Forssman antigen (Fag) from Diplococcus pneumoniae R36A, and an acidic lipopolysaccharide (ALP) from Micrococcus luteus were examined for effects on four wall lysis systems, and LTAs failed to inhibit the amidase of pneumococcus.
01 Jan 1975
TL;DR: A selective survey of developments in the area of continuous multivariate statistical distributions during the twentieth century is presented in this article with emphasis on non-normal models, and an extension of a useful bivariate family is indicated.
Abstract: A selective survey of developments in the area of continuous multivariate statistical distributions during the twentieth century is presented with emphasis on non-normal models. Discrete multivariate distributions are not discussed. An extension of a useful bivariate family is indicated.
TL;DR: It is concluded that yellow/blue equilibrium can be described as the zeroing of a nonlinear functional, which is, however, approximately linear in the short-wavelength and middle-wa wavelength cone responses and nonlinear only in the long-Wavelength (“red”) cone response.
TL;DR: Using a translational assay and new analytical procedures, it is found that histone mRNA can be detected both associated with polyribosomes and in the postribosomal supernatant of S phase HeLa S3 cells, and this observation is consistent with the idea of a transcriptional block in histone RNA production and transport to the cytoplasm during G1.
TL;DR: In this paper, the authors investigated the distribution of the vector (X 1,n−i1*, X 2,n-i2*, ···, Xm,n −im*) not depending on n.
Abstract: Let (X 1j , X 2j , ···, Xmj ), j = 1, 2, ···, n, be a sample of size n on an m-dimensional vector (X 1, X 2, ···, Xm ), m ≥ 2. Let the order statistics of the rth component be denoted by X r,1* ≤ X r,2* ≤ ··· ≤ X r,n *. In this article we investigate the distribution of the vector (X 1,n−i1*, X 2,n–i2*, ···, Xm,n–im *) for (i 1, i 2, ···, im ) not depending on n. The major emphasis is on asymptotic theory and a general formula is given for the asymptotic distribution of the vector above when each ij = 0. Necessary and sufficient condition is also given for the asymptotic independence of the components of the vector investigated. This extends results known for m = 2. In Section 4 examples are given for illustration.
TL;DR: The thymus is now known to play a major role in the ultimate activation of the lymphocyte, and a consideration of its role in normal function must precede the discussion of the various abnormal states.
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TL;DR: The stimulation of P-enolpyruvate carboxykinase synthesis is the major mechanism for the increase in the level of the enzyme observed in metabolic acidosis.
TL;DR: The effect of electrolytes and urea on the cloud points of the following three nonionic polyoxyethylated surfactants was studied: cetyl, stearyl, and oleyl alcohol adducts containing 10 ethylene oxide units and indicates the need for revising the theories of the effects of salts on the solubility of nonelectrolytes in water.
TL;DR: Format and instructional revisions were made in the TRF, a previously reported school adjustment measure, to extend its diagnostic, prescriptive, and empirical utility, and comparative comparisons provide evidence of the CARS discriminative validity and screening potential.
Abstract: Format and instructional revisions were made in the TRF, a previously reported school adjustment measure, to extend its diagnostic, prescriptive, and empirical utility. Factor analyses of school adjustment ratings on the revised CARS with a normative sample of "healthy" primary graders demonstrated that while the revisions maintained the scale's original three-factor structure, they increased specific item factor loadings and accounted scale variance. To extend the screening utility of the proposed measure, normative and parametric comparisons are reported describing adjustment ratings for sex, age, and city/country subgroups. Comparisons of children who are or are not referred to a secondary prevention program provide evidence of the CARS discriminative validity and screening potential.
TL;DR: The evidence presented above shows clearly that the application of certain principles of cell cycle kinetics can be of great benefit in the design of cancer treatments.
TL;DR: Tissue specimens studied from patients with male pattern alopecia revealed the presence of miniature or vellus follicles; a marked enlargement of the sebaceous glands and arrectores pilorum muscles; and the thinning of the dermis.
Abstract: Three hundred and forty-seven tissue specimens were studied from 23 patients with male pattern alopecia. Characteristic features of pattern alopecia included: the presence of miniature or vellus follicles; a marked enlargement of the sebaceous glands and arrectores pilorum muscles; the presence of connective tissue streamers beneath the vellus follicles; and the thinning of the dermis. A mild perivascular infiltrate of mononuclear cells and mild capillary dilatation was sometimes seen. An increased number of mast cells was often a prominent feature. Histochemical procedures were performed for glycogen, acid mucosaccharides, inorganic substances, and enzymes including alkaline phosphatase, acid phosphatase, beta glucuronidase, cholinesterase, aminopeptidase, oxidases and dehydrogenases. Histochemical studies did not reveal any significantly abnormal enzyme changes other than the altered vascular and nerve supply to the the miniature follicles.
TL;DR: Evidence of sperm chemotaxis to egg water and egg extracts of Ciona intestinalis, a primitive chordate, implies that spermChemotaxis either has evolved independently in groups widely separate on the phylogenetic scale or is widespread in the animal kingdom.
Abstract: CHEMOTAXIS of animal sperm, long thought not to occur1–4, was first proved in the marine coelenterate Campanularia5 and since then has been observed in other hydroids6,8. The species-specificities and cross reactions between sperm and reproductive structures of these species and genera have been described6, and some of the attractants have been isolated and their chemical properties reported7. In spite of circumstantial evidence for sperm chemotaxis in other phyla13,14 the sperm behaviour leading to aggregation has not been described. I now report evidence of sperm chemotaxis to egg water and egg extracts (see Table 1 for details) of Ciona intestinalis (Protochordata: Urochordata), a primitive chordate. These results imply that sperm chemotaxis either has evolved independently in groups widely separate on the phylogenetic scale or is widespread in the animal kingdom.
TL;DR: Minimal inhibitory concentrations for selected antibiotics were determined, under these conditions, by using a conventional twofold dilution scheme for the antibiotics and a “categorization three-tube method” in which two or three clinically significant concentrations of each antibiotic were used.
Abstract: A broth-dilution method for performing antimicrobial susceptibility tests on anaerobic bacteria has been proposed. The medium used in the test was Schaedler broth, with incubation in a glove box with an atmosphere of 5% CO(2), 10% H(2), and 85% N(2), or in the GasPak system. Minimal inhibitory concentrations for selected antibiotics were determined, under these conditions, by using a conventional twofold dilution scheme for the antibiotics and a "categorization three-tube method" in which two or three clinically significant concentrations of each antibiotic were used. Minimal inhibitory concentrations obtained by both methods were very similar. The categorization method could be used routinely to test the antimicrobial susceptibility of anaerobic bacteria.
TL;DR: It is suggested that hepatic phosphoenolpyruvate carboxykinase activity is regulated predominantly by the antagonistic interaction of cAMP (glucagon) and insulin on enzyme synthesis.
Abstract: Antiserum prepared against rat liver cytosolic phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) is shown to specifically precipitate the enzyme from Reuber H-35 cells. Synthesis of phosphoenolpyruvate carboxykinase, as measured immunochemically, is increased by dibutyryl cAMP and dexamethasone, the nucleotide maximally producing a sixfold and the glucocorticoid a threefold change in rate. Studies with actinomycin D, cordycepin, and cycloheximide suggest dibutyryl cAMP acts at a translational or post-transcriptional site. Insulin prevents the increase in synthesis of phosphoenolpyruvate carboxykinase produced by either dibutyryl cAMP or dexamethasone. This antagonism is concentration dependent and does not require the simultaneous presence of glucose, pointing to a direct effect of the hormone on liver enzyme induction. It is suggested that hepatic phosphoenolpyruvate carboxykinase activity is regulated predominantly by the antagonistic interaction of cAMP (glucagon) and insulin on enzyme synthesis.
TL;DR: Analysis of the clinical material revealed that the odontogenic myxoma occurred most frequently in the posterior regions of the mandible and will recur if initial therapy is too conservative and the tumors are probably responsible for the secretion of the myxomatous intercellular material of the neoplasm.
TL;DR: Since the physiological de-inducer of liver phosphoenolpyruvate carboxykinase (GTP) is insulin, this is the probable cause of the decrease in the synthesis rate of the hepatic enzyme noted when glucocorticoids are administered to non-diabetic animals.
Abstract: The effect glucocorticoids on the synthesis and degradation of phosphoenolpyruvate carboxykinase (GTP)(EC4.1.1.32) in rat liver and kidney in vivo was studied immunochemically. The glucocorticoid analogue triamcinolone (9alpha-fluoro-11beta, 21-dihydroxy-16alpha,17alpha-isopropylidenedioxypregna-1,4-diene-3,20-dione) increased the synthesis rate of the kidney enzyme in starved animals. Both triamcinolone and cortisol decreased the synthesis rate of hepatic phosphoenolpyruvate carboxykinase (GTP) in fed and starved rats, but were without effect on the degradation rate of the enzyme. This effect of triamcinolone in liver was reversed by injection of dibutyryl cyclic AMP. However, in diabetic animals glucocorticoids increased the synthesis rate of hepatic phosphoenolpyruvate carboxykinase (GTP). Triamcinolone administration to starved rats in vivo is shown to cause an increase in the portal blood concentrations of insulin and glucose. Since the physiological de-inducer of liver phosphoenolpyruvate carboxykinase (GTP) is insulin, this is the probable cause of the decrease in the synthesis rate of the hepatic enzyme noted when glucocorticoids are administered to non-diabetic animals.