Showing papers by "Temple University published in 2002"

Content Analysis in Mass Communication: Assessment and Reporting of Intercoder Reliability

Abstract: As a method specifically intended for the study of messages, content analysis is fundamental to mass communication research. Intercoder reliability, more specifically termed intercoder agreement, is a measure of the extent to which independent judges make the same coding decisions in evaluating the characteristics of messages, and is at the heart of this method. Yet there are few standard and accessible guidelines available regarding the appropriate procedures to use to assess and report intercoder reliability, or software tools to calculate it. As a result, it seems likely that there is little consistency in how this critical element of content analysis is assessed and reported in published mass communication studies. Following a review of relevant concepts, indices, and tools, a content analysis of 200 studies utilizing content analysis published in the communication literature between 1994 and 1998 is used to characterize practices in the field. The results demonstrate that mass communication researchers often fail to assess (or at least report) intercoder reliability and often rely on percent agreement, an overly liberal index. Based on the review and these results, concrete guidelines are offered regarding procedures for assessment and reporting of this important aspect of content analysis.

Beyond Survival: Achieving New Venture Growth by Building Legitimacy

Abstract: In this article we argue that (1) legitimacy is an important resource for gaining other resources, (2) such resources are crucial for new venture growth, and (3) legitimacy can be enhanced by the strategic actions of new ventures. We review the impact of legitimacy on new ventures as well as sources of legitimacy for new ventures, present strategies for new ventures to acquire legitimacy, explore the process of building legitimacy in the new venture, and examine the concept of the legitimacy threshold.

Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction.

Abstract: Plasma free fatty acids (FFA) play important physiological roles in skeletal muscle, heart, liver and pancreas. However, chronically elevated plasma FFA appear to have pathophysiological consequences. Elevated FFA concentrations are linked with the onset of peripheral and hepatic insulin resistance and, while the precise action in the liver remains unclear, a model to explain the role of raised FFA in the development of skeletal muscle insulin resistance has recently been put forward. Over 30 years ago, Randle proposed that FFA compete with glucose as the major energy substrate in cardiac muscle, leading to decreased glucose oxidation when FFA are elevated. Recent data indicate that high plasma FFA also have a significant role in contributing to insulin resistance. Elevated FFA and intracellular lipid appear to inhibit insulin signalling, leading to a reduction in insulin-stimulated muscle glucose transport that may be mediated by a decrease in GLUT-4 translocation. The resulting suppression of muscle glucose transport leads to reduced muscle glycogen synthesis and glycolysis. In the liver, elevated FFA may contribute to hyperglycaemia by antagonizing the effects of insulin on endogenous glucose production. FFA also affect insulin secretion, although the nature of this relationship remains a subject for debate. Finally, evidence is discussed that FFA represent a crucial link between insulin resistance and beta-cell dysfunction and, as such, a reduction in elevated plasma FFA should be an important therapeutic target in obesity and type 2 diabetes.

Invisible Inequality: Social Class and Childrearing in Black Families and White Families

Abstract: Although family life has an important impact on children’s life chances, the mechanisms through which parents transmit advantages are imperfectly understood. An ethnographic data set of white children and black children approximately 10 years old shows the effects of social class on interactions inside the home. Middle-class parents engage in concerted cultivation by attempting to foster children’s talents through organized leisure activities and extensive reasoning. Working-class and poor parents engage in the accomplishment of natural growth, providing the conditions under which children can grow but leaving leisure activities to children themselves. These parents also use directives rather than reasoning. Middle-class children, both white and black, gain an emerging sense of entitlement from their family life. Race had much less impact than social class. Also, differences in a cultural logic of childrearing gave parents and their children differential resources to draw on in their interactions with professionals and other adults outside the home. Middle-class children gained individually insignificant but cumulatively important advantages. Working-class and poor children did not display the same sense of entitlement or advantages. Some areas of family life appeared exempt from the effects of social class, however.

A Human Genome Diversity Cell Line Panel

Abstract: A resource of 1064 cultured lymphoblastoid cell lines (LCLs) ([1][1]) from individuals in different world populations and corresponding milligram quantities of DNA is deposited at the Foundation Jean Dausset (CEPH) ([2][2]) in Paris. LCLs were collected from various laboratories by the Human Genome

Clinical trials in head injury

Abstract: Traumatic brain injury (TBI) remains a major public health problem globally. In the United States the incidence of closed head injuries admitted to hospitals is conservatively estimated to be 200 per 100,000 population, and the incidence of penetrating head injury is estimated to be 12 per 100,000, the highest of any developed country in the world. This yields an approximate number of 500,000 new cases each year, a sizeable proportion of which demonstrate signficant long-term disabilities. Unfortunately, there is a paucity of proven therapies for this disease. For a variety of reasons, clinical trials for this condition have been difficult to design and perform. Despite promising pre-clinical data, most of the trials that have been performed in recent years have failed to demonstrate any significant improvement in outcomes. The reasons for these failures have not always been apparent and any insights gained were not always shared. It was therefore feared that we were running the risk of repeating our mistakes. Recognizing the importance of TBI, the National Institute of Neurological Disorders and Stroke (NINDS) sponsored a workshop that brought together experts from clinical, research, and pharmaceutical backgrounds. This workshop proved to be very informative and yielded many insights into previous and future TBI trials. This paper is an attempt to summarize the key points made at the workshop. It is hoped that these lessons will enhance the planning and design of future efforts in this important field of research.

Encouraging Citizen Adoption of E-Government by Building Trust

Abstract: The growing interest in e-Government raises the question of how governments can increase citizen adoption and usage of their online government services. e-Government becomes especially important given its potential to reduce costs and improve service compared with alternative traditional modes. Citizen trust is proposed to be an important catalyst of e-Government adoption. By investigating online tax services, already available and used extensively in the West, we propose several ways in which governments can increase citizen trust and thus encourage the adoption of this new and potentially significant mode of government service. The proposed e-Government adoption model also takes in account issues of cultural variables, risk, control and technology acceptance.Institution-based trust, such as an independent judicial system with appropriate legal powers, is proposed to be the major tactic to build trust in e-Government. In addition, among new users of online government services, characteristic-based and cognitive-based antecedents should be crucial; general psychological dispositions and knowledge of the process should also engender trust. Among experienced users, on the other hand, it is suggested that the nature of previous interactions with the e-Government system should be the major predictor of trust, and hence of continued use. These propositions are elucidated, as they apply to different cultures and to high-intrusive versus low-intrusive government services. This study has practical implications for the design of mechanisms for the adoption of e-Government.

Multinationality and firm performance: The moderating role of R&D and marketing capabilities

Abstract: Researchers in international business have long been interested in understanding the relationship between the multinationality of a firm and its market performance. This article contributes to this research stream by incorporating firm heterogeneity in examining the multinationality-performance relationship. The findings, based on a time series cross-sectional analysis of firms from 12 different industries over a seven-year period, indicate that the impact of multinationality on both financial and operational performance is moderated by firm's R&D and marketing capabilities.

Founding Family Ownership and the Agency Cost of Debt

Abstract: We investigate the impact of founding-family ownership structure on the agency cost of debt. We find that founding-family ownership is common in large, publicly traded firms and is related, both statistically and economically, to a lower cost of debt financing. The evidence also indicates that the relation between founding-family holdings and debt costs is non-monotonic; debt costs first decrease as family ownership increases but then increase with increasing family ownership. However, irrespective of the level of family holdings, we find that family firms enjoy a lower cost of debt than non-family firms. These results are consistent with the hypothesis that continued founding-family ownership in publicly traded firms reduces the agency costs of debt. Additional analysis reveals that when a family member serves as the firm's CEO, the cost of debt financing is higher than if an outsider is CEO, but still lower than in non-family firms. Overall, the results are consistent with the idea that founding-family firms have incentive structures that result in fewer agency conflicts between equity and debt claimants, suggesting that bond investors view founding-family ownership as an organizational structure that better protects their interests.

LANGUAGE SOCIALIZATION: Reproduction and Continuity, Transformation and Change

Abstract: ▪ Abstract While continuing to uphold the major aims set out in the first generation of language socialization studies, recent research examines the particularities of language socialization processes as they unfold in institutional contexts and in a wide variety of linguistically and culturally heterogeneous settings characterized by bilingualism, multilingualism, code-switching, language shift, syncretism, and other phenomena associated with contact between languages and cultures. Meanwhile new areas of analytic focus such as morality, narrative, and ideologies of language have proven highly productive. In the two decades since its earliest formulation, the language socialization paradigm has proven coherent and flexible enough not merely to endure, but to adapt, to rise to these new theoretical and methodological challenges, and to grow. The sources and directions of that growth are the focus of this review.

Hospital Admissions Resulting from Preventable Adverse Drug Reactions

Abstract: BACKGROUND:Adverse drug reactions (ADRs) are a significant cause of hospital admissions. These events can lead to significant morbidity and mortality and financial costs. ADRs that may be preventable might be considered a form of medication error.OBJECTIVE:To assess the potential preventability of ADRs directly related to a patient's hospital admission.METHODS:A retrospective chart review of 437 ADRs occurring during an 11-month period was conducted at a university hospital. A subset of these events leading to hospital admissions was identified for further review. Those that resulted in admission were further examined to determine probability of causality, severity, and preventability.RESULTS:Over 11 months, 158 ADRs were directly related to hospital admission. The relationship of these admissions to drug exposure was determined to be probable or highly probable in 154 (97.4%) of these cases. From this group, 96 (62.3%) of these events were considered potentially preventable, with 23 (24%) considered seve...

Distinct and Overlapping Features of Rumination and Worry: The Relationship of Cognitive Production to Negative Affective States

Abstract: Worry and rumination are cognitive processes, often represented as verbal or linguistic activities. Despite similarities in definition and description, worry has been most closely examined in relation to anxiety whereas rumination has traditionally been related to depression. This distinction remains in spite of high rates of comorbidity between anxiety and depression. This study sought to better understand the distinct and overlapping features of worry and rumination as well as their relationship to anxiety and depression. Seven hundred eighty-four unselected college students completed self-report measures of worry, rumination, anxiety, and depression. Items from the respective worry and rumination scales were submitted to factor analysis, which revealed a four-factor solution comprised of 2 worry factors and 2 rumination factors. A Worry Engagement factor as well as a Dwelling on the Negative factor emerged as distilled measures of worry and rumination, respectively. Scores on these factors were highly correlated with each other and demonstrated equally strong relationships to both anxiety and depression. Findings from this study suggest that worry and rumination represent related but distinct cognitive processes that are similarly related to anxiety and depression.

Branding Importance in Business-to-Business Markets: Three Buyer Clusters

Abstract: With the growth of e-commerce and global competition, business-to-business (B2B) marketers are showing increased interest in the potential of branding, especially at the corporate level. This paper describes branding in the context of B2B markets, and examines its perceived importance to buyers. A review of relevant literature and the development of a conceptual model enables a cluster analysis of data from a survey of industrial buyers. The exploratory analysis examines to whom branding is important, and in what situations. Three clusters of buyers are found: branding receptive, highly tangible, and low interest. The practical implications for managers are explored.

Applying an Emotion Regulation Framework to Integrative Approaches to Generalized Anxiety Disorder

Abstract: Integrative conceptualizations like that proposed byRoemer and Orsillo provide exciting new directions forunderstanding and treating generalized anxiety disorder(GAD). However, these approaches may be furtherstrengthened by adoption of an emotion regulationperspective. Persons with GAD may have difficulty un-derstanding their emotional experience and may pos-sess few skills to modulate their emotions. They mayexperience emotions as subjectively aversive and useworry and maladaptive interpersonal behaviors as de-fensive strategies to control, avoid, or blunt emotionalexperience. An emotion regulation perspective suggestsadding treatment components to help clients becomemore comfortable with arousing emotional experience,more able to access and utilize emotional informationin adaptive problem solving, and better able to modu-late emotional experience and expression according tocontextual demands.Key words: emotion regulation, generalized anxietydisorder. [Clin Psychol Sci Prac 9:85–90, 2002]

Temperamental Vulnerability and Negative Parenting as Interacting Predictors of Child Adjustment

Abstract: This study examines parenting by temperament interactions in predicting child adjustment. Participants included 40 first and second graders, their mothers, and teachers. Child report of maternal psychological control and hostility was assessed using the Child Puppet Interview. Mothers completed temperament scales from the Child Behavior Questionnaire, and teachers provided information on child adjustment. As expected, among children high in irritable distress, maternal psychological control was associated with internalizing problems and maternal hostility was associated with externalizing problems. Among children with poor effortful control, maternal hostility was associated with externalizing behavior. This study offers evidence that the effects of negative parenting are accentuated among children with temperamental vulnerabilities.

Identification and functions of usefully disordered proteins.

Abstract: Publisher Summary This chapter illustrates that protein disorder is encoded by the amino acid sequence and that protein disorder is essential for many important biological functions. An ordered protein contains a single canonical set of Ramachandran angles, whereas a disordered protein or region contains an ensemble of divergent angles at any instant and these angles interconvert over time. Intrinsically disordered protein can be extended (random coil–like) or collapsed (molten globule–like). The latter type of disorder typically includes regions of fluctuating secondary structure, so disorder does not mean absence of helix or sheet. Both types of disorders have been observed in apparently native proteins. Intrinsic disorder might not be encoded by the sequence, but rather might be the result of the absence of suitable tertiary interactions. If this were the general cause of intrinsic disorder, any subset of ordered sequences and any subset of disordered sequences would likely be the same within the statistical uncertainty of the sampling. On the other hand, if intrinsic disorders were encoded by the amino acid sequence, any subset of disordered sequences would likely differ significantly from samples of ordered protein sequences.

Toward a sociocognitive approach to second Llanguage acquisition

Abstract: This article develops the notion of a sociocognitive perspective on second language acquisition (SLA), proposed as an alternative to the cognitivism pervading the field. By sociocognitive, I mean a view of language and language acquisition as simultaneously occurring and interactively constructed both “in the head” and “in the world.” First, I develop a view of language and its acquisition as social phenomena—as existing and taking place for the performance of action in the (socially-mediated) world. Second, I describe the cognitive nature of language and its acquisition, focusing especially on recent developments in connectionism. Third, I introduce sociocognitive views of language and posit a social interpretation of connectionism as bridging the gap between cognition and social action. Fourth, I discuss sociocognitive perspectives on first language acquisition. Fifth, I describe the cognitivist biases of much SLA research, then suggest how sociocognitive approaches can help overcome them. I end by considering implications of the perspective I develop in this paper.

Cognitive-Behavioral Group Therapy for Social Phobia: Basic Mechanisms and Clinical Strategies

Abstract: Part I: Understanding the Nature of Social Phobia. The Diagnosis and Etiology of Social Phobia. Subtypes of Social Phobia, Comorbidity, and Impairment. Cognitive Function in Social Phobia. Dysfunctional Cognitive Processes in Social Phobia. A Cognitive-Behavioral Formulation of Social Phobia (with Ronald M. Rapee and Cynthia L. Turk). Assessment of Social Phobia (with Cynthia L. Turk). Part II: Cognitive-Behavioral Group Therapy for Social Phobia: A Treatment Manual. An Overview of Cognitive-Behavioral Group Therapy for Social Phobia. The Treatment Orientation Interview. Session 1. Session 2. In-Session Exposures. Integrating Cognitive Restructuring Procedures with In-Session Exposures. Homework Procedures. Sessions 3-12: Putting It All Together and Troubleshooting Cognitive-Behavioral Therapy.

Bioavailability of DON from natural and anthropogenic sources to estuarine plankton

Abstract: Utilization of dissolved organic nitrogen (DON) from natural (forests) and anthropogenic (animal pastures, urban/ suburban storm water runoff) sources (three sites per source) by estuarine plankton communities was examined in spring, summer, and fall. The proportion of DON utilized ranged from 0 to 73%. Overall, urban/suburban storm water runoff had a higher proportion of bioavailable DON (59% 6 11) compared to agricultural pastures (30% 6 14) and forests (23% 6 19). DON bioavailability varied seasonally; however, the seasonal pattern differed for the three sources. Bacterial production increased linearly with the amount of DON utilized across all sources and seasons; the rate of increase was approximately five times greater per micromole of N as DON used relative to dissolved inorganic N (DIN) used. Although phytoplankton production generally increased with DON addition, the increased production was not correlated with the amount of DON utilized, suggesting that a variable portion of dissolved organic matter (DOM)-N was directly or indirectly available to the phytoplankton. This indicates that phytoplankton production is not a good measure of the amount of bioavailable DON, and measurements of the amount of bioavailable DON based on bacterial responses alone might not reflect N available to phytoplankton. Preliminary seasonal budgets of bioavailable N (DIN plus bioavailable DON) as a function of land use suggest that ;80% of the total dissolved N (TDN) from urban/suburban runoff is bioavailable, whereas a lower proportion (20‐ 60%) of TDN is bioavailable from forests and pastures. N budgets for aquatic ecosystems based on only DIN loading underestimate bioavailable N loading, whereas total N or TDN budgets overestimate bioavailable N inputs.

GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress.

Abstract: Gadd45a (Gadd45), Gadd45b (MyD118), and Gadd45g (CR6) constitute a family of evolutionarily conserved, small, acidic, nuclear proteins, which have been implicated in terminal differentiation, growth suppression, and apoptosis. How Gadd45 proteins function in negative growth control is not fully understood. Recent evidence has implicated Gadd45a in inhibition of cdc2/cyclinB1 kinase and in G2/M cell cycle arrest. Yet, whether Gadd45b and/or Gadd45g function as inhibitors of cdc2/cyclinB1 kinase and/or play a role in G2/M cell cycle arrest has not been fully established. In this work, we show that Gadd45b and Gadd45g specifically interact with the Cdk1/CyclinB1 complex, but not with other Cdk/Cyclin complexes, in vitro and in vivo. Data also has been obtained that Gadd45b and Gadd45g, as well as GADD45a, interact with both Cdk1 and cyclinB1, resulting in inhibition of the kinase activity of the Cdk1/cyclinB1 complex. Inhibition of Cdk1/cyclinB1 kinase activity by Gadd45b and Gadd45a was found to involve disruption of the complex, whereas Gadd45g did not disrupt the complex. Moreover, using RKO lung carcinoma cell lines, which express antisense Gadd45 RNA, data has been obtained, which indicates that all three Gadd45 proteins are likely to cooperate in activation of S and G2/M checkpoints following exposure of cells to UV irradiation.